2022
DOI: 10.23876/j.krcp.21.111
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Additive harmful effects of acute kidney injury and acute heart failure on mortality in hospitalized patients

Abstract: Background: Organ crosstalk between the kidney and the heart has been suggested. Acute kidney injury (AKI) and acute heart failure (AHF) are well-known independent risk factors for mortality in hospitalized patients. This study aimed to investigate if these conditions have an additive effect on mortality in hospitalized patients, as this has not been explored in previous studies. Methods: We retrospectively reviewed the records of 101,804 hospitalized patients who visited two tertiary hospitals in the Republic… Show more

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Cited by 4 publications
(3 citation statements)
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“…Indeed, AKI is a robust independent predictor for both in-hospital and 1-year mortality for HF patients [1,3]. AKI is independently associated with a higher risk of cardiovascular events, especially recurrent HF, after hospital discharge [4][5][6][7]. This relationship is also associated with a higher likelihood of chronic kidney disease (CKD), expedited progression to end-stage renal disease, and a decline in health-related quality of life [2,8].…”
Section: Introductionmentioning
confidence: 99%
“…Indeed, AKI is a robust independent predictor for both in-hospital and 1-year mortality for HF patients [1,3]. AKI is independently associated with a higher risk of cardiovascular events, especially recurrent HF, after hospital discharge [4][5][6][7]. This relationship is also associated with a higher likelihood of chronic kidney disease (CKD), expedited progression to end-stage renal disease, and a decline in health-related quality of life [2,8].…”
Section: Introductionmentioning
confidence: 99%
“…In patients with severe AKI requiring renal replacement therapy, the rate of in-hospital mortality has been reported to be 50% to 60% over the past two decades [2,3]. For those who survive, the AKI episode confers a risk of several complications, including progression to chronic kidney disease and subsequent events such as myocardial infarction and congestive heart failure [4][5][6][7][8].…”
Section: Introductionmentioning
confidence: 99%
“…Mortality stands as a cornerstone parameter in biomedical research [ 6 , 7 ]. Sometimes, addressing critical scientific inquiries becomes infeasible without knowledge of mortality rates.…”
mentioning
confidence: 99%