Additive manufacturing of biodegradable magnesium implants and scaffolds: Review of the recent advances and research trends

Sezer, Nurettin; Evis, Zafer; Koç, Muammer

doi:10.1016/j.jma.2020.09.014

Cited by 111 publications

(61 citation statements)

References 136 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Z (Zinc), W (Yttrium), T (Tin), S (Silicon), R (Chromium), O (Silver), N (Nickel), M (Manganese), L (Lithium), K (Zirconium), H (Thorium), F (Iron), E (Rare earth metals), D (Cadmium), C (Copper), B (Bismuth), and A (Aluminum) are the prefix letters for two main alloying metals in Mg composites formed based on ASTM B275. [20].…”

Section: Application Of Biodegradable Mg Alloys In Orthopedic Implantsmentioning

confidence: 99%

“…The first category contains between 2 and 10% wt% Al with a small amount of Zn and Mn, showing increased tolerance and mechanics. The second group is the combination of scarce earth elements and another metal including Ag, Zn, Y, and a lesser amount of Zr, leading to improved degradation resistance, finer grain structure, and mechanical performance [20]. Most researches showed that alloying is an appropriate method to control the Mg degradation rate but it does not influence its fundamental qualities.…”

Section: Application Of Biodegradable Mg Alloys In Orthopedic Implantsmentioning

confidence: 99%

See 1 more Smart Citation

A review of additive manufacturing of Mg-based alloys and composite implants

Zamani

Ghazanfari

Erabi

et al. 2021

jcc

View full text Add to dashboard Cite

Magnesium based materials are considered promising biodegradable metals for orthopedic bone implant applications as they exhibit similar density and elastic modulus to that of bone, biodegradability, and excellent osteogenic properties. The use of Mg based biomaterials eliminates the limitations of currently used implant materials such as stress shielding and the need for the second surgery. Recently, the development of Mg-based implants has attracted significant attention. Additive manufacturing is one of the effective techniques to develop Mg based implants. Additive manufacturing which could be named 3D printing is a transformative and rapid method of producing industrial parts with in the acceptable dimensional range. Therefore, recent investigations have tried to apply this method for the development of Mg-based implants. This state-of-the-art review focuses on the additive manufacturing of Mg biodegradable materials and their in-vitro corrosion and degradation, and mechanical properties. The future directions to develop Mg biodegradable materials are reported through summarization of current achievements.

show abstract

Section: Application Of Biodegradable Mg Alloys In Orthopedic Implantsmentioning

confidence: 99%

Section: Application Of Biodegradable Mg Alloys In Orthopedic Implantsmentioning

confidence: 99%

A review of additive manufacturing of Mg-based alloys and composite implants

Zamani

Ghazanfari

Erabi

et al. 2021

jcc

View full text Add to dashboard Cite

show abstract

“…Furthermore, the by-products from the corrosion are retained in the body for a long time in biological matrices and healed from the body at a low rate [4]. As a result, Fe is unsuitable for use in biomedical applications unless its corrosion rate is modified [8]. However, the degradation rate of zinc is between magnesium and iron; it is lower than Mg and higher than Fe [5].…”

Section: Introductionmentioning

confidence: 99%

“…As a result, Zn has recently received a lot of attention. Nonetheless, its low strength and ductility limit its use in load-bearing applications [8]. In addition, a high release of pure Zn more than 100-300 mg/day leads to health issues [9].…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

et al. 2021

View full text Add to dashboard Cite

The development of biodegradable implants is certainly intriguing, and magnesium and its alloys are considered significant among the various biodegradable materials. Nevertheless, the fast degradation, the generation of a significant amount of hydrogen gas, and the escalation in the pH value of the body solution are significant barriers to their use as an implant material. The appropriate approach is able to solve this issue, resulting in a decrease the rate of Mg degradation, which can be accomplished by alloying, surface adjustment, and mechanical treatment. Surface modification is a practical option because it not only improves corrosion resistance but also prepares a treated surface to improve bone regeneration and cell attachment. Metal coatings, ceramic coatings, and permanent polymers were shown to minimize degradation rates, but inflammation and foreign body responses were also suggested. In contrast to permanent materials, the bioabsorbable polymers normally show the desired biocompatibility. In order to improve the performance of drugs, they are generally encapsulated in biodegradable polymers. This study summarized the most recent advancements in manufacturing polymeric coatings on Mg alloys. The related corrosion resistance enhancement strategies and future potentials are discussed. Ultimately, the major challenges and difficulties are presented with aim of the development of polymer-coated Mg-based implant materials.

show abstract

“…Unfortunately, pure Magnesium is not directly suitable for such applications due to its insufficient mechanical and corrosion properties. Magnesium alloys have been than considered since overcoming most of these difficulties [8,[10][11][12][13][14][15][16]. However, not all of them could be considered as proper materials for the resorbable medical implants especially when containing high concentration of elements such as Zirconium, Aluminum, and rare earths metals that may induce inflammatory cascades and tissue damage [5,[15][16][17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

Bio-Resorption Control and Biological Response of Magnesium Alloy AZ31 Coated with Poly-β-hydroxybutyrate

Wang¹,

Hou²,

Tian³

et al. 2021

Preprint

View full text Add to dashboard Cite

Magnesium and its alloys are not normally used as bio-resorbable temporary implants due to their high and uncontrolled degradation rate in physiological liquid environment. The improvement of corrosion resistance to simulated body fluids (SBF) of a Magnesium alloy (AZ31) coated with poly-β-hydroxybutyrate (PHB) was investigated. Scanning electron microscopy, Fourier transform infrared spectrometer, and contact angle measurements were used to characterize surface morphology, material composition and wettability, respectively. pH modification of the SBF corroding medium, mass of Mg2+ ions released, and weight loss of the samples exposed to the SBF solution, and electrochemical experiment were used to describe the corrosion process and its kinetics. Materials biocompatibility was described by evaluating the effect of corrosion by products collected in the SBF equilibrating solution on hemolysis ratio, cytotoxicity, Nitric Oxide (NO), and total antioxidant capacity (T-AOC). The results showed that the PHB coating can diffusively control the degradation rate of Magnesium alloy improving its biocompatibility: hemolysis rate of materials was lower than 5%, while in vitro Human Umbilical Vein Endothelial Cells（HUVECs) compatibility experiments showed that PHB coated Mg alloy promoted cell proliferation and had no effect on the NO content, the T-AOC was enhanced compared with the normal group and bare AZ31 alloy. PHB coated AZ31 Magnesium alloy extraction fluids have a less toxic behavior due to the lower concentration of corrosion by-products deriving from the diffusion control exerted by the PHB coating films both from metal surface to the solution and vice versa. These findings provide more reference value for the selection of such system as tunable bioresorbable prosthetic materials

show abstract

Additive manufacturing of biodegradable magnesium implants and scaffolds: Review of the recent advances and research trends

Cited by 111 publications

References 136 publications

A review of additive manufacturing of Mg-based alloys and composite implants

A review of additive manufacturing of Mg-based alloys and composite implants

A Comprehensive Review on Surface Modifications of Biodegradable Magnesium-Based Implant Alloy: Polymer Coatings Opportunities and Challenges

Bio-Resorption Control and Biological Response of Magnesium Alloy AZ31 Coated with Poly-β-hydroxybutyrate

Contact Info

Product

Resources

About