Adenine Nucleotide Translocase regulates the airway epithelium, mitochondrial metabolism and ciliary function

Kliment, Corrine R.; Nguyen, Jennifer M. K.; Kaltreider, Mary Jane; Lu, Ya‐Wen; Claypool, Steven M.; Radder, Josiah E.; Sciurba, Frank C.; Zhang, Yingze; Gregory, Alyssa D.; Iglesias, Pablo A.; Sidhaye, Venkataramana K.; Robinson, Douglas N.

doi:10.1101/2020.05.18.101378

Cited by 2 publications

(1 citation statement)

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“…At this point, we would like to briefly describe one of the latest studies performed by Kliment et al [ 114 ], just to underline how research on ANT is still fervent 30 years after its discovery and also to introduce the ANT2 isoform, which is involved in the development of chronic obstructive pulmonary disease (COPD). The authors observed that ANT2 expression is reduced in lung tissue from patients affected by COPD, and in a mouse smoking model.…”

Section: Ant: In Health and In Diseasementioning

confidence: 99%

A Walk in the Memory, from the First Functional Approach up to Its Regulatory Role of Mitochondrial Bioenergetic Flow in Health and Disease: Focus on the Adenine Nucleotide Translocator

Atlante

Valenti

2021

IJMS

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The mitochondrial adenine nucleotide translocator (ANT) plays the fundamental role of gatekeeper of cellular energy flow, carrying out the reversible exchange of ADP for ATP across the inner mitochondrial membrane. ADP enters the mitochondria where, through the oxidative phosphorylation process, it is the substrate of Fo-F1 ATP synthase, producing ATP that is dispatched from the mitochondrion to the cytoplasm of the host cell, where it can be used as energy currency for the metabolic needs of the cell that require energy. Long ago, we performed a method that allowed us to monitor the activity of ANT by continuously detecting the ATP gradually produced inside the mitochondria and exported in the extramitochondrial phase in exchange with externally added ADP, under conditions quite close to a physiological state, i.e., when oxidative phosphorylation takes place. More than 30 years after the development of the method, here we aim to put the spotlight on it and to emphasize its versatile applicability in the most varied pathophysiological conditions, reviewing all the studies, in which we were able to observe what really happened in the cell thanks to the use of the “ATP detecting system” allowing the functional activity of the ANT-mediated ADP/ATP exchange to be measured.

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Section: Ant: In Health and In Diseasementioning

confidence: 99%

A Walk in the Memory, from the First Functional Approach up to Its Regulatory Role of Mitochondrial Bioenergetic Flow in Health and Disease: Focus on the Adenine Nucleotide Translocator

Atlante

Valenti

2021

IJMS

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Why new biology must be uncovered to advance therapeutic strategies for chronic obstructive pulmonary disease

Nguyen

Robinson

Sidhaye³

2021

American Journal of Physiology-Lung Cellular and Molecular Phys

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Chronic obstructive pulmonary disease (COPD) is characterized by the destruction of alveolar tissue (in emphysema) and airway remodeling (leading to chronic bronchitis) which cause difficulties in breathing. It is a growing public health concern with few therapeutic options that can reverse disease progression or mortality. This is in part because current treatments mainly focus on ameliorating symptoms induced by inflammatory pathways as opposed to curing disease. Hence, emerging research focused on upstream pathways are likely to be beneficial in the development of efficient therapeutics to address the root causes of disease. Some of these pathways include mitochondrial function, cytoskeletal structure and maintenance, and airway hydration, which are all affected by toxins that contribute to COPD. Because of the complexity of COPD and unknown targets for disease onset, simpler model organisms have proven to be useful tools in identifying disease-relevant pathways and targets. This review summarizes COPD pathology, current treatments, and therapeutic discovery research, with a focus on the aforementioned pathways that can advance the therapeutic landscape of COPD.

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Adenine Nucleotide Translocase regulates the airway epithelium, mitochondrial metabolism and ciliary function

Cited by 2 publications

References 50 publications

A Walk in the Memory, from the First Functional Approach up to Its Regulatory Role of Mitochondrial Bioenergetic Flow in Health and Disease: Focus on the Adenine Nucleotide Translocator

A Walk in the Memory, from the First Functional Approach up to Its Regulatory Role of Mitochondrial Bioenergetic Flow in Health and Disease: Focus on the Adenine Nucleotide Translocator

Why new biology must be uncovered to advance therapeutic strategies for chronic obstructive pulmonary disease

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