Additive manufacturing of polylactic acid-based nanofibers composites for innovative scaffolding applications

Kour, Khushwant; Kumar, Ranvijay; Singh, Gurpreet; Singh, Gurminder; Singh, Sunpreet; Sandhu, Kamalpreet

doi:10.1007/s12008-023-01435-0

Cited by 6 publications

(4 citation statements)

References 90 publications

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“…Electrospinning is an er-fiber fabrication method in which a high-voltage electric field is used to draw very fine fibers from a polymer solution or melt. When the electric field is strong enough to overcome the surface tension of the liquid, a charged jet is ejected, and embedded fiber membranes are deposited on the target collector [17][18][19]. The fabricated nanofibers have high surface area-to-volume ratios and porous, nonwoven morphologies that make them suitable for a variety of applications.…”

Section: Basics Of Electrospun Nanofiber Materialsmentioning

confidence: 99%

“…Additionally, the biodegradable nature of the materials reduces long-term toxicity issues. Furthermore, sourcing the materials from renewable sources improves the overall sustainability of producing the nanofibers [6,17,22]. Biomedical roles focus on regenerative applications like implants, scaffolds and wound care.…”

Section: Basics Of Electrospun Nanofiber Materialsmentioning

confidence: 99%

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Green Electrospun Nanofibers for Biomedicine and Biotechnology

Berdimurodov,

Dagdag,

Berdimuradov

et al. 2023

Technologies

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Green electrospinning harnesses the potential of renewable biomaterials to craft biodegradable nanofiber structures, expanding their utility across a spectrum of applications. In this comprehensive review, we summarize the production, characterization and application of electrospun cellulose, collagen, gelatin and other biopolymer nanofibers in tissue engineering, drug delivery, biosensing, environmental remediation, agriculture and synthetic biology. These applications span diverse fields, including tissue engineering, drug delivery, biosensing, environmental remediation, agriculture, and synthetic biology. In the realm of tissue engineering, nanofibers emerge as key players, adept at mimicking the intricacies of the extracellular matrix. These fibers serve as scaffolds and vascular grafts, showcasing their potential to regenerate and repair tissues. Moreover, they facilitate controlled drug and gene delivery, ensuring sustained therapeutic levels essential for optimized wound healing and cancer treatment. Biosensing platforms, another prominent arena, leverage nanofibers by immobilizing enzymes and antibodies onto their surfaces. This enables precise glucose monitoring, pathogen detection, and immunodiagnostics. In the environmental sector, these fibers prove invaluable, purifying water through efficient adsorption and filtration, while also serving as potent air filtration agents against pollutants and pathogens. Agricultural applications see the deployment of nanofibers in controlled release fertilizers and pesticides, enhancing crop management, and extending antimicrobial food packaging coatings to prolong shelf life. In the realm of synthetic biology, these fibers play a pivotal role by encapsulating cells and facilitating bacteria-mediated prodrug activation strategies. Across this multifaceted landscape, nanofibers offer tunable topographies and surface functionalities that tightly regulate cellular behavior and molecular interactions. Importantly, their biodegradable nature aligns with sustainability goals, positioning them as promising alternatives to synthetic polymer-based technologies. As research and development continue to refine and expand the capabilities of green electrospun nanofibers, their versatility promises to advance numerous applications in the realms of biomedicine and biotechnology, contributing to a more sustainable and environmentally conscious future.

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Section: Basics Of Electrospun Nanofiber Materialsmentioning

confidence: 99%

Section: Basics Of Electrospun Nanofiber Materialsmentioning

confidence: 99%

Green Electrospun Nanofibers for Biomedicine and Biotechnology

Berdimurodov,

Dagdag,

Berdimuradov

et al. 2023

Technologies

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“…Polylactic acid (PLA), due to its physio-chemical and biological properties, is the composite matrix of choice. PLA possesses good physical and mechanical properties [11][12][13], bioresorbable properties [14][15][16][17][18], degradability [19][20][21][22][23], cell compatibility [24,25] and exhibits biological activity in its biocomposites [26][27][28][29][30][31][32]. PLA is not toxic [33,34], has hemostatic ability [35][36][37][38][39][40] and, although it does not have inherent antibacterial properties, it presents synergistic biocidal and anti-bacterial adhesion properties [41][42][43].…”

Section: Introductionmentioning

confidence: 99%

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Mrozińska,

Ponczek,

Kaczmarek

et al. 2024

Coatings

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This article presents the biochemical properties of poly(lactide)-zinc (PLA-Zn) composites obtained by DC magnetron sputtering of zinc onto melt-blown nonwoven fabrics. The biochemical properties were determined by the evaluation of the activated partial thromboplastin time (aPTT) and prothrombin time (PT). The antimicrobial activity of the PLA-Zn samples was additionally tested against representative Gram-positive and Gram-negative bacteria strains. A structural study of the PLA-Zn has been carried out using specific surface area and total pore volume (BET) analysis, as well as atomic absorption spectrometry with flame excitation (FAAS). PLA-Zn composites exhibited an antibacterial effect against the analyzed strains and produced inhibition zones against E. coli and S. aureus. Biochemical investigations revealed that the untreated PLA fibers caused the acceleration of the clotting of human blood plasma in the intrinsic pathway. However, the PLA-Zn composites demonstrated significantly different properties in this regard, the aPTT was prolonged while the PT was not altered.

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“…[ 23–25 ] Over the years, polymer‐based organic materials have shown tremendous scope in various applications like soft robotics, sensors, and digital technology. [ 26–29 ] However, these polymers have shown reluctance to environmental stimuli due to the presence of irreversible covalent bonds. Thus, these polymers require the fine‐tuning of their intrinsic properties through external stimulations for biocomputing, artificial machines, and therapeutic applications.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

Tariq,

Arif,

Khalid

et al. 2023

Adv Eng Mater

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Stimuli‐responsive polymers (SRPs) are special types of soft materials, which have been extensively used for developing flexible actuators, soft robots, wearable devices, sensors, self‐expanding structures, and biomedical devices, thanks to their ability to change their shapes and functional properties in response to external stimuli including light, humidity, heat, pH, electric field, solvent, and magnetic field or combinations of two or more of these stimuli. In recent years, additive manufacturing (AM) aka three‐dimensional (3D) printing technology of these SRPs, also known as four‐dimensional (4D) printing, has gained phenomenal attention in different engineering fields, thanks to its unique ability to develop complex, personalized, and innovative structures, which undergo twisting, elongating, swelling, rolling, shrinking, bending, spiraling, and other complex morphological transformations. Herein, an effort has been made to provide insightful information about the AM techniques, type of SRPs, and their applications including, but not limited to tissue engineering, soft robots, bionics, actuators, sensors, construction, and smart textiles. This article also incorporates the current challenges and prospects, hoping to provide an insightful basis for the utilization of this technology in different engineering fields. It is expected that the amalgamation of 3D printing with SRPs would provide unparalleled advantages in different engineering arenas.This article is protected by copyright. All rights reserved.

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Additive manufacturing of polylactic acid-based nanofibers composites for innovative scaffolding applications

Cited by 6 publications

References 90 publications

Green Electrospun Nanofibers for Biomedicine and Biotechnology

Green Electrospun Nanofibers for Biomedicine and Biotechnology

Activity in the Field of Blood Coagulation Processes of Poly(Lactide)-Zinc Fiber Composite Material Obtained by Magnetron Sputtering

Recent Advances in the Additive Manufacturing of Stimuli‐Responsive Soft Polymers

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