Additional value of tau protein measurement in the diagnosis of Creutzfeldt-Jakob disease

Cseh, Edina Katalin; Veres, Gábor; Danics, Krisztina; Szalárdy, Levente; Nánási, Nikolett; Klivényi, Péter; Vécsei, László; Zádori, Dénes

doi:10.18071/isz.72.0039

Cited by 2 publications

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“…Our biological function analyses showed that immune/CJD‐related genes were enriched in pathways associated with infection and the immune response. In recent years, an increasing number of epidemiological and experimental studies have shown that persistent infection in the brain can lead to protein misfolding and aggregation, resulting in oxidative stress injury, abnormal autophagy, apoptosis, and programmed necrosis, ultimately leading to neuronal damage and promoting the development of neurodegenerative diseases [27–33]. Continuous infection and abnormal protein deposition may lead to severe microglial activation.…”

Section: Discussionmentioning

confidence: 99%

Construction of immune/Creutzfeldt–Jakob disease‐related gene coexpression network to predict biomarkers

Xiaoou

Zhou

Liu

2021

Euro J of Neurology

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Background and purpose Creutzfeldt–Jakob disease (CJD) is a transmissible spongiform encephalopathy characterized by rapid onset and high mortality. Despite considerable progress in the treatment and diagnosis of CJD, patient prognosis remains poor. Many studies have found that the immune response is associated with the pathophysiology of CJD. However, few studies have reported coexpression correlations between genes associated with CJD and the immune response. This study was undertaken to construct a network of coexpressed immune‐ and CJD‐related genes that may reveal new biomarkers and therapeutic targets for CJD. Methods Gene expression data from 11 CJD patients and 10 nonneurological controls were obtained from the Gene Expression Omnibus database. High‐confidence protein–protein interaction (PPI) data were downloaded from the Human Protein Reference Database, and gene expression data of immune‐ and CJD‐associated genes were downloaded from the AmiGo16 and DisGeNET databases, respectively. An immune/CJD‐related expression network was constructed based on Pearson correlation coefficients and PPI networks, and a CJD‐directed neighbour coexpression network was extracted, in which we compared the gene expression patterns and correlations between different groups. The samples were classified using CJD‐specific modules, and differentially expressed genes (DEGs) between the CJD and nonneurological controls groups were identified within the CJD‐specific modules. Further functional analysis was performed using Kyoto Encyclopaedia of Genes and Genomes (KEGG) enrichment analysis of genes in each CJD‐specific module. Results We constructed an immune/CJD‐related coexpression gene network comprising 2007 nodes and 5268 edges, with immune‐associated genes occupying important positions in the network. In the CJD‐directed neighbour coexpression network, immune‐associated genes exhibited the highest coexpression level with their interacting genes. Results from Pearson correlation analysis showed that most of the CJD‐associated genes were positively correlated with immune‐associated genes. Screening for CJD‐specific modules identified MAPK1, CASP3, APP, MAPT, SNCA, and YWHAH, indicating a close connection between CJD and the immune response. Analyses of coexpression status and expression level of CJD‐specific genes revealed a very high coexpression pattern for any two genes, with most genes being DEGs. Finally, KEGG enrichment analyses of all CJD‐specific genes showed that the pathophysiology of CJD is closely related to infection and the immune response. Conclusions Our coexpression network analysis revealed a close connection between CJD‐ and immune‐associated genes, and we identified six CJD‐specific modules. Biological function analysis of CJD‐specific module genes revealed that immune responses are associated with CJD pathophysiology and may provide novel diagnostic and therapeutic biomarkers for this disease.

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Section: Discussionmentioning

confidence: 99%

Construction of immune/Creutzfeldt–Jakob disease‐related gene coexpression network to predict biomarkers

Xiaoou

Zhou

Liu

2021

Euro J of Neurology

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Exploring the Potential of Biomarkers for Early Diagnosis and Management of Sporadic Creutzfeldt - Jakob disease; A Review

Aderinto,

Olatunji

2023

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Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare and fatal neurodegenerative disorder with no known cure. Early diagnosis of sCJD is crucial for appropriate patient management, but currently, there is no single definitive diagnostic test. However, recent research has shown promising results in identifying novel biomarkers that may aid in the early diagnosis and management of sCJD. This review summarises the current state of biomarker research for sCJD, focusing on the potential of various biomarkers, including cerebrospinal fluid (CSF) biomarkers, neuroimaging techniques, and other potential biomarkers such as blood, urine, and saliva. Using these biomarkers has significantly improved the premortem diagnosis of sCJD, providing patients with valuable information about their condition and enabling them to make necessary plans for the future. Additionally, biomarkers have contributed to our understanding of the disease, paving the way for future therapies and management strategies. While biomarker research for sCJD has shown promising results, there are still several challenges and limitations that need to be addressed. Future research directions include the development of more sensitive and specific biomarkers, the standardisation of diagnostic criteria, and the validation of biomarkers across different patient populations.

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Additional value of tau protein measurement in the diagnosis of Creutzfeldt-Jakob disease

Abstract: A neutrophil-lymphocyta és a thrombocyta-lymphocvta arány értékelése esszenciális tremorban (English) Ali Zeynel Abidin Так, Yildizhan $engül A tau fehérje meghatározás kiegészítő szerepe a Creutzfeldt-Jakob-betegség diagnosztikájában (English)

Cited by 2 publications

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Construction of immune/Creutzfeldt–Jakob disease‐related gene coexpression network to predict biomarkers

Construction of immune/Creutzfeldt–Jakob disease‐related gene coexpression network to predict biomarkers

Exploring the Potential of Biomarkers for Early Diagnosis and Management of Sporadic Creutzfeldt - Jakob disease; A Review

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