Addressing the gaps between socioeconomic disparities and biological models of dementia

Ibáñez, Agustín; Legaz, Agustina; Reina, Manuel Ruiz-Adame

doi:10.1093/brain/awad236

Cited by 26 publications

(27 citation statements)

References 9 publications

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“…Brain health, ageing and dementia are influenced by various heterogeneous factors, which do not exhibit universal applicability across diverse contexts 1–8 . Variability in genetics, pathophysiological pathways, clinical presentations, aetiology and exposome is non‐homogeneous across geographical regions 2,9 .…”

Section: Brain Health Ageing and Dementia Through The Lenses Of Diver...mentioning

confidence: 99%

“…Incorporating genetic and imaging methods alongside locally validated clinical protocols is essential to address diversity effectively 2 . Also, harmonisation frameworks across various disciplines, including epidemiology, clinical research, basic neuroscience and social sciences, are critically needed to provide a comprehensive understanding of the interplay between environmental and biological factors 4,5 . Identifying the most effective interventions for dementia in diverse sociocultural contexts of the Global South is crucial.…”

Section: Brain Health Ageing and Dementia Through The Lenses Of Diver...mentioning

confidence: 99%

“…2 Also, harmonisation frameworks across various disciplines, including epidemiology, clinical research, basic neuroscience and social sciences, are critically needed to provide a comprehensive understanding of the interplay between environmental and biological factors. 4,5 Identifying the most effective interventions for dementia in diverse sociocultural contexts of the Global South is crucial. This approach can provide more robust predictive models for brain health and ageing, as well as potential treatments for dementia tailored to the specific needs of diverse populations.…”

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confidence: 99%

“…Brain health, ageing and dementia are influenced by various heterogeneous factors, which do not exhibit universal applicability across diverse contexts. [1][2][3][4][5][6][7][8] Variability in genetics, pathophysiological pathways, clinical presentations, aetiology and exposome is non-homogeneous across geographical regions. 2,9 Additionally, unequal epidemiological patterns related to risk and protective factors, social determinants of health (SDH), socioeconomic disparities and healthcare access play important roles in brain health.…”

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confidence: 99%

“…1 To develop customised preventive measures, public health and clinical sciences leaders should recognise the complex interplay of disparity-related factors, including individual health indicators and SDH from a local setting. 4,5 This tailored approach represents the foundation for shaping policies that yield synergistic benefits across various aspects of brain health, ageing and dementia (See Figure 1)…”

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confidence: 99%

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Global South research is critical for understanding brain health, ageing and dementia

Baez,

Alladi,

Ibanez

2023

Clinical & Translational Med

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Section: Brain Health Ageing and Dementia Through The Lenses Of Diver...mentioning

confidence: 99%

Section: Brain Health Ageing and Dementia Through The Lenses Of Diver...mentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Global South research is critical for understanding brain health, ageing and dementia

Baez,

Alladi,

Ibanez

2023

Clinical & Translational Med

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Walking the talk for dementia: A unique immersive, embodied, and multi‐experiential initiative

Aguzzoli Peres,

Haas,

Martha

et al. 2024

Alzheimer's & Dementia

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Coping with dementia requires an integrated approach encompassing personal, health, research, and community domains. Here we describe “Walking the Talk for Dementia,” an immersive initiative aimed at empowering people with dementia, enhancing dementia understanding, and inspiring collaborations. This initiative involved 300 participants from 25 nationalities, including people with dementia, care partners, clinicians, policymakers, researchers, and advocates for a 4‐day, 40 km walk through the Camino de Santiago de Compostela, Spain. A 2‐day symposium after the journey provided novel transdisciplinary and horizontal structures, deconstructing traditional hierarchies. The innovation of this initiative lies in its ability to merge a physical experience with knowledge exchange for diversifying individuals' understanding of dementia. It showcases the transformative potential of an immersive, embodied, and multi‐experiential approach to address the complexities of dementia collaboratively. The initiative offers a scalable model to enhance understanding, decrease stigma, and promote more comprehensive and empathetic dementia care and research.

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Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling

Coronel‐Oliveros,

Gómez,

Ranasinghe

et al. 2024

Alzheimer's & Dementia

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INTRODUCTIONAlzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) lack mechanistic biophysical modeling in diverse, underrepresented populations. Electroencephalography (EEG) is a high temporal resolution, cost‐effective technique for studying dementia globally, but lacks mechanistic models and produces non‐replicable results.METHODSWe developed a generative whole‐brain model that combines EEG source‐level metaconnectivity, anatomical priors, and a perturbational approach. This model was applied to Global South participants (AD, bvFTD, and healthy controls).RESULTSMetaconnectivity outperformed pairwise connectivity and revealed more viscous dynamics in patients, with altered metaconnectivity patterns associated with multimodal disease presentation. The biophysical model showed that connectome disintegration and hypoexcitability triggered altered metaconnectivity dynamics and identified critical regions for brain stimulation. We replicated the main results in a second subset of participants for validation with unharmonized, heterogeneous recording settings.DISCUSSIONThe results provide a novel agenda for developing mechanistic model‐inspired characterization and therapies in clinical, translational, and computational neuroscience settings.

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Addressing the gaps between socioeconomic disparities and biological models of dementia

Cited by 26 publications

References 9 publications

Global South research is critical for understanding brain health, ageing and dementia

Global South research is critical for understanding brain health, ageing and dementia

Walking the talk for dementia: A unique immersive, embodied, and multi‐experiential initiative

Viscous dynamics associated with hypoexcitation and structural disintegration in neurodegeneration via generative whole‐brain modeling

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