Addressing Unmet Clinical Needs with UV Bioadhesives

O’Rorke, Richard; Pokholenko, Oleksandr; Gao, Feng; Cheng, Ting; Shah, Ankur Harish; Mogal, Vishal; Steele, Terry W. J.

doi:10.1021/acs.biomac.6b01743

Cited by 38 publications

(36 citation statements)

References 85 publications

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“…In designing novel adhesives, research laboratories often do not consult the end‐users and these feasibility studies lack practicality . There is need for closer collaboration between researchers developing bioadhesives and clinicians to identify the unmet needs and establishing design priorities …”

Section: Future Outlookmentioning

confidence: 99%

Multifunctional Biomedical Adhesives

Pinnaratip

Bhuiyan

Meyers

et al. 2019

Adv Healthcare Materials

143

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Currently available biomedical adhesives are mainly engineered to have one function (i.e., providing mechanical support for the repaired tissue). To improve the performance of existing bioadhesives and broaden their applications in medicine, numerous multifunctional bioadhesives are reported in the literature. These adhesives can be categorized as passive or active by design. Passive multifunctional bioadhesives contain inherent compositions and structural designs that can carry out additional functions without added external influences. These adhesives exhibit new functionalities such as antimicrobial properties, self‐healing abilities, the ability to promote cellular ingrowth, and the ability to be reshaped. Conversely, active multifunctional bioadhesives respond to environmental changes (e.g., pH, temperature, electricity, light, and biomolecule concentration), which initiate a change in the adhesive to release encapsulated drugs or to activate or deactivate the bioadhesive for interfacial binding. This review article highlights recent advances in multifunctional bioadhesives.

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Section: Future Outlookmentioning

confidence: 99%

Multifunctional Biomedical Adhesives

Pinnaratip

Bhuiyan

Meyers

et al. 2019

Adv Healthcare Materials

143

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“…An ideal tissue adhesive must flow and adhere rapidly to the surface, conform to tissue shapes and resist deformation from mechanical stress, cause no toxicity, and be bioabsorbable [12]. For a tissue adhesive to be safe and effective, spatial and temporal control of the adhesive and cohesive strength is crucial [13]. Materials that show physical and chemical changes when exposed to light provide an opportunity to modulate material properties spatially and temporally [14,15].…”

Section: Introductionmentioning

confidence: 99%

Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

Narayanan

Dhinojwala

et al. 2020

ChemEngineering

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To stop blood loss and accelerate wound healing, conventional wound closure techniques such as sutures and staples are currently used in the clinic. These tissue-piercing wound closure techniques have several disadvantages such as the potential for causing inflammation, infections, and scar formation. Surgical sealants and tissue adhesives can address some of the disadvantages of current sutures and staples. An ideal tissue adhesive will demonstrate strong interfacial adhesion and cohesive strength to wet tissue surfaces. Most reported studies rely on the liquid-to-solid transition of organic molecules by taking advantage of polymerization and crosslinking reactions for improving the cohesive strength of the adhesives. Crosslinking reactions triggered using light are commonly used for increasing tissue adhesive strength since the reactions can be controlled spatially and temporally, providing the on-demand curing of the adhesives with minimum misplacements. In this review, we describe the recent advances in the field of naturally derived tissue adhesives and sealants in which the adhesive and cohesive strengths are modulated using photochemical reactions.

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“…Such formulations are considered to be useful to replace the suturing of delicate tissues and to avoid tissue piercing. This feature is particularly important for vascular anastomosis ( Figure 1 ) where adhesive formulations should allow strong tissue fixation in order to replace traditional suturing fixation methods [ 2 , 3 , 4 , 5 ].…”

Section: Introductionmentioning

confidence: 99%

On-Demand Bioadhesive Dendrimers with Reduced Cytotoxicity

et al. 2018

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Tissue adhesives based on polyamidoamine (PAMAM) dendrimer, grafted with UV-sensitive aryldiazirine (PAMAM-g-diazirine) are promising new candidates for light active adhesion on soft tissues. Diazirine carbene precursors form interfacial and intermolecular covalent crosslinks with tissues after UV light activation that requires no premixing or inclusion of free radical initiators. However, primary amines on the PAMAM dendrimer surface present a potential risk due to their cytotoxic and immunological effects. PAMAM-g-diazirine formulations with cationic pendant amines converted into neutral amide groups were evaluated. In vitro toxicity is reduced by an order of magnitude upon amine capping while retaining bioadhesive properties. The in vivo immunological response to PAMAM-g-diazirine formulations was found to be optimal in comparison to standard poly(lactic-co-glycolic acid) (PLGA) thin films.

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Addressing Unmet Clinical Needs with UV Bioadhesives

Cited by 38 publications

References 85 publications

Multifunctional Biomedical Adhesives

Multifunctional Biomedical Adhesives

Advances in Photoreactive Tissue Adhesives Derived from Natural Polymers

On-Demand Bioadhesive Dendrimers with Reduced Cytotoxicity

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