In August 2017, a local outbreak of Hepatitis A was identified among homeless individuals in Louisville, Kentucky. This marked the first cases in what has now become recognized as the largest Hepatitis A outbreak in the US [Warren, 2018]. In the midst of the changing epidemiology of this disease, Kentucky joins a growing number of other states in a larger nationwide public health concern [KDPH, 2018]. Cornerstones in disruption of this outbreak include immunization and education regarding the disease and its transmission opportunities for all at risk. Hepatitis A is a communicable disease transmitted via ingestion of the organism that is found in feces of an infected individual. Hepatitis A impacts the liver and as the virus replicates, it is shed in the stool. Risk factors for both acquisition and transmission of infection include those who are homeless or housing insecure, persons who use drugs, men who have sex with men, or those who have close contact with these persons described [CDC, 2018a]. Due to various social determinants of care in populations facing homelessness and substance abuse, challenges exist in engaging those at risk to provide vaccination and education regarding transmission and prevention of infectious diseases. The first confirmed cases of Hepatitis A infection in Kentucky were reported in Louisville, and initial vaccination efforts targeted the homeless and persons who use drugs, but as the outbreak progressed the vaccination outreach efforts broadened. In December, 2017 the first case of Hepatitis A was reported in an individual working in the food service industry in Louisville [KDPH, 2018]. This case highlighted the importance of considering food as a source of transmission as well as those