Adenocarcinoma in situ of the uterine cervix

Muntz, Howard G.; Lage, Janice M.; Goff, Barbara A.; Feldman, Sheldon; Bell, Drew T.; Rice, Laurel W.

doi:10.1016/0090-8258(92)90551-s

Cited by 23 publications

(35 citation statements)

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“…Eighteen of these were reviewed, and the negative diagnosis was confirmed in all of them, thereby implicating sampling errors in at least some cases. 43 In the largest series describing …”

Section: Discussionmentioning

confidence: 99%

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Lee¹,

Minter²,

Granter³

1997

Am J Clin Pathol

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The sensitivity of cervical smears for adenocarcinoma in situ (AIS) is not known, nor is it known whether false-negative smears are due to sampling or to screening or interpretive errors. In 16 of 34 patients with AIS, 38 negative smears were reported 2 weeks to 7 years before biopsy. Thirty-one of these negative smears were rescreened, and 17 (55%) were retrospectively diagnosed as abnormal. The purpose of this study was to obtain an estimate of Pap smear sensitivity for AIS and to uncover difficulties in interpretation of smears that may have led to false-negative diagnoses. MATERIALS AND METHODS The surgical p a t h o l o g y files of Brigham andWomen's Hospital, Boston, were searched for case reports of AIS or AIS combined with squamous cervical intraepithelial neoplasia (CIN) with a complete cone biopsy, hysterectomy, or both for the years 1986 to 1995. All available smears diagnosed as negative before an initial biopsy confirming AIS were confirmed sampling errors. The sensitivity of cervical smears for AIS was 55% to 72%. Improved sampling of the endocervical canal offers cytologists the opportunity to diagnose AIS. This study demonstrates that this opportunity may not be fully exploited. Small "endometrioid" AIS cells and AIS cells resembling reactive endocervical cells may be mistaken for benign cells, thus decreasing sensitivity.

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“…Eighteen of these were reviewed, and the negative diagnosis was confirmed in all of them, thereby implicating sampling errors in at least some cases. 43 In the largest series describing …”

Section: Discussionmentioning

confidence: 99%

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Lee¹,

Minter²,

Granter³

1997

Am J Clin Pathol

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“…The conizations demonstrated AIS alone in nine cases with negative margins were carefully followed with frequent [19] 22 11 involved 5/11 11 not involved 2/11 Muntz et al [20] 22 10 involved 7/10 12 not involved 1/12 Present study 15 6 involved 4/6 9 not involved 4/9…”

Section: Introductionmentioning

confidence: 99%

Adequacy of Conization Margins in Adenocarcinomain Situof the Cervix as a Predictor of Residual Disease

Duska

Rosenshein

1995

Gynecologic Oncology

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“…According to the 2001 Consensus Guidelines for the Management of Women with Cervical Cytological Abnormalities, 24 nearly half the patients with biopsy-confirmed AIS have a coexisting squamous abnormality and, therefore, the presence of a coexisting squamous abnormality does not change the management of women with AGC or AIS. 21,[24][25][26] AGC is a significant indicator of more serious lesions, such as high-grade preinvasive squamous disease, AIS, and invasive adenocarcinoma. [1][2][3][8][9][10][11][12][13][14][15][16] This case illustrates that AGC found upon Pap smear during a pregnancy can be associated with significant pathology for which an aggressive management approach is warranted.…”

Section: Discussionmentioning

confidence: 99%

Atypical Papanicolaou Smear in Pregnancy

Connolly¹,

Evans²

2005

Clinical Medicine & Research

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Papani colaou (Pap) smears that contain atypical squamous cells of undetermined significance can be followed up with repeat smears. However, those that contain atypical glandular cells (AGC) are more likely to be associated with severe underlying conditions and, therefore, warrant particular attention. 1 The diagnosis of AGC by pathologists is difficult as there is a high degree of interobserver variation. [2][3][4][5][6][7] Up to 50% of women with AGC have significant histologic abnormalities, and cancer is present in 19.5% of women with AGC.

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Adenocarcinoma in situ of the uterine cervix

Cited by 23 publications

References 0 publications

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Papanicolaou Smear Sensitivity for Adenocarcinoma In Situ of the Cervix:A Study of 34 Cases

Adequacy of Conization Margins in Adenocarcinomain Situof the Cervix as a Predictor of Residual Disease

Atypical Papanicolaou Smear in Pregnancy

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