Adecuación de la utilización de benzodiazepinas en ancianos desde la oficina de farmacia. Un estudio de colaboración médico-farmacéutico

Vila, Josefina Velert; Vila, Marcelo; Ibáñez, Luis Salar; Zaragoza, Juan Antonio Avellana; Royo, Lucrecia Moreno

doi:10.1016/j.aprim.2011.07.018

Cited by 18 publications

(23 citation statements)

References 25 publications

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“…Of the 47 records resulting from the search strategies, 24 (51.1%) full-text articles were retrieved for review concerning ADR 11 - 18 , 20 , 24 - 25 , 28 - 29 , 34 - 36 , 38 - 40 , 46 , 51 - 52 , 54 , 56 ) , 14 (29.8%) DDI 21 - 23 , 27 , 30 - 33 , 41 , 43 - 45 , 49 , 53 and nine (19.1%) are related to both DDI and ADR 19 , 26 , 37 , 42 , 47 - 48 , 50 , 55 , 57 , according to Figures 2 and 3.…”

Section: Resultsmentioning

confidence: 99%

“…In thirty-one studies there was no definition of polypharmacy 13 - 14 , 16 - 18 , 21 - 25 , 28 , 30 , 32 , 34 - 36 , 38 - 41 , 43 , 45 , 47 - 50 , 53 - 57 . Therefore, there is a need for a clear cut-off point that defines polypharmacy worldwide.…”

Section: Discussionmentioning

confidence: 99%

“…Initially, different definitions of polypharmacy were utilized in the studies analyzed such as ≥3 33 , ≥5 19 - 20 , 26 - 27 , 29 , 31 , 37 , 42 , 44 , 46 , 51 , ≥6 52 or ≥10 11 - 12 , 15 . In thirty-one studies there was no definition of polypharmacy 13 - 14 , 16 - 18 , 21 - 25 , 28 , 30 , 32 , 34 - 36 , 38 - 41 , 43 , 45 , 47 - 50 , 53 - 57 . Therefore, there is a need for a clear cut-off point that defines polypharmacy worldwide.…”

Section: Discussionmentioning

confidence: 99%

“…DDI and ADR are frequently the end result of polypharmacy as shown in the studies analyzed 11 - 57 , and are associated with others predictors, for example: sex differences 24 , 33 ; sex of patients, alcohol consumption and smoking habits 29 ; increased age 39 , 49 ; diagnoses of diseases and multiple comorbidities 21 , 25 , 48 - 49 , 53 ; use the specific types drugs, such as patients using clopidogrel with proton pump inhibitors 14 - 15 , tamoxifen 18 , co-prescription of macrolide antibiotics and calcium-channel blockers 23 ,trimethoprim/sulfamethoxazole 17 , 28 , 34 ,antidepressants 31 , 36 ,warfarin 38 , 45 , benzodiazepines 47 ; also, cognitive impairment and various functional problems that affect practical drug management capacity 24 - 25 ; living situation 19 ; access to health care, prescription of drug therapy regimens by two or more prescribers 49 ; and educational status 31 , 44 , 50 .…”

Section: Discussionmentioning

confidence: 99%

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Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review

Rodrigues

Oliveira

2016

Rev. Latino-Am. Enfermagem

126

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Objective: to identify and summarize studies examining both drug-drug interactions (DDI) and adverse drug reactions (ADR) in older adults polymedicated. Methods: an integrative review of studies published from January 2008 to December 2013, according to inclusion and exclusion criteria, in MEDLINE and EMBASE electronic databases were performed. Results: forty-seven full-text studies including 14,624,492 older adults (≥ 60 years) were analyzed: 24 (51.1%) concerning ADR, 14 (29.8%) DDI, and 9 studies (19.1%) investigating both DDI and ADR. We found a variety of methodological designs. The reviewed studies reinforced that polypharmacy is a multifactorial process, and predictors and inappropriate prescribing are associated with negative health outcomes, as increasing the frequency and types of ADRs and DDIs involving different drug classes, moreover, some studies show the most successful interventions to optimize prescribing. Conclusions: DDI and ADR among older adults continue to be a significant issue in the worldwide. The findings from the studies included in this integrative review, added to the previous reviews, can contribute to the improvement of advanced practices in geriatric nursing, to promote the safety of older patients in polypharmacy. However, more research is needed to elucidate gaps.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review

Rodrigues

Oliveira

2016

Rev. Latino-Am. Enfermagem

126

View full text Add to dashboard Cite

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“…Furthermore, daily hours of sleep may be influenced by the consumption of drugs such as benzodiazepines (BZD) since they are the most prescribed drugs to treat insomnia. It is estimated that 20–25% of the elderly consume them (Fernández et al, 2008 ) and nearly three-quarters of the elderly who use them are chronic users (Velert Vila et al, 2012 ). The BZD may cause adverse effects related to neurological disorders that could be added to the basic cognitive impairment in the elderly (Ranstam et al, 1997 ; Airagnes et al, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Decision Tree for Early Detection of Cognitive Impairment by Community Pharmacists

Climent¹,

Pardo

Muñoz-Almaraz

et al. 2018

Front. Pharmacol.

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Purpose: The early detection of Mild Cognitive Impairment (MCI) is essential in aging societies where dementia is becoming a common manifestation among the elderly. Thus our aim is to develop a decision tree to discriminate individuals at risk of MCI among non-institutionalized elderly users of community pharmacy. A more clinically and patient-oriented role of the community pharmacist in primary care makes the dispensation of medication an adequate situation for an effective, rapid, easy, and reproducible screening of MCI.Methods: A cross-sectional study was conducted with 728 non-institutionalized participants older than 65. A total of 167 variables were collected such as age, gender, educational attainment, daily sleep duration, reading frequency, subjective memory complaint, and medication. Two screening tests were used to detect possible MCI: Short Portable Mental State Questionnaire (SPMSQ) and the Mini-Mental State Examination (MMSE). Participants classified as positive were referred to clinical diagnosis. A decision tree and predictive models are presented as a result of applying techniques of machine learning for a more efficient enrollment.Results: One hundred and twenty-eight participants (17.4%) scored positive on MCI tests. A recursive partitioning algorithm with the most significant variables determined that the most relevant for the decision tree are: female sex, sleeping more than 9 h daily, age higher than 79 years as risk factors, and reading frequency. Moreover, psychoanaleptics, nootropics, and antidepressants, and anti-inflammatory drugs achieve a high score of importance according to the predictive algorithms. Furthermore, results obtained from these algorithms agree with the current research on MCI.Conclusion: Lifestyle-related factors such as sleep duration and the lack of reading habits are associated with the presence of positive in MCI test. Moreover, we have depicted how machine learning provides a sound methodology to produce tools for early detection of MCI in community pharmacy.Impact of findings on practice: The community of pharmacists provided with adequate tools could develop a crucial task in the early detection of MCI to redirect them immediately to the specialists in neurology or psychiatry. Pharmacists are one of the most accessible and regularly visited health care professionals and they can play a vital role in early detection of MCI.

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Role and impact of pharmacists in Spain: a scoping review

et al. 2018

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Adecuación de la utilización de benzodiazepinas en ancianos desde la oficina de farmacia. Un estudio de colaboración médico-farmacéutico

Abstract: The use of benzodiazepines in the Community of Valencia exceeds the recommendations of the Spanish Medicines Agency.

Cited by 18 publications

References 25 publications

Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review

Drug-drug interactions and adverse drug reactions in polypharmacy among older adults: an integrative review

Decision Tree for Early Detection of Cognitive Impairment by Community Pharmacists

Role and impact of pharmacists in Spain: a scoping review

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