2020
DOI: 10.3390/ijms21228854
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Addressing Latent Tuberculosis: New Advances in Mimicking the Disease, Discovering Key Targets, and Designing Hit Compounds

Abstract: Despite being discovered and isolated more than one hundred years ago, tuberculosis (TB) remains a global public health concern arch. Our inability to eradicate this bacillus is strongly related with the growing resistance, low compliance to current drugs, and the capacity of the bacteria to coexist in a state of asymptomatic latency. This last state can be sustained for years or even decades, waiting for a breach in the immune system to become active again. Furthermore, most current therapies are not efficaci… Show more

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Cited by 11 publications
(10 citation statements)
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References 180 publications
(255 reference statements)
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“…Identifying specific markers peculiar to patients with latent TB would be beneficial to tackling this challenge. The use of bioinformatics, and the other ‘omics' disciplines, have proved able to identify several potential targets for the survival of Mtb in the latently infected host ( 163 165 ).…”
Section: Discussionmentioning
confidence: 99%
“…Identifying specific markers peculiar to patients with latent TB would be beneficial to tackling this challenge. The use of bioinformatics, and the other ‘omics' disciplines, have proved able to identify several potential targets for the survival of Mtb in the latently infected host ( 163 165 ).…”
Section: Discussionmentioning
confidence: 99%
“…Granulomas play an important role in arresting the growth and proliferation of Mtb cells. Inside granulomas, they are faced with hypoxia, a lack of nutrients, and high concentrations of nitric oxide [ 50 ]. However, they can survive in these conditions due to their transition to the dormant state and persisting even during the anti-TB chemotherapy [ 3 , 50 , 51 , 52 ].…”
Section: Regulation Of Mtb Dormancymentioning
confidence: 99%
“…Inside granulomas, they are faced with hypoxia, a lack of nutrients, and high concentrations of nitric oxide [ 50 ]. However, they can survive in these conditions due to their transition to the dormant state and persisting even during the anti-TB chemotherapy [ 3 , 50 , 51 , 52 ]. Stress conditions in granulomas lead to the metabolic heterogeneity of Mtb [ 44 , 53 ].…”
Section: Regulation Of Mtb Dormancymentioning
confidence: 99%
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