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2016
DOI: 10.1136/bmjgh-2016-000132
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Addressing the challenges of diagnostics demand and supply: insights from an online global health discussion platform

Abstract: Several barriers challenge development, adoption and scale-up of diagnostics in low and middle income countries. An innovative global health discussion platform allows capturing insights from the global health community on factors driving demand and supply for diagnostics. We conducted a qualitative content analysis of the online discussion ‘Advancing Care Delivery: Driving Demand and Supply of Diagnostics’ organised by the Global Health Delivery Project (GHD) (http://www.ghdonline.org/) at Harvard University.… Show more

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Cited by 59 publications
(95 citation statements)
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References 16 publications
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“…Given that elements such as manufacturability, cost, distribution and product support greatly affect success, it is vital at this stage to consult delivery stakeholders (manufacturers if different from developer, procurers and distributors) to create realistic TPPs that are well aligned with the real implementation and scale-up needs 6. For example, challenges around affordability might require developers to explore technologies and formats with very low manufacturing costs in order to deliver the required product performance at significantly lower prices.…”
Section: Product Feasibility Definition and Planningmentioning
confidence: 99%
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“…Given that elements such as manufacturability, cost, distribution and product support greatly affect success, it is vital at this stage to consult delivery stakeholders (manufacturers if different from developer, procurers and distributors) to create realistic TPPs that are well aligned with the real implementation and scale-up needs 6. For example, challenges around affordability might require developers to explore technologies and formats with very low manufacturing costs in order to deliver the required product performance at significantly lower prices.…”
Section: Product Feasibility Definition and Planningmentioning
confidence: 99%
“…During the design process, the developer identifies an optimal product design that closely meets the desired performance specifications. End users and other stakeholders can provide valuable feedback on the prototype instrument in order to refine its design 6 24. In some cases, the relative importance of different features may need to be reassessed and used to make decisions on product design priorities.…”
Section: Design Development and Transfer To Manufacturingmentioning
confidence: 99%
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“…Recent advances in bacteria preconcentration and the diagnosis of TB and multi-drug resistant tuberculosis (MDR-TB) include sophisticated techniques such as Xpert MTB/RIF, TB beads, liquid culture, centrifugation, filtration, and line probe assays [43][44][45][46][47]. However, these techniques are not necessarily accessible or affordable for those who need them the most [48]. Considering the high accuracy (~97%) and specificity (~99%) of the Xpert system relative to the culture standard [36], the World Health Organization issued a recommendation in 2010 to use Xpert MTB/RIF for the diagnosis of all persons with signs and symptoms of TB.…”
Section: Early Assessment Of Tuberculosis In Vulnerable Populationsmentioning
confidence: 99%
“…While these immunodiagnostic technologies are relatively unsophisticated, development of sensitive and specific antibodies and antigens required for an immunoassay is often a rate-limiting step. These immunodiagnostic reagents must be sensitive, specific, robust, and most importantly, sustainable (4).…”
Section: Introductionmentioning
confidence: 99%