Addressing tuberculosis through complex community-based socioeconomic interventions in low- and middle-income countries: A systematic realist review

Bustos, Monica; Luu, Kathy; Lau, Lincoln Leehang; Dodd, Warren

doi:10.1080/17441692.2021.1966487

Cited by 5 publications

(4 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secure, adequate, and sustainable funding with robust infrastructure was reported as essential for successful implementation of social protection interventions. 71 Importantly, these factors dictate both what programs people with TB and their households can access and also how they are able to access these programs. Further, adequate funding will be necessary to ensure cash transfers sufficiently mitigate the costs associated with TB illness and care.…”

Section: Discussionmentioning

confidence: 99%

“…7 Realistic operationalization of social protection programs is discussed by Bustos et al., who noted that successful social protection programs rely on a network of groups in socio-political, relational, and operational contexts. 71 In light of this, better process evaluation and implementation research is required in this field to support integration of social protection into routine practice and scale-up at national level.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Social Protection Interventions for TB-Affected Households: A Scoping Review

Todd

Hudson

Grolmusova

et al. 2023

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

Tuberculosis (TB) and poverty are inextricably linked. Catastrophic costs of TB illness drive TB-affected households into worsening impoverishment and hamper treatment success. The WHO’s End TB Strategy recommends social protection for TB-affected households to mitigate financial shock and improve TB outcomes. This scoping review maps the landscape of social protection interventions for people with TB and their households in low- and middle-income countries with high TB burden. A systematic search of Medline, Embase, PubMed, and Web of Science for relevant articles was performed, supplemented with a gray literature search of key databases. Articles were included if they described social protection available to people with TB and TB-affected households in a low- or middle-income country. Data were synthesized in tabular form, and descriptive narrative outlined the successes and challenges of the social protection interventions identified. The search identified 33,360 articles. After abstract screening, 74 articles underwent full text screening, and 49 were included in the final analysis. Forty-three types of social protection were identified, of which 24 were TB specific (i.e., only people with TB were eligible). Varying definitions were used to describe similar social protection interventions, which limited cross-study comparison. Intervention successes included acceptability and increased financial autonomy among recipients. Challenges included delays in intervention delivery and unexpected additional bank transfer fees. A wide range of acceptable social protection interventions are available, with cash transfer schemes predominating. Use of standardized definitions of social protection interventions would facilitate consolidation of evidence and enhance design and implementation in future.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Social Protection Interventions for TB-Affected Households: A Scoping Review

Todd

Hudson

Grolmusova

et al. 2023

The American Journal of Tropical Medicine and Hygiene

View full text Add to dashboard Cite

show abstract

“…40% ( n = 37) of the realist reviews cited use of an advisory group at some stage (as per the working definition for this study, notably other terminology was often reported) [14–17, 25–61]. 60% ( n = 56) did not mention the use of an advisory group [62–117]. Of those that did not mention an advisory group, seven reviews [62–64] did report participant involvement that did not fulfill the criteria of an advisory group, i.e., participants were used as data sources but did not advise on the review.…”

Section: Resultsmentioning

confidence: 99%

Advisory groups in realist reviews: Systematically mapping current research and recommendations for practice

Power,

Dada,

Booth

et al. 2024

Cochrane Evidence Synthesis and Methods

View full text Add to dashboard Cite

IntroductionRealist reviews may involve groups or panels external to the research team who provide external and independent perspectives informing the review based on their experience of the topic area. These panels or groups are termed in this study as an “advisory group.” This study aims to map current practice of advisory groups in realist reviews and provide guidance for planning and reporting.MethodsA “best‐fit” framework synthesis methodology was used by first searching for a best‐fit framework and then conducting a systematic search to identify a sample of realist reviews and rapid realist reviews (RRRs) from the most recent year, 2021. Nine databases were searched: CINAHL Complete, Cochrane, Embase, ERIC, MEDLINE, PsycInfo, Social Services Abstracts, Sociological Abstracts, and Web of Science Core Collection. Screening and data extraction was conducted by two researchers. The chosen best‐fit framework (ACTIVE framework) informed the data extraction tool.ResultsOne hundred and seven reviews (93 realist reviews, 14 RRRs) were identified for inclusion. Of these, 40% (n = 37) of realist reviews and 71.5% (n = 10) of RRRs mentioned use of an advisory group, though there was considerable variation in terminology used. Individuals in advisory groups were involved at varying stages of the review and tended to bring experience in the topic area from the perspective of (i) a lived experience, i.e., patients, carers, family members (n = 15 realist reviews; n = 4 RRRs); (ii) professional experience, such as healthcare professionals (n = 20 realist reviews; n = 6 RRRs); or (iii) policy or research experience in the topic area (n = 19 realist reviews; n = 7 RRRs).ConclusionsThis study proposes a definition of advisory groups, considerations for advisory group use, and suggested items for reporting. The purpose of the advisory group should be carefully considered when deciding on their use in a realist review.

show abstract

“…TB is one of the top 15 causes of death worldwide, with a mortality of 1.3 million people in 2022 [ 1 ]. The disease has a significant presence in low- and middle-income countries, over 80% of cases and deaths occur there, due to socio-economic factors such as poverty, malnutrition, and inadequate healthcare systems [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Redefining Peptide 14D: Substitutional Analysis for Accelerated TB Diagnosis and Enhanced Activity against Mycobacterium tuberculosis

Hilpert,

Munshi,

López-Pérez

et al. 2024

Microorganisms

View full text Add to dashboard Cite

Tuberculosis (TB) caused by Mycobacterium tuberculosis remains a predominant cause of mortality, especially in low- and middle-income nations. Recently, antimicrobial peptides have been discovered that at low concentrations could stimulate the growth of M. tuberculosis (hormetic response). In this study, such a peptide was used to investigate the effects on the time to positivity (TTP). A systematic substitution analysis of peptide 14D was synthesized using Spot synthesis technology, resulting in 171 novel peptides. Our findings revealed a spectrum of interactions, with some peptides accelerating M. tuberculosis growth, potentially aiding in faster diagnostics, while others exhibited inhibitory effects. Notably, peptide NH2-wkivfiwrr-CONH2 significantly reduced the TTP by 25 h compared to the wild-type peptide 14D, highlighting its potential in improving TB diagnostics by culture. Several peptides demonstrated potent antimycobacterial activity, with a minimum inhibitory concentration (MIC) of 20 µg/mL against H37Rv and a multidrug-resistant M. tuberculosis strain. Additionally, for two peptides, a strongly diminished formation of cord-like structures was observed, which is indicative of reduced virulence and transmission potential. This study underscores the multifaceted roles of antimicrobial peptides in TB management, from enhancing diagnostic efficiency to offering therapeutic avenues against M. tuberculosis.

show abstract

Addressing tuberculosis through complex community-based socioeconomic interventions in low- and middle-income countries: A systematic realist review

Cited by 5 publications

References 58 publications

Social Protection Interventions for TB-Affected Households: A Scoping Review

Social Protection Interventions for TB-Affected Households: A Scoping Review

Advisory groups in realist reviews: Systematically mapping current research and recommendations for practice

Redefining Peptide 14D: Substitutional Analysis for Accelerated TB Diagnosis and Enhanced Activity against Mycobacterium tuberculosis

Contact Info

Product

Resources

About