Additions and Corrections - Structure-Activity Relationship Studies with Symmetric Naphthalenesulfonic Acid Derivatives. Synthesis and Influence of Spacer and Naphthalenesulfonic Acid Moiety on Anti-HIV-1 Activity.

Mohan, P. Maruthi; Wong, Man Fai; Verma, Sandeep; Huang, Peggy; Wickramasinghe, Anura; Baba, Masamori

doi:10.1021/jm00077a601

Cited by 2 publications

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“…Further screening of CSB analogues resulted in the identification of compounds such as 23 – 25 (Scheme ), in which the biphenyl core was replaced with stilbene to avoid degradation 101. Compounds 23 (quinobene) and 24 (resobene) showed moderate disruption of the gp120–CD4 interaction with IC 50 values of 1.3 μ M and 1.4 μ m, respectively, whereas 25 was markedly less potent (IC 50 =31 μ M ).…”

Section: Synthetic Modulators Of Protein–protein Interactions Frommentioning

confidence: 99%

Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

2005

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The development of small-molecule modulators of protein-protein interactions is a formidable goal, albeit one that possesses significant potential for the discovery of novel therapeutics. Despite the daunting challenges, a variety of examples exists for the inhibition of two large protein partners with low-molecular-weight ligands. This review discusses the strategies for targeting protein-protein interactions and the state of the art in the rational design of molecules that mimic the structures and functions of their natural targets.

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Section: Synthetic Modulators Of Protein–protein Interactions Frommentioning

confidence: 99%

Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

2005

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“…Ein weiteres Screening von CSB‐Analoga lieferte Verbindungen wie 23 – 25 (Schema ), bei denen die zentrale Biphenylgruppe durch Stilben ersetzt ist, um einen Molekülabbau zu vermeiden 101. Die Verbindungen 23 (Chinoben) und 24 (Resoben) unterbrechen die gp120‐CD4‐Bindung mit moderaten IC 50 ‐Werten von 1.3 μ M und 1.4 μ M , während 25 deutlich weniger wirksam ist (IC 50 =31 μ M ).…”

Section: Synthetische Modulatoren Von Protein‐protein‐wechselwirkuunclassified

Strategien zur Modulation von Protein‐Protein‐Wechselwirkungen mit synthetischen Substanzen

Yin

Hamilton

2005

Angewandte Chemie

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Die Entwicklung niedermolekularer Modulatoren von Protein‐Protein‐Wechselwirkungen gilt als wichtiges Forschungsziel mit großem Potenzial für die Entdeckung neuer Therapeutika. Trotz anspruchsvoller Voraussetzungen gibt es eine Reihe von Beispielen für die Inhibierung der Wechselwirkung großer Proteinbindungspartner durch einen niedermolekularen Liganden. In diesem Aufsatz geben wir einen Überblick über die Strategien zur Modulierung von Protein‐Protein‐Wechselwirkungen und präsentieren den aktuellen Forschungsstand beim rationalen Design von Mimetika, die die Strukturen und Funktionen ihrer natürlichen Zielstrukturen abbilden.

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Additions and Corrections - Structure-Activity Relationship Studies with Symmetric Naphthalenesulfonic Acid Derivatives. Synthesis and Influence of Spacer and Naphthalenesulfonic Acid Moiety on Anti-HIV-1 Activity.

Cited by 2 publications

References 0 publications

Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

Strategies for Targeting Protein–Protein Interactions With Synthetic Agents

Strategien zur Modulation von Protein‐Protein‐Wechselwirkungen mit synthetischen Substanzen

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