Adenocarcinoma in the transposed colon: High grade active inflammation versus low grade chronic inflammation

Sterpetti, Antonio V.; Sapienza, Paolo

doi:10.1016/j.ejso.2019.05.012

Cited by 14 publications

(6 citation statements)

References 56 publications

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“…The etiology of neovaginal adenocarcinoma is unknown and is likely associated with inflammation, human papillomavirus (HPV) infection, the tissue microenvironment, and lifestyle factors. Sterpetti et al ( 18 ) found that age, as well as the clinical and histological characteristics, of patients with neovaginal cancer is similar to that of patients diagnosed with sporadic colorectal cancer in the general population; moreover, the prevalence rates of both are similar. Bacterial overgrowth, infection, and inflammation may be risk factors leading to chronic or acute inflammation and damage to the colonic mucosa, which can eventually lead to carcinoma.…”

Section: Discussionmentioning

confidence: 95%

Cervical and endometrial cancers of intestinal origin diagnosed 18 years after vaginal replacement with a sigmoid colon segment: a case report and review of the literature

Sun

Miao

et al. 2022

Front. Oncol.

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BackgroundSigmoid colpoplasty is a surgical method for the treatment of vagina agenesis. Malignant tumors of neovaginas derived from sigmoid colons are rare.Case presentationWe report a 33-year-old woman who underwent sigmoid colpoplasty for vaginal agenesis and presented 18 years later with vaginal bleeding. Examination revealed cancer of the neovagina with involvement of the cervix and endometrium. The patient was administered four cycles of chemotherapy because she refused surgery.ConclusionsPatients with a history of colpoplasty should undergo long-term comprehensive testing after reconstruction, including regular gynecological, colposcopic, and gastrointestinal examinations. In patients with cancer of the neovagina, a comprehensive treatment plan should be developed in consultation with gynecologists and surgeons. There is no standard treatment, although surgery plus chemotherapy or radiotherapy appears to be effective.

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Section: Discussionmentioning

confidence: 95%

Cervical and endometrial cancers of intestinal origin diagnosed 18 years after vaginal replacement with a sigmoid colon segment: a case report and review of the literature

Sun

Miao

et al. 2022

Front. Oncol.

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“…However, the hypothesis that a major trauma related to standard pancreatic resections, including splenectomy, removal of uninvolved peripancreatic lymphatics, reduced endocrine and exocrine function, may determine a derangement of the immunological response in a clinical scenario of a delicate balance between the host reaction and a slow growing tumor is possible [61][62][63]. At the same time, it is conceivable that if the above hypothesis is correct, then there are no viable tumor cell nests outside the pancreas and the additional resection of surrounding structures in standard resections will not lead to better results than enucleations, provided R0 resection is achieved.…”

Section: Discussionmentioning

confidence: 99%

Systematic Review and Meta-Analysis of Clinical Outcomes after Enucleation of Pancreatic Metastases from Renal Cell Carcinoma

Brozzetti

Carati

Sterpetti³

2023

Dig Surg

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ABSTRACT. Introduction: A systematic review of the literature was carried out to determine the clinical and oncological outcome of patients who had enucleation of solitary pancreatic metastases from renal cell carcinoma. Methods: Operative mortality, postoperative complications, observed survival and disease free survival were analyzed. The clinical outcomes of patients who had enucleation were compared to those of 857 patients collected from the literature who had standard or atypical pancreatic resection for the same disease using propensity score matching Results: There was no postoperative mortality in the 56 patients who had enucleation of pancreatic metastases from renal cell carcinoma . In 51 patients postoperative complications could be analyzed. Ten patients (10/51=19.6%) had postoperative complications. Three patients (3/51 = 5.9%) had major complications (Clavien-Dindo III or more). Five year observed survival rates and disease free survival for patients with enucleation were 92% and 79% respectively. These results compared favourably with those obtained in patients who had standard resection and other forms of atypical resection (also using propensity score matching). Patients who had partial pancreatic resection (atypical or not) with pancreatic-jejunal anastomosis had increased rates of postoperative complications and local recurrences. Conclusions: Enucleation of pancreatic metastases offers a valid solution in selected patients.

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“…The colonic wall was exposed to different bacterial flora. Conceptually the risk factors identified for sporadic colon cancer in the general population and in the surgically transposed colon have in common the possibility to promote inflammation either locally or systematically [4,5,10,11].…”

Section: Discussionmentioning

confidence: 99%

Risk factors for adenocarcinoma in the surgically transposed colon not exposed to the fecal stream. Etiological considerations extrapolated to sporadic colon carcinoma in the general population

Sterpetti

Marzo

Sapienza

2021

European Journal of Surgical Oncology

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Background: The aim of the study was to analyze the clinical characteristics and outcomes of patients with de novo secondary adenocarcinoma arising in the operatively transposed colon not exposed to the fecal stream. Methods: Two investigators collected and reviewed papers from June 1938 to June 2019, reporting patients with adenocarcinoma arising in the transposed colon, not in contact with the fecal stream. Results: Overall, we identified 98 patients with a transposed colonic autograft, positioned as conduit but not in contact with the fecal stream, in whom a secondary de novo adenocarcinoma was diagnosed. In 50% of the patients, the secondary adenocarcinoma was diagnosed at an advanced stage, with a subsequent poor clinical outcome. Earlier diagnosis allowed local resection with long term success. The occurrence of the adenocarcinoma appeared to be closely related to aging, and to clinical evidence of chronic inflammation. Conclusions: Patients in whom the colon has been surgically transposed to different anatomic positions, away from the fecal stream, can develop a secondary colonic adenocarcinoma with. Aging and chronic inflammation seem to be risk factors for a secondary adenocarcinoma more than time from implant. Screening for polyps and adenocarcinomas in these patients should be considered.

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Adenocarcinoma in the transposed colon: High grade active inflammation versus low grade chronic inflammation

Cited by 14 publications

References 56 publications

Cervical and endometrial cancers of intestinal origin diagnosed 18 years after vaginal replacement with a sigmoid colon segment: a case report and review of the literature

Cervical and endometrial cancers of intestinal origin diagnosed 18 years after vaginal replacement with a sigmoid colon segment: a case report and review of the literature

Systematic Review and Meta-Analysis of Clinical Outcomes after Enucleation of Pancreatic Metastases from Renal Cell Carcinoma

Risk factors for adenocarcinoma in the surgically transposed colon not exposed to the fecal stream. Etiological considerations extrapolated to sporadic colon carcinoma in the general population

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