Additive Effects on Copper‐Catalyzed Tandem Reactions

Abstract

Introduction of a suitable additive to coppercatalyzed tandem reactions during heterocyclic synthesis is an efficient strategy. This short review mainly describes the results obtained over the period of January 2014 to December 2018 in the area of copper-catalyzed intramolecular tandem reactions to synthesize heterocyclic compounds.Five types of additives that can be used to improve reactivity and selectivity of these tandem reactions were highlighted. Particular attention is paid to demonstrate the importance of additives by comparing results obtained in its absence and presence, and the probable mechanistic role of the additive is discussed based on original articles. . Cu(MeCN) 4 PF 4 -catalyzed reaction of 1,n-enynes and α-carbonyl alkyl bromides. Scheme 33. Cu(OTf) 2 -catalyzed reaction of amino acids and 2-benzoylquinolines. Scheme 34. CuI-catalyzed reaction of o-iodoaniline derivatives S 8 and Ntosylhydrazone. 2 3 4 5 6 7 8

Synthesis and Antimicrobial Activity of the Pathogenic E. coli Strains of p-Quinols: Additive Effects of Copper-Catalyzed Addition of Aryl Boronic Acid to Benzoquinones

“…Additionally, the formation of side products hampered product purification. Therefore, the previously developed method is characterized by low atom economy [ 41 , 42 , 43 , 44 , 45 , 46 , 47 ].…”

1,10‐Phenanthroline: A versatile ligand to promote copper‐catalyzed cascade reactions

“…As illustrated in previous literature, [24][25][26][27] tandem reaction is a complex reaction process, and thus recognizing the detailed mechanistic role of [CuL] is not easy. The [CuL]-catalyzed step may initiate the whole reaction, [28] participate in the intermediate transformation or pull the last step to complete the whole reaction.…”