AdditiveChem: A comprehensive bioinformatics knowledge-base for food additive chemicals

Zhang, Dachuan; Cheng, Xueling; Sun, Dandan; Ding, Shaozhen; Cai, Pengli; Yuan, Le; Tian, Yu; Tu, Weiping; Hu, Qian-Nan

doi:10.1016/j.foodchem.2019.125519

Cited by 24 publications

(22 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In this study, we focus on the optimization of the esterification and oxa-Michael addition steps. Even if MC is an already known ester, , not much is reported in the literature regarding alternative ways for its synthesis from crotonic acid, apart from the use of high loadings of H 2 SO 4 …”

Section: Resultsmentioning

confidence: 99%

“…27 In this study, we focus on the optimization of the esterification and oxa-Michael addition steps. Even if MC is an already known ester, 41,42 not much is reported in the literature regarding alternative ways for its synthesis from crotonic acid, apart from the use of high loadings of H 2 SO 4 . 43 Therefore, to facilitate the workup, two acidic heterogeneous catalysts were tested: Amberlyst 15-H, a commercial acidic resin, and a recyclable catalyst prepared from the char produced through pyrolysis and sulfonation of starch (C-SO 3 H) that we already described.…”

Section: Mass Of Wastes (G) Mass Of Products (G)mentioning

confidence: 99%

See 1 more Smart Citation

Chemical Recycling of Polyhydroxybutyrate (PHB) into Bio-Based Solvents and Their Use in a Circular PHB Extraction

Parodi

D’Ambrosio

Mazzocchetti

et al. 2021

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

Two novel protocols for the chemical valorization of polyhydroxybutyrate (PHB) were developed, aiming at the production of two bio-based molecules: methyl 3-hydroxybutyrate (MHB) and methyl 3-methoxybutyrate (MMB). Optimized reaction conditions were applied to pure PHB and PHB inclusions inside bacterial cells as starting materials. MHB was synthesized through a single-step catalytic methanolysis, while MMB was synthesized through a three-step process: thermolytic distillation to give crotonic acid (CA), esterification to give methyl crotonate (MC), and oxa-Michael addition of MeOH. The obtained MHB and MMB were tested as solvents for the recovery of PHB itself both from freeze-dried single strain cultures (SSC) and mixed microbial cultures (MMC) with low to medium contents of PHB (22–57 wt %). High PHB recovery was achieved: up to 96 ± 1% through MHB and up to 98 ± 1% through MMB. Extraction from MMC slurry (with a PHB content of 39% on dry weight) was also performed, recovering 77 ± 2% using MHB and 92 ± 2% using MMB. High purities and excellent molecular weights and polydispersity indexes of extracted PHB were obtained with both MHB and MMB. Solubility in water, octanol/water partition coefficients (log K ow), and aerobic ready biodegradability of both solvents were also evaluated.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Mass Of Wastes (G) Mass Of Products (G)mentioning

confidence: 99%

Chemical Recycling of Polyhydroxybutyrate (PHB) into Bio-Based Solvents and Their Use in a Circular PHB Extraction

Parodi

D’Ambrosio

Mazzocchetti

et al. 2021

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…Metabolomics data are strongly related to the animal cellular processes as the end products, so it could be used to monitor the cattle health and product quality (61,62). The applications of bioinformatics are also beneficial for the research and development of new feed additives derived from natural products (63,64), and to help detect and suppress outbreaks of foodborne viruses to ensure food quality (63,64).…”

Section: Bioinformatics Serves As a Potential Tool In Determining Beementioning

confidence: 99%

Resveratrol stimulates microRNA expression during differentiation of bovine primary myoblasts

Hao

Wang

et al. 2021

Food & Nutrition Research

View full text Add to dashboard Cite

Background: Resveratrol (RSV), a phenolic compound, is present in many human dietary sources, such as peanuts, peanut butter, grapes skin, and grape wine. RSV has been widely known for its benefits on human health. Beef from cattle skeletal muscle is one of the main sources of protein for human consumption. Previous studies have also found that pork and chicken qualities are influenced by the feed supplementation with RSV. In addition, our previous study demonstrated the RSV effects on bovine myoblast differentiation using messenger RNA (mRNA) data. In this study, we mainly focused on the influences of RSV on microRNA (miRNA) expression. Method: We used 20 μM RSV to treat primary bovine myoblasts and extracted RNA for miRNA sequencing. After quality control and alignment for clean reads, we conducted quantification and analysis of differentially expressed (DE) miRNAs in the case (RSV-treated) group versus control (non-RSV treated) group. Next, we predicted the target genes for the DE miRNAs and analyzed them for the enrichments of Gene Ontology (GO) terms and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. Results: Finally, we identified 93 DE miRNAs (adjusted P-value < 0.05), of them 44 were upregulated and 49 were downregulated. Bta-miR-34c was the most significantly upregulated miRNA. In silico, prediction results indicated 1,869 target genes for the 93 DE miRNAs. GO enrichment analysis for the genes targeted by DE miRNAs revealed two significant GO terms (adjusted P-value < 0.05), in which the most significant one was stereocilium (GO:0032420). KEGG enrichment analysis showed five significant pathways, and the top significant KEGG pathway was the insulin signaling pathway (bta04910) (adjusted P-value < 0.05). Conclusions: This study provided an improved understanding of effects of RSV on primary bovine myoblast differentiation through the miRNA modulations. The results suggested that RSV could promote differentiation of primary bovine myoblast by stimulating the miRNA expressions. The target genes of DE miRNAs were significantly enriched in the insulin signaling pathway, thus potentially contributing to improving muscle leanness by increasing the energy metabolism.

show abstract

“…The synthetic counterparts present higher stability under the same conditions as well as higher colouring capacity and maintenance (Martins, Roriz, Morales, Barros, & Ferreira, 2016). Recent scientific studies have shown that artificial additives have several side effects and are often associated with toxicity problems (Zhang et al, 2020), such as hyperactivity and allergies (Kumar, Singh, Sharma, & Kishore, 2019). Aware of these evidences, the regulatory agencies, namely the European Food Safety Authority (EFSA) and the Food and Drug Administration of the United States of America (FDA) established several restrictions on the use of these additives (Carocho, Morales, & Ferreira, 2015).…”

Section: Introductionmentioning

confidence: 99%

Betacyanins from Gomphrena globosa L. flowers: Incorporation in cookies as natural colouring agents

et al. 2020

View full text Add to dashboard Cite

A betacyanin rich extract was obtained from the flowers of Gomphrena globosa L. by ultrasound-assisted extraction and dried either by lyophilization or spray-drying, was tested as a natural colourant in cookies and compared to a commercial colourant. The extracts were characterized in terms of betacyanin content and antioxidant potential. The effects of the colourants incorporation in the cookies were assessed through proximate composition, soluble sugars, fatty acids, color, texture and microbial load, over a shelf life of 30 days. Considering all the assays and analyzing the results through a 2-way analysis of variance, the cookies incorporated with spray-dried colourant showed the most intense pink coloration while cookies incorporated with lyophilized extract lost less color intensity over time. Thus, betacyanin extracts have potential as pink natural alternatives to synthetic colourants in the food industry.

show abstract

AdditiveChem: A comprehensive bioinformatics knowledge-base for food additive chemicals

Cited by 24 publications

References 23 publications

Chemical Recycling of Polyhydroxybutyrate (PHB) into Bio-Based Solvents and Their Use in a Circular PHB Extraction

Chemical Recycling of Polyhydroxybutyrate (PHB) into Bio-Based Solvents and Their Use in a Circular PHB Extraction

Resveratrol stimulates microRNA expression during differentiation of bovine primary myoblasts

Betacyanins from Gomphrena globosa L. flowers: Incorporation in cookies as natural colouring agents

Contact Info

Product

Resources

About