Additive Effect of the Combination of Griseofulvin and Ketoconazole Against <i>Microsporum canis</i> in Vitro: Additiver Effekt der Kombination von Griseofulvin und Ketoconazol gegen <i>Microsporum canis</i> in vitro

Banic, S; Lunder, Majda

doi:10.1111/j.1439-0507.1989.tb02288.x

Cited by 4 publications

(3 citation statements)

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“…and E. floccosum. Combinations included amorolfine plus azoles or terbinafine or griseofulvin; azoles plus griseofulvin or terbinafine; azoles plus ciclopirox [24][25][26][27][28][29][30]. Checkerboard titration methodology was the most common procedure for testing a combination (6/7 studies).…”

Section: Antifungal Combinationsmentioning

confidence: 99%

Antifungal Combinations in Dermatophytes

Brescini

Fioriti

Morroni

et al. 2021

JoF

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Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. Therefore, we reviewed the scientific literature concerning the antifungal combinations against dermatophytes. A literature search on the subject performed in PubMed yielded 68 publications: 37 articles referring to in vitro studies and 31 articles referring to case reports or clinical studies. In vitro studies involved over 400 clinical isolates of dermatophytes (69% Trichophyton spp., 29% Microsporum spp., and 2% Epidermophyton floccosum). Combinations included two antifungal agents or an antifungal agent plus another chemical compound including plant extracts or essential oils, calcineurin inhibitors, peptides, disinfectant agents, and others. In general, drug combinations yielded variable results spanning from synergism to indifference. Antagonism was rarely seen. In over 700 patients with documented dermatophyte infections, an antifungal combination approach could be evaluated. The most frequent combination included a systemic antifungal agent administered orally (i.e., terbinafine, griseofulvin, or azole—mainly itraconazole) plus a topical medication (i.e., azole, terbinafine, ciclopirox, amorolfine) for several weeks. Clinical results indicate that association of antifungal agents is effective, and it might be useful to accelerate the clinical and microbiological healing of a superficial infection. Antifungal combinations in dermatophytes have gained considerable scientific interest over the years and, in consideration of the interesting results available so far, it is desirable to continue the research in this field.

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Section: Antifungal Combinationsmentioning

confidence: 99%

Antifungal Combinations in Dermatophytes

Brescini

Fioriti

Morroni

et al. 2021

JoF

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show abstract

“…and E. floccosum. Combination included: amorolfine plus azoles or terbinafine or griseofulvin; azoles plus griseofulvin or terbinafine; azoles plus ciclopirox [24][25][26][27][28][29][30]. Checkerboard titration methodology was the most common procedure for testing the combination (6/7 studies).…”

Section: Antifungal Combinationsmentioning

confidence: 99%

Antifungal Combinations in Dermatophytes

Brescini¹,

Fioriti²,

Morroni³

et al. 2021

Preprint

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Dermatophytes are the most common cause of fungal infections worldwide, affecting millions of people annually. The emergence of resistance among dermatophytes along with the availability of antifungal susceptibility procedures suitable for testing antifungal agents against this group of fungi make the combinatorial approach particularly interesting to be investigated. Therefore, we reviewed the scientific literature concerning the antifungal combinations in dermatophytes. A literature search on the subject performed in PubMed yielded 68 publications: 37 articles referring to in vitro studies, and 31 articles referring to case reports/clinical studies. In vitro studies involved over 400 clinical isolates of dermatophytes (69% Trichophyton spp., 29% Microsporum spp., and 2% Epidermophyton floccosum). Combinations included two antifungal agents or an antifungal agent plus another chemical compound including plant extracts/essential oils, calcineurin inhibitors, peptides, disinfectant agents and others. In general, drug combinations yielded variable results spanning from synergism to indifference. Antagonism was rarely seen. In over 700 patients with documented dermatophyte infections an antifungal combination approach could be evaluated. The most frequent combination included a systemic antifungal agent administered orally (i.e.: azole [mainly itraconazole], terbinafine or griseofulvin) plus a topical medication (i.e.: azole, terbinafine, ciclopirox, amorolfine) for several weeks. Clinical results indicate that association of antifungal agents is effective, and it might be useful in accelerate the clinical and microbiological healing of a superficial infection. Antifungal combinations in dermatophytes have gained considerable scientific interest over the years and, in consideration of the interesting results available as far, it is desirable to continue the research in this field.

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“…Griseofulvin, a chlorine-containing secondary metabolite first isolated from Penicillium griseofulvin, is considered an effective antifungal agent and is widely used in dermatophyte treatment [6,7]. In fungi, griseofulvin replaces the structurally similar guanine and binds to DNA, then interferes with DNA biosynthesis and finally inhibits the mitotic process and fungal growth [8]. In addition, griseofulvin is an effective anti-cancer agent.…”

Section: Introductionmentioning

confidence: 99%

Griseofulvin Inhibits Root Growth by Targeting Microtubule-Associated Proteins Rather Tubulins in Arabidopsis

Guo

Shi

et al. 2023

IJMS

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Griseofulvin was considered an effective agent for cancer therapy in past decades. Although the negative effects of griseofulvin on microtubule stability are known, the exact target and mechanism of action in plants remain unclear. Here, we used trifluralin, a well-known herbicide targeting microtubules, as a reference and revealed the differences in root tip morphology, reactive oxygen species production (ROS), microtubule dynamics, and transcriptome analysis between Arabidopsis treated with griseofulvin and trifluralin to elucidate the mechanism of root growth inhibition by griseofulvin. Like trifluralin, griseofulvin inhibited root growth and caused significant swelling of the root tip due to cell death induced by ROS. However, the presence of griseofulvin and trifluralin caused cell swelling in the transition zone (TZ) and meristematic zone (MZ) of root tips, respectively. Further observations revealed that griseofulvin first destroyed cortical microtubules in the cells of the TZ and early elongation zone (EZ) and then gradually affected the cells of other zones. The first target of trifluralin is the microtubules in the root MZ cells. Transcriptome analysis showed that griseofulvin mainly affected the expression of microtubule-associated protein (MAP) genes rather than tubulin genes, whereas trifluralin significantly suppressed the expression of αβ-tubulin genes. Finally, it was proposed that griseofulvin could first reduce the expression of MAP genes, meanwhile increasing the expression of auxin and ethylene-related genes to disrupt microtubule alignment in root tip TZ and early EZ cells, induce dramatic ROS production, and cause severe cell death, eventually leading to cell swelling in the corresponding zones and inhibition of root growth.

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Additive Effect of the Combination of Griseofulvin and Ketoconazole Against Microsporum canis in Vitro: Additiver Effekt der Kombination von Griseofulvin und Ketoconazol gegen Microsporum canis in vitro

Cited by 4 publications

References 0 publications

Antifungal Combinations in Dermatophytes

Antifungal Combinations in Dermatophytes

Antifungal Combinations in Dermatophytes

Griseofulvin Inhibits Root Growth by Targeting Microtubule-Associated Proteins Rather Tubulins in Arabidopsis

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