Additive preventive effect of influenza and pneumococcal vaccines in the elderly

Why Infants Rarely Die of COVID-19 and Morbidity and Mortality Rates Vary by Location: Pneumococcal and Hib Vaccinations as Possible Means to Mitigate Future Pandemics

“…If the resistance of infants and children to COVID-19 is due to these vaccinations, then the protection they provide is very significant. And notably, this vaccination strategy has already proven to be effective in mitigating influenza-associated complications and deaths (Mahamat, et al, 2013;Yang, et al, 2019) so that it will certainly have benefits in terms of decreasing morbidity and mortality associated with yearly influenza epidemics.…”

“…Second, vaccination of high-risk populations such as nursing home and retirement community residents, everyone over the age of 50, and all health-care workers, with Strep and Hib vaccines should significantly lower their risk of serious or fatal COVID-19 infections as it did previously did for influenzarelated deaths (Mahamat, et al, 2013;Yang, et al, 2019). Younger individuals may also benefit from these vaccinations in a time of constant threat of influenza and coronavirus pandemics although this recommendation currently runs counter to the guidelines in the US and most European nations (reviewed in Sing, 2017).…”

Influenza vaccines to control influenza-associated bacterial infection: where do we stand?

“…A similar study in France indicated there was no effect of the pneumococcal vaccine on influenza incidence, but there was a decrease in mortality after influenza infection, thus strongly suggesting there is an additive effect of dual vaccination. Moreover, this effect was higher when the influenza vaccine had a better match with the strains circulating that season [90]. It is important to add that the true benefit of influenza vaccine effectiveness in the elderly is being debated in the literature.…”

“…Case-control ‡18 41% (8-62) Spain [88] Cohort ‡65 9% (-8-23) France [90] Randomized control secondary analysis <2 45% (14-64) South Africa [100] Ecologic <5 Not included † Canada [98] Ecologic <2 Not included † Australia [99] Influenza vaccine studies measuring protection against secondary bacterial infections…”

Impfungen im Alter

“…Simultanimpfung gegen Pneumokokken und Influenza bei über 65-Jährigen bewiesen Für das Impfverhalten bei Senioren ist die Erkenntnis relevant, dass Mahamat et al [17] in einer Studie bei knapp 70.000 französischen Patienten ≥65 Jahren einen zusätzlichen Nutzen der Simultanimpfung gegen Pneumokokken und Influenza nachgewiesen haben. Die in der Studie simultan gegen Pneumokokken und Influenza Geimpften haben im Gegensatz zu denjenigen, die entweder nur gegen Influenza oder nur gegen Pneumokokken geimpft wurden, eine geringere 1-Jahres-"all-cause"-Mortalität gezeigt.…”