Adenine Nucleotides of Myocardium from Rats Treated with Isoproterenol and/or Mg- or K-Deficiency

Hattori, Eizou; Yatsuki, Kuniko; Miyazaki, Tadashi; Sata, Teizo; Nakamura, Motoomi

doi:10.1536/ihj.10.218

Cited by 7 publications

(1 citation statement)

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“…Guideri et al also reported that magnesium deficiency enhanced the incidence of ventricular fibrillation induced by isoproterenol along with the development of ventricular fibrillation preceded by serum and myocardial electrolyte alternations [23]. In our previous study [24], isoproterenol produced not only an increase in the heart rate but also a prolonged marked reduction of blood pressure, thus resulting in myocardial ischemia. Fiset et al recently reported that sudden unexpected death occurred in hypomagnesemic weanling rats after they were accidentally startled, and seizures consistently preceded death [25].…”

Section: Causes Of Sudden Deathmentioning

confidence: 60%

Magnesium deficiency in adult rats promotes the induction of ventricular tachycardia by the administration of epinephrine

1998

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The effects of magnesium deficiency on epinephrine-induced ventricular tachyarrhythmia were investigated in adult rats. Forty-two adult Wistar rats were fed a magnesium-deficient diet while 30 rats were fed a standard diet for 20 days. The plasma magnesium concentration was lower in the magnesium-deficient rats (0.22+/-0.01 mmol/l) than in the control rats (0.76+/-0.03 mmol/l, P < 0.001). Using a telemetry system, electrocardiograms and arterial blood pressure were recorded on a polygraph in an unrestrained condition. Epinephrine was infused intravenously starting at 5 microg/kg per minute. The QT interval was prolonged to 50+/-1 ms in the magnesium-deficient rats compared with 44+/-1 ms in the control rats (P < 0.001). Before the administration of epinephrine, no ventricular tachyarrhythmias or seizures were found in either the control or the magnesium-deficient rats. The incidence of epinephrine-induced sustained ventricular tachycardia (VT) was higher in the magnesium-deficient rats (86%) than in the control rats (43%, P < 0.01). However, this VT did not result in sudden death. Seizures always preceded death in both the magnesium-deficient and control rats while the arrhythmias observed immediately before death were mainly bradyarrhythmias. The present study in an adult rat magnesium-deficient model revealed that magnesium deficiency enhances the susceptibility to epinephrine-induced ventricular tachyarrhythmias.

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Section: Causes Of Sudden Deathmentioning

confidence: 60%