Addressing cancer-related fatigue through sleep: A secondary analysis of a randomized trial comparing acupuncture and cognitive behavioral therapy for insomnia

Li, Xiaotong; Liou, Kevin T; Chimonas, Susan; Bryl, Karolina; Wong, Greta; Spiguel, Eugenie; Li, Susan Q.; Garland, Sheila N.; Bao, Ting; Mao, Jun J.

doi:10.1016/j.imr.2023.100922

Cited by 5 publications

(7 citation statements)

References 60 publications

(72 reference statements)

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“…The high number of citations may be due to the fact that it was published in the journal "Cancer Nursing" where pioneering and high quality studies are published. Given the number of published articles on cancer, fatigue, quality of life, symptom management have been the topic of interest for many researchers [30,31,32,33]. Studies emphasize that cancer-related symptoms are frequent and co-occur.…”

Section: Discussionmentioning

confidence: 99%

Global Trends and Emerging Hotspots in Cancer-Related Fatigue: A Comprehensive Bibliometric and Visual Analysis in Nursing Research

YILDIRIM,

SEZGIN,

KOCAKOÇ

2024

Preprint

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Purpose:The aim of the study was to examine the hotspots and global trends of cancer-related fatigue in nursing research. Methods:We searched the Web of Science database for relevant articles concerning cancer-related fatigue in nursing research, published between 1997 and 2023. Data collected include: the number of publications, authors, journals, countries, institutions, keywords. VOSviewer and CiteSpace were used to conduct the bibliometric study and visualise the analysis. Results:A total of 405 publications were included. The number of publications on cancer-related fatigue in nursing research shows a fluctuating upward trend. The journal of Cancer Nursing published the most articles on cancer-related fatigue in nursing research (66 publications). The United States of America published the most articles (215 published). The research institution with the highest number of publications is the University of California in San Francisco. According to word cloud of keyword, we believe that “Quality of Life”, “Pain”, “Breast Cancer” and “Depression” may be new research hotspots in the field of cancer-related fatigue in nursing research. Conclusion:This study describes the research status of cancer-related fatigue in nursing research over the past 26 years. Our findings illuminate the increasing interdisicilinary interest in cancer-related fatigue, signaling a shift towards more holistic and patient-centered research approaches in nursing, with significant potential to inform future clinical practices and policies.

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Section: Discussionmentioning

confidence: 99%

Global Trends and Emerging Hotspots in Cancer-Related Fatigue: A Comprehensive Bibliometric and Visual Analysis in Nursing Research

YILDIRIM,

SEZGIN,

KOCAKOÇ

2024

Preprint

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“…51 We demonstrate that change in perceived cognitive function was fully mediated by improvement in insomnia, suggesting a mechanistic understanding of the effect of CBT-I on subjectively-assessed cognitive functioning. Given the evidence for the benefits of CBT-I on fatigue, 52,53 pain, 54 depression, 55 QoL, 56 and now cognitive functioning, there is an urgent need to increase access to CBT-I for cancer survivors.…”

Section: Discussionmentioning

confidence: 99%

Randomized Controlled Trial of Virtually Delivered Cognitive Behavioral Therapy for Insomnia to Address Perceived Cancer-Related Cognitive Impairment in Cancer Survivors

Garland,

Tulk,

Savard

et al. 2024

JCO

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PURPOSE Comorbid insomnia and cancer-related cognitive impairment (CRCI) are experienced by up to 26% of individuals diagnosed with cancer. This study examined the efficacy and durability of cognitive behavioral therapy for insomnia (CBT-I) on perceived CRCI in cancer survivors. METHODS Atlantic Canadian cancer survivors with insomnia and CRCI were randomly assigned to receive seven weekly virtual CBT-I sessions (n = 63) or placed in a waitlist control group (n = 69) to receive treatment after the waiting period. Participants completed assessments at baseline, 1 month (mid-treatment), and 2 months (post-treatment). Age- and education-adjusted mixed-effects models using intention-to-treat principles assessed change at post-treatment. Data from both groups were then pooled to assess the durability of effects at 3 and 6 months. A mediation analysis examined whether change in insomnia symptoms mediated the effect of CBT-I on cognitive outcomes. RESULTS The mean age of the sample was 60 years, 77% were women, and breast cancer was the most common diagnosis (41%). The treatment group reported an 11.35-point reduction in insomnia severity, compared with a 2.67-point reduction in the waitlist control group ( P < .001). The treatment group had a greater overall improvement than the waitlist control on perceived cognitive impairment ( P < .001; d = 0.75), cognitive abilities ( P < .001; d = 0.92), and impact on quality of life ( P < .001; d = 1.01). These improvements were maintained at follow-up. Change in insomnia symptoms fully mediated the effect of CBT-I on subjective cognitive outcomes. CONCLUSION Treating insomnia with CBT-I produces clinically meaningful and durable improvements in CRCI. There is an urgent need increase access to evidence-based treatment for insomnia in cancer centers and the community.

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“…21 Among four common types of latent classes across prostate, lung, non-Hodgkin's lymphoma, and breast cancers in our study, pain, and depression were associated with fatigue and sleep disturbances. Numerous studies in the literature have indicated a robust correlation between depression, fatigue, and sleep disturbances in cancer survivors [25][26][27]. Cancer-related fatigue is a distressing and persistent symptom frequently experienced by cancer survivors, often resulting from disrupted sleep patterns [26,27].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies in the literature have indicated a robust correlation between depression, fatigue, and sleep disturbances in cancer survivors [25][26][27]. Cancer-related fatigue is a distressing and persistent symptom frequently experienced by cancer survivors, often resulting from disrupted sleep patterns [26,27]. The prevalence of fatigue and depression in cancer patients has been extensively researched, with a signi cant number of survivors reporting elevated depressive symptoms and experiencing fatigue [25].…”

Section: Discussionmentioning

confidence: 99%

“…The prevalence of fatigue and depression in cancer patients has been extensively researched, with a signi cant number of survivors reporting elevated depressive symptoms and experiencing fatigue [25]. Additionally, sleep disturbances are common among cancer patients, and studies have shown that these symptoms tend to co-occur, implying a potential shared underlying mechanism [27]. One possible explanation for this association is the activation of the proin ammatory cytokine network related to systemic in ammation, which has been linked to fatigue, depression, and sleep disturbances in cancer patients [28].…”

Section: Discussionmentioning

confidence: 99%

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Comparing Symptom Clusters in Cancer Survivors by Cancer Diagnosis: A Latent Class Profile Analysis

Lee,

Han,

Saligan

et al. 2023

Preprint

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Purpose: Research on symptom clusters in oncology is progressing, but knowledge gaps remain. One question is whether the number and types of Symptom Subgroups differ based on cancer diagnosis. However, no research has compared Symptom Subgroups in heterogeneous populations based on cancer diagnosis. The purpose of this study was to: (1) identify the clustering of four highly prevalent symptoms (pain, fatigue, sleep disturbance, and depression), and (2) compare symptom clusters across the seven populations of cancer survivors (prostate, non-small cell lung, non-Hodgkin’s lymphoma, breast, uterine, cervical, and colorectal cancer). Methods: This study is a cross-sectional secondary analysis of data obtained from the My-Health study in partnership with four Surveillance, Epidemiology, and End Results (SEER) cancer registries located in California (two), Louisiana, and New Jersey. The sample included 4,762 cancer survivors 6-13 months following diagnosis of one of the seven cancer types mentioned. Latent class profile analysis was used. Results: Subjects were primarily young (59% age 21-64 years), Caucasian (41%), married/cohabitating (58%) and unemployed (55%). The number of symptom subgroups varied across these seven cancer populations: (1) four-class solution in prostate, lung, non-Hodgkin’s lymphoma, and breast cancer survivors; (2) three-class solution in uterine and cervical cancer survivors; and (3) two-class solution in colorectal cancer survivors. Conclusion: Identifying symptom subgroups by cancer diagnosis has the potential to develop innovative and effective targeted interventions in cancer survivors. Further research is needed to establish extensive knowledge in symptom clustering between treatment regimens, and short-term and long-term cancer survivors.

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Addressing cancer-related fatigue through sleep: A secondary analysis of a randomized trial comparing acupuncture and cognitive behavioral therapy for insomnia

Cited by 5 publications

References 60 publications

Global Trends and Emerging Hotspots in Cancer-Related Fatigue: A Comprehensive Bibliometric and Visual Analysis in Nursing Research

Global Trends and Emerging Hotspots in Cancer-Related Fatigue: A Comprehensive Bibliometric and Visual Analysis in Nursing Research

Randomized Controlled Trial of Virtually Delivered Cognitive Behavioral Therapy for Insomnia to Address Perceived Cancer-Related Cognitive Impairment in Cancer Survivors

Comparing Symptom Clusters in Cancer Survivors by Cancer Diagnosis: A Latent Class Profile Analysis

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