Adenocarcinoma Metastasis from Colon to the Thyroid

Mardani, Parviz; Ayareh, Nazanin; Kamran, Hooman; Shahriarirad, Reza; Vafabin, Masoud; Soleimani, Neda

doi:10.1155/2022/8705143

Cited by 1 publication

(1 citation statement)

References 14 publications

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“…PTC TT & LND Lung Mori et al, 2020 [ 14 ] 45, F Rectum Low Anterior Resection 5 CT, PET, US, FNA -Non-Diag R PT & LND Lung Rojo-Abecia et al, 2020 [ 15 ] 85, F Caecum R hemicolectomy 14 PET, FNA R PT Lung Hernandez et al, 2020 [ 5 ] 50, F Rectum Neo-adjuvant chemo-radiotherapy, anterior resection & total mesorectal excision 3.5 US, CT, FNA -? PTC TT & LND Lung Momin et al, 2022 [ 16 ] 62, F Caecum R hemicolectomy 6 US, FNA, MRI neck, PET R PT Lung Liver Mardani et al, 2022 [ 17 ] 55, F Descending colon L hemicolectomy, adjuvant chemo-radiotherapy 8 PET, FNA -? PTC TT & LND Lung Abbreviations : Time The number of years to develop thyroid metastases after initial diagnosis of colorectal cancer, y Years, Studies Investigations and diagnostic studies done to evaluate thyroid metastases, Met Metastases, TX Treatment/management; US Ultrasonography, FNA Fine needle aspiration, PET Positron emission tomography, PTC Papillary thyroid carcinoma, CT Computed tomography, MRI Magnetic resonance imaging, ST Subtotal thyroidectomy, TT Total thyroidectomy, L Left, R Right, PT Partial thyroidectomy, & And, LND Lymph node dissection, Non-Diag Non-diagnostic,?…”

Section: Introductionmentioning

confidence: 99%

Colorectal cancer metastases in thyroid: case report and literature review

2023

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Background The thyroid gland is an uncommon site for metastatic deposits from non-thyroid malignancies, occurring in only 1.4 - 3% of surgical specimens where malignancy is suspected. It is even rarer for the source of thyroid metastases to be of colorectal origin. In most cases reported, colorectal metastases in the thyroid occurs many years later after the primary colorectal cancer has been diagnosed and treated. In this unique case, a primary sigmoid carcinoma metastasised to the thyroid gland and presented synchronously as a thyroid nodule. Case presentation We describe a case of a 64-year-old Caucasian woman who presented with clinical features of metastatic cancer of unknown origin. Her medical history included underlying hyperthyroidism. She had a large pelvic mass adjacent to the sigmoid colon, a left lower lobe lung mass and a suspicious nodule in the left thyroid lobe. A fine-needle aspiration biopsy of the thyroid nodule was performed, which remarkably showed malignant cells originating from primary colorectal cancer on immunohistochemical staining. The patient was managed with palliative chemotherapy given the poor prognosis due to disseminated colorectal malignancy. Conclusions Colorectal adenocarcinoma metastases can rarely present as a metastatic thyroid nodule. Fine-needle aspiration should be performed in suspicious thyroid nodules and may be the least invasive way of identifying a metastatic colorectal or other non-thyroidal malignancy in patients presenting with an unknown primary. The pathologist should be vigilant to this possibility and specific immunohistochemical markers should be used to ensure accurate diagnosis. In thyroid metastases, the prognosis is ultimately determined by the primary tumour but thyroidectomy still has a role in alleviating compressive symptoms and can potentially improve survival in selected cases.

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