Addressing gaps in international blood availability and transfusion safety in low‐ and middle‐income countries: a NHLBI workshop

Custer, Brian; Zou, Shimian; Glynn, Simone A.; Makani, Julie; Tagny, Claude Tayou; Ekiaby, Magdy El; Sabino, Éster Cerdeira; Choudhury, Nikumani; Teo, Diana; Nelson, Kenrad E.; Peprah, Emmanuel; Price, LeShawndra N.; Engelgau, Michael M.

doi:10.1111/trf.14598

Cited by 68 publications

(73 citation statements)

References 60 publications

(93 reference statements)

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“…Thus, professionals and authorities in the transfusion medicine field struggle to request and negotiate budgets that allow them to increase the number of donations and simultaneously strengthening the infectious and immunological safety levels. To achieve that some register in accreditation programs (Table ) that allow sustainable progresses; nevertheless, the improved quality management shows persisting gaps in safety measures …”

Section: Discussionmentioning

confidence: 99%

“…To achieve that some register in accreditation programs ( Table 2) that allow sustainable progresses; nevertheless, the improved quality management shows persisting gaps in safety measures. 7,13,14 Thanks to a number of initiatives (WHO, ISBT, AABB, EMITm…);…”

Section: F I G U R E 1 Correlation Between Gdp Per Capita and Rate Ofmentioning

confidence: 99%

“…Some countries even collaborate with Western institutions for this purpose (eg, Egypt, Lebanon, Morocco) . The progress made as well as the continuing gaps are evidenced in several reports, mainly the one from the WHO Regional Committee for the Eastern Mediterranean …”

Section: Introductionmentioning

confidence: 99%

“…12 The progress made as well as the continuing gaps are evidenced in several reports, mainly the one from the WHO Regional Committee for the Eastern Mediterranean. 7,13,14 Having considered that all these standards are resource consuming at a time resource (and cooperation support from Northern/Western countries) are becoming scarce, 15 we endeavoured to collect information from Eastern/Southern countries of the Mediterranean area on how they handle and manage all aspects of the transfusion process from donor to recipient. The primary objective of this original work was to enlist success stories, but also fails when present, to ultimately share methods with others and preserve resources.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

How to manage transfusion systems in developing countries: The Experience of Eastern and Southern Mediterranean countries

Haddad

Benajiba²,

Hmida³

et al. 2020

Transfusion Medicine

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Objectives To outline and analyse the national organisation, infrastructure and management of transfusion systems in countries sharing common historical, cultural and economic features and to decipher management trends, in order to potentially benchmark. Background Little is known regarding transfusion systems in Eastern/southern Mediterranean at a time international organisations are calling for the establishment of a safe and sustainable blood system. Materials and Methods Data emanating from eight Arabic‐speaking Eastern/Southern Mediterranean countries who responded to five surveys were collected and tabulated. Results While similarities in terms of supervision by national authorities, authorization of blood centres, quality control and management information system are evident, some significant divergence between these countries do exists. Only Lebanon does not possess a national blood establishment or organisation for blood supply. Blood components are fully government‐subsidised in Algeria and Mauritania. Algeria, Morocco and Tunisia have a blood supply that relies mainly on Voluntary non‐remunerated donors. Plateletpheresis is performed in all countries except Mauritania while plasmapheresis exists only in Algeria and Egypt. Morocco is the sole country outsourcing its plasma for Plasma derived products. Conclusion Despite the various challenges facing these countries, lot of progresses have been made so far in the field of transfusion medicine. Yet, nationally coordinated blood programs overviewed by national regulatory authorities and actively supported by local governments are still needed to ensure the optimum level of blood safety.

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Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 1 Correlation Between Gdp Per Capita and Rate Ofmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

How to manage transfusion systems in developing countries: The Experience of Eastern and Southern Mediterranean countries

Haddad

Benajiba²,

Hmida³

et al. 2020

Transfusion Medicine

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“…Current investigational priorities relate to safety (PI, hospital transfusion services [guidelines, haemovigilance]), sufficiency (best donor recruitment strategies, needs modelling and stock management) and sustainability . In SMA, the best triggers (amid current risks), dose, infusion pace, format (whole blood or RBC, ±PI), matching (ABO type‐specific or O) and target (to restore O 2 delivery without excess iRBC biomass expansion) are yet to be clarified.…”

Section: Haemotherapy Of Severe Malariamentioning

confidence: 99%

NONE TOO S.M.A.LL: the global challenge of severe malarial anaemia and its transfusion support

Cserti‐Gazdewich

2018

ISBT Science Series

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In endemic areas, the burden of malaria and anaemia converge together upon children, with severe malarial anaemia (SMA) accounting disproportionately for demands on limited blood supplies. The attributable morbidity and mortality from SMA remain high, and improved outcomes hinge in part on the timeliness, sufficiency and safety of transfusion support. The pathogenesis of SMA is complex, and depreciation kinetics (towards syndrome‐defining haemoglobin levels of <50 g/l) occur acutely or insidiously, and in relation to the parasite burden and host response. Beyond haemolysis of parasitized erythrocytes, mechanisms of bystander loss and reduced erythropoiesis figure prominently, with parallels to hyperhaemolysis syndrome. Involuntarily undertransfused children with SMA in low‐income countries (LIC) differ from those adults in high‐income countries (HIC) who deliberately renounce transfusion. Despite youth‐related advantages in the power to adapt to anaemia, critical reductions in oxygen‐carrying capacity illustrate the hierarchical impacts of organ anoxia, be it in terminal cardiorespiratory events or irreversible neurocognitive impairments in survivors. When resources permit, the dynamics of restored oxygen delivery by transfusion are particularly observable in SMA, as the triggers to transfuse are so much lower (and the odds of corresponding lactic acidosis are so much higher) than in HICs. Questions on the best haemotherapy approaches to SMA remain, be these in dosage, infusion rate, component preparation or matching options; these fundamental concerns now transcend those related to storage duration. As a persisting global scourge, SMA therefore keeps driving and facing the mandate to bank life‐preserving blood for those with the most to gain (and otherwise lose).

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Dangerous shortage of blood banks as an indirect effect of SARS‐CoV‐2: An obstetrics perspective

Nieto-Calvache

Quintero-Santacruz

Macia-Mejia

et al. 2020

Intl J Gynecology & Obste

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Objective: To describe the impact of the SARS-CoV-2 pandemic on the frequency of blood donation (BD) in a Latin American hospital and how the social isolation policy implemented during the pandemic jeopardizes the quality of postpartum hemorrhage (PPH) care due to shortages at blood banks (BB). Methods: A retrospective, descriptive study was conducted, lasting for 31 months, including the start of the pandemic. Frequency of BD and the use of obstetric emergency services was observed. Results: A direct relationship was observed between the pandemic and a decrease in BD. Although emergency obstetric visits decreased, the frequency of deliveries and cases of PPH remained unchanged. After applying strategies to promote voluntary BD, a very slight increase was observed in the frequency of BD, with a negative indicator persisting between donation and blood demand. Conclusion: The SARS-CoV-2 pandemic has led to shortages at BBs. In this context, typical measures to encourage an altruistic attitude toward BD have not had a significant impact. As causes of PPH continue, quality of care may be affected by the current situation at BBs. Governments and institutions must implement new strategies to motivate BD.

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Addressing gaps in international blood availability and transfusion safety in low‐ and middle‐income countries: a NHLBI workshop

Cited by 68 publications

References 60 publications

How to manage transfusion systems in developing countries: The Experience of Eastern and Southern Mediterranean countries

How to manage transfusion systems in developing countries: The Experience of Eastern and Southern Mediterranean countries

NONE TOO S.M.A.LL: the global challenge of severe malarial anaemia and its transfusion support

Dangerous shortage of blood banks as an indirect effect of SARS‐CoV‐2: An obstetrics perspective

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