Additive effects of nutritional supplementation, together with isphosphonates, on bone mineral density after hip fracture: a 12-month randomized controlled study

Abstract

BackgroundAfter a hip fracture, a catabolic state develops, with increased bone loss during the first year. The aim of this study was to evaluate the effects of postoperative treatment with calcium, vitamin D, and bisphosphonates (alone or together) with nutritional supplementation on total hip and total body bone mineral density (BMD).MethodsSeventy-nine patients (56 women), with a mean age of 79 years (range, 61–96 years) and with a recent hip fracture, who were ambulatory before fracture and without severe cognitive impairment, were included. Patients were randomized to treatment with bisphosphonates (risedronate 35 mg weekly) for 12 months (B; n=28), treatment with bisphosphonates along with nutritional supplementation (40 g protein, 600 kcal daily) for the first 6 months (BN; n=26), or to controls (C; n=25). All participants received calcium (1,000 mg) and vitamin D3 (800 IU) daily. Total hip and total body BMD were assessed with dual-energy X-ray absorptiometry at baseline, 6, and 12 months. Marker of bone resorption C-terminal telopeptide of collagen I and 25-hydroxy vitamin D were analyzed in serum.ResultsAnalysis of complete cases (70/79 at 6 months and 67/79 at 12 months) showed an increase in total hip BMD of 0.7% in the BN group, whereas the B and C groups lost 1.1% and 2.4% of BMD, respectively, between baseline and 6 months (P=0.071, between groups). There was no change in total body BMD between baseline and 12 months in the BN group, whereas the B group and C group both lost BMD, with C losing more than B (P=0.009). Intention-to-treat analysis was in concordance with the complete cases analyses.ConclusionProtein-and energy-rich supplementation in addition to calcium, vitamin D, and bisphosphonate therapy had additive effects on total body BMD and total hip BMD among elderly hip fracture patients.

Dietary protein and bone health: a systematic review and meta-analysis from the National Osteoporosis Foundation,

“…Six of the 8 RCTs (26,31,(34)(35)(36)46) found no significant difference in the net changes in TH BMD over 1-2 y (Supplemental Table 7). Two RCTs (29,38) that administered dietary composition changes found that the lower-protein groups lost significantly more or gained significantly less TH BMD than the higher-protein groups after 1 y (Supplemental Table 7).…”

“…Two studies (25,46) Table 6). Overall, ROB was medium, primarily due to low compliance (,80%) and incomplete outcome data (dropout rate .20%) (Supplemental Figure 1, Supplemental Table 4).…”

“…Overall, ROB was medium, primarily due to low compliance (,80%) and incomplete outcome data (dropout rate .20%) (Supplemental Figure 1, Supplemental Table 4). Findings from the 5 RCTs were inconsistent: 2 RCTs (25, 29) found that the lower-protein groups lost significantly more TB BMD than did the higher-protein groups after 1 y; 3 RCTs (38,46,47) found no significant difference in the net changes in TB BMD after 1 y (Supplemental Table 7). Data were not sufficient to conduct a meta-analysis.…”

“…Five RCTs examined CTX concentrations (25,28,34,35,46) (Supplemental Table 6). Four studies (25,28,35,46) prescribed supplements.…”

“…Four studies (25,28,35,46) prescribed supplements. The doses of milk-based protein in the higherprotein groups ranged from 10 to 45 g/d, whereas the lowerprotein groups received 0 g protein/d.…”