Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities

Tino, Rance; Leary, Martin; Yeo, Adam; Kyriakou, E.; Kron, Tomas; Brandt, Milan

doi:10.1088/2631-7990/ab70af

Cited by 58 publications

(44 citation statements)

References 150 publications

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“…For example, fixation approaches could be adapted based on those used in radiation therapy. 43 The pulsatile waveform shape (referred to here as the decorrelation temporal profile) should be further studied. To support this, comparisons to alternative methods, such as Doppler OCT or plethysmography, could be made.…”

Section: Discussionmentioning

confidence: 99%

Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

et al. 2020

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Significance: Pulsatility is a vital characteristic of the cardiovascular system. Characterization of the pulsatility pattern locally in the peripheral microvasculature is currently not readily available and would provide an additional source of information, which may prove important in understanding the pathophysiology of arterial stiffening, vascular ageing, and their linkage with cardiovascular disease development. Aim: We aim to confirm the suitability of speckle decorrelation optical coherence tomography angiography (OCTA) under various noncontact/contact scanning protocols for the visualization of pulsatility patterns in vessel-free tissue and in the microvasculature of peripheral human skin. Results: Results from five healthy subjects show distinct pulsatile patterns both in vessel-free tissue with either noncontact or contact imaging and in individual microvessels with contact imaging. Respectively, these patterns are likely caused by the pulsatile pressure and pulsatile blood flow. The pulse rates show good agreement with those from pulse oximetry, confirming that the pulsatile signatures reflect pulsatile hemodynamics. Conclusions: This study demonstrates the potential of speckle decorrelation OCTA for measuring localized peripheral cutaneous pulsatility and defines scanning protocols necessary to undertake such measurements. Noncontact imaging should be used for the study of pulsatility in vessel-free tissue and contact imaging with strong mechanical coupling in individual microvessels. Further studies of microcirculation based upon this method and protocols are warranted.

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Section: Discussionmentioning

confidence: 99%

Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

et al. 2020

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“…Nowadays, three-dimensional (3D) printing technology has been used in radiation oncology to fabricate personalized and customized treatment accessories such as bolus, brachytherapy applicators, immobilizers, and compensators. 12,13 Therefore, our proposed immobilization penis holder can be fabricated by 3D printing. Another radiotherapy approach that can be used to treat UC is brachytherapy.…”

Section: Discussionmentioning

confidence: 99%

Novel treatment setup for urethral carcinoma radiotherapy: A complete response case report

Molana

Rostami

Khajetash

et al. 2020

Clinical Case Reports

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This study offers a new treatment setup for external beam radiation therapy (EBRT) of the urethra carcinoma (UC) with reproducible supine technique obtained by homemade and personalized immobilization penis holder that at the same time, radiation dose to testicle can be reduced using testicular shield. Urethra carcinoma (UC) is a rare form of urological cancers with a poor prognosis. 1 In overall, UC makes up <1% of the total incidence of all malignant tumors. 2 Although this malignancy occurs in both men and women, the incidence of UC is approximately three times more in men than in women. As reported, the age-standardized rate (ASR) for UC is 1.6/million in men and 0.6/million in women. 3 Up to this date, owing to the rarity of UC, no prospective studies have been performed to determine the best treatment outcomes. Therefore, information about the treatment of UC and treatment outcomes is derived from retrospective studies or case series. As a consequence, an individualized treatment approach is adopted for this malignancy. The combination of radiation therapy and chemotherapy using 5-FU and Mitomycin-C has been reported for locally advanced UC. 4-6 In overall, the reproducibility of patient and target position between computed tomography (CT) planning and each treatment fraction is very important. 7-9 In radiotherapy for the male UC, treatment setup is considered as a main

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“…Additive manufacturing (AM), hailed as one of the most innovative technologies in Industry 4.0, is leading to innovations in a wide range of sectors, including aerospace, automotive, and medical 1 , 2 . However, the low repeatability of qualified parts prevents AM from being fully adopted in practical applications, especially in industries with strict requirements on parts quality 3 , 4 .…”

Section: Introductionmentioning

confidence: 99%

In-situ porosity recognition for laser additive manufacturing of 7075-Al alloy using plasma emission spectroscopy

Ren

Mazumder

2020

Sci Rep

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Poor quality and low repeatability of additively manufactured parts are key technological obstacles for the widespread adoption of additive manufacturing (AM). In-situ monitoring and control of the AM process is vital to overcome this problem. This paper describes the combined artificial intelligence and plasma emission spectroscopy to identify the porosity of AM parts during the process. The time- and position-synchronized spectra were collected during the directed energy deposition (DED) manufacturing process of a 7075-Al alloy part. Eighteen features extracted from spectra were coupled with the deposition qualities which were characterized by the 3D X-ray Computed Tomography (CT) scan and used to train a Random Forest (RF) classifier. The well-trained RF classifier achieved up to 83% precision for the porosity recognition of depositions. The feature importance recorded by the RF classifier indicates that the intensities of spectra at the wavelength of 414.234 (Fe I) nm and 396.054 (Al I) nm, and the kurtosis of spectra at wavelength ranges of 484–490 nm and 508–518 nm, are the most effective features for porosity recognition. The physical correlations between spectra, porosity formation, and thermal accumulation during the AM process were analyzed. This study demonstrates the great potentials, as well as challenges of plasma emission spectroscopy for in-situ quality monitoring of laser AM which allows the enhancement of AM technique.

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Additive manufacturing in radiation oncology: a review of clinical practice, emerging trends and research opportunities

Cited by 58 publications

References 150 publications

Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

Detection of localized pulsatile motion in cutaneous microcirculation by speckle decorrelation optical coherence tomography angiography

Novel treatment setup for urethral carcinoma radiotherapy: A complete response case report

In-situ porosity recognition for laser additive manufacturing of 7075-Al alloy using plasma emission spectroscopy

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