Adducts formation at fullerenes C60 and C70 dissolution in essential oils

Konopelko, L. A.; Krilov, A. N.; Lopushanskaya, E. M.; Popov, Oleksandr

doi:10.1134/s1070363214020078

Cited by 3 publications

(1 citation statement)

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“…C60 was stirred in VOO for one week at room temperature due to high insolubility, covered with aluminium foil to avoid UV irradiation [10]. After one week of stirring, a cherry-red colour typical for C60-saturated vegetable oils was formed [21]. The food with VOO and/or VOO+C60 was prepared weekly.…”

Section: Groupsmentioning

confidence: 99%

Effects of C60 Fullerene on Thioacetamide-Induced Rat Liver Toxicity and Gut Microbiome Changes

et al. 2021

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Thioacetamide (TAA) is widely used to study liver toxicity accompanied by oxidative stress, inflammation, cell necrosis, fibrosis, cholestasis, and hepatocellular carcinoma. As an efficient free radical’s scavenger, C60 fullerene is considered a potential liver-protective agent in chemically-induced liver injury. In the present work, we examined the hepatoprotective effects of two C60 doses dissolved in virgin olive oil against TAA-induced hepatotoxicity in rats. We showed that TAA-induced increase in liver oxidative stress, judged by the changes in the activities of SOD, CAT, GPx, GR, GST, the content of GSH and 4-HNE, and expression of HO-1, MnSOD, and CuZnSOD, was more effectively ameliorated with a lower C60 dose. Improvement in liver antioxidative status caused by C60 was accompanied by a decrease in liver HMGB1 expression and an increase in nuclear Nrf2/NF-κB p65 ratio, suggesting a reduction in inflammation, necrosis and fibrosis. These results were in accordance with liver histology analysis, liver comet assay, and changes in serum levels of ALT, AST, and AP. The changes observed in gut microbiome support detrimental effects of TAA and hepatoprotective effects of low C60 dose. Less protective effects of a higher C60 dose could be a consequence of its enhanced aggregation and related pro-oxidant role.

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Section: Groupsmentioning

confidence: 99%