Addressing positive multi-cancer early detection tests in head and neck Surgery: Experience with head and neck work up for high-risk referrals

Fearington, Forrest W.; Zhao, Conan Y.; Romero-Brufau, Santiago; Moore, Eric J.; Price, Daniel L.; Tasche, Kendall K.; Yin, Linda X.; Kunkel, Elizabeth T.; Kisiel, John B.; Giridhar, Karthik V.; Routman, David M.; Van Abel, Kathryn M.

doi:10.1016/j.oraloncology.2024.106809

Oral Oncology

2024

DOI: 10.1016/j.oraloncology.2024.106809

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Addressing positive multi-cancer early detection tests in head and neck Surgery: Experience with head and neck work up for high-risk referrals

Forrest W. Fearington,

Conan Y. Zhao,

Santiago Romero-Brufau

et al.

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Multicancer Early Detection Tests: A State‐of‐the‐Art Review for Otolaryngologists

Kennedy,

Durm,

Farlow

2024

OTO Open

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ObjectiveTo provide a review of the science and applicability of current multi‐cancer early detection (MCED) tests for otolaryngologists.Data SourcesPubMed, clinicaltrials.gov, company websites.Review MethodsUsing PRISMA methodology, primary literature regarding MCED tests was queried from April 26 to May 12, 2024 using MCED search terms. Ongoing clinical trials incorporating MCED screens were identified via the National Institutes of Health clinicaltrials.gov website. Company websites for available or upcoming MCED tests were reviewed.ConclusionLong‐term robust data regarding the performance characteristics, effects on clinical outcomes, and cost‐utility of MCED tests for head and neck cancer are currently lacking. Otolaryngologists should be aware of the implications of MCED tests as these assays become more widely used.Implications for PracticeAlthough not FDA‐approved or covered by insurances at the time of writing of this manuscript, MCED testing is rapidly gaining interest, and patients with positive tests are presenting to otolaryngologists for evaluation. While MCED technologies hold great promise for early detection of disease and potential reduction of morbidity and mortality, more study is needed about their utility for head and neck cancer and optimal diagnostic workflows.

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Multicancer Early Detection Tests: A State‐of‐the‐Art Review for Otolaryngologists

Kennedy,

Durm,

Farlow

2024

OTO Open

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Addressing positive multi-cancer early detection tests in head and neck Surgery: Experience with head and neck work up for high-risk referrals

Cited by 1 publication

References 39 publications

Multicancer Early Detection Tests: A State‐of‐the‐Art Review for Otolaryngologists

Multicancer Early Detection Tests: A State‐of‐the‐Art Review for Otolaryngologists

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