Additions to the Genus <em>Helicosporium </em>(Tubeufiaceae, Tubeufiales) from China with an Identification Key to <em>Helicosporium </em>Taxa

Abstract

Helicosporous hyphomycetes is a class of filamentous fungi that shows promising application prospects in metabolizing bioactive natural compounds. During a study of helicosporous fungi in China, six new helicosporous taxa were collected and isolated from decaying wood in Guangxi Zhuang Autonomous Region, China. Morphological comparisons with multi-gene phylogenetic analyses revealed that these six taxa belong to Helicosporium (Tubeufiaceae, Tubeufiales), and they can be recognized as three novel species, named Helicosporium liuzhouense, H. multidentatum and H. nanningense. Detailed descriptions and illustrations of the newly discovered taxa and comparisons with similar fungi are provided. In addition, a list and a key to accepted Helicosporium species are provided.

Polyketides from Neohelicosporium griseum: structure assignment and bioactivity investigation

“…The ethyl acetate extract was evaporated by rotation to obtain a crude extract of 150.3 g. The extract was separated by silica gel using a gradient elution of PE-EtOAc, yielding nine fractions (Fr. [1][2][3][4][5][6][7][8][9]. Crystallization occurred while sample Fr.4 was being placed in methylene chloride-methanol, yielding compound 1 (36.0 mg).…”

“…Helicosporous hyphomycetes are a group of saprophytic fungi characterized by helicoid conidia. In the past, researchers have paid more attention to their morphology and phylogeny [4][5]. However, these fungi can also produce secondary metabolites with novel structures and signi cant biological activity, especially in terms of anti-tumour activity [6][7].…”

“…In our search for fungal metabolites with promising bioactivities, we conducted a chemical investigation of the rice fermentation process involving the saprophytic fungus Neohelicosporium griseum GZCC 23-0142, which yielded eight polyketides (1)(2)(3)(4)(5)(6)(7)(8). This study examines the biological activities of these fungal metabolites, including their antimicrobial properties and in vitro cytotoxicity.…”

“…5 was further separated with Sephadex LH-20 in MeOH, producing ve subfractions (Fr.5.1-5.5). The methanol-dissolved portion of Fr.5.3 was puri ed by Semi-preparative HPLC eluting with MeOH-H 2 O (55:45), affording compound 5 (t R = 29.4 min, 43.3 mg).…”