Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature and related correspondence. A plea to assess oranges only

Paladini, D.

doi:10.1002/uog.14830

Cited by 6 publications

(6 citation statements)

References 8 publications

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“…Our concordance is lower than the review average. However, heterogeneity of factors such as sample size, patient selection, operator expertise and gestation at MRI in the review's individual studies does make direct extrapolation of results problematic. Overall, though, our local results are broadly comparable with the international review, where (as in our setting) scans were performed by fetal medicine experts in referral centres, and MRI use in selected cases provided helpful additional information .…”

Section: Discussionsupporting

confidence: 53%

Utility of fetal MRI for workup of fetal central nervous system anomalies in an Australian maternal-fetal medicine cohort

Irwin

Henry

Gopikrishna

et al. 2016

Aust N Z J Obstet Gynaecol

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Section: Discussionsupporting

confidence: 53%

Utility of fetal MRI for workup of fetal central nervous system anomalies in an Australian maternal-fetal medicine cohort

Irwin

Henry

Gopikrishna

et al. 2016

Aust N Z J Obstet Gynaecol

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“…We believe that these results represent a first attempt at separating apples from oranges. Until now, there has been a significant overestimation of the clinical usefulness of MRI in fetal brain anomalies, due to a worrying underperformance of what has been labelled ‘Level‐II’ ultrasound but which was apparently inferior even to screening level in some studies.…”

Section: Introductionmentioning

confidence: 81%

Indications for MRI in fetal isolated mild ventriculomegaly… ‘And then, there were none’

Paladini

Donarini

Rossi

2019

Ultrasound in Obstet & Gyne

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“…[ 19 ] In alobar HPE, the diagnosis can be made by ultrasonography, but a fetal MRI can be requested by a neurosonographer for a second-level examination if deemed necessary to identify other cerebral anomalies. [ 20 ]…”

Section: Discussionmentioning

confidence: 99%

Alobar holoprosencephaly associated with a rare chromosomal abnormality

et al. 2018

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Rationale:Holoprosencephaly is a structural malformation of the brain that results from the complete or incomplete noncleavage of the forebrain of the embryo into 2 hemispheres. We report a severe case of alobar holoprosencephaly diagnosed at 38 weeks, associated with cebocephaly, microcephaly, and craniosynostosis.Patient concern:The main knowledge added by this case is the late ultrasound diagnosis and chromosomal analysis that revealed a very rare abnormality (45X/46,XX/47,XX) with mosaicism at chromosome 18.Diagnoses:Investigation of the mother revealed nothing remarkable from clinical point of view and on laboratory tests. Ultrasonography identified a fetal biometry appropriate for gestational age, except for the head biometry and abdominal circumference, that were appropriate for less than the fifth percentile. Microcephaly, a large midline monoventricle, absent midlinestructures, cleft lip, cebocephaly (hypotelorism, single-nostril nose), ethmocephaly (hypotelorism, interorbital proboscis) and craniosynostosis, were also present. Fetal magnetic resonance imaging of fetus revealed an absent midline structure, a central monoventricle, abnormal corpus calosum, and abnormal gyri.Interventions:A cesarean section at 38 weeks was indicated for fetal bradycardia and a female baby was delivered, with Apgar score 6, weight 2290g. After birth, the diagnosis of the fetus confirmed holoprosencephaly with facial anomalies and demonstrated repeated tonic-clonic seizure, severe respiratory failure, cyanosis, decreased muscle tone, palor, and apnea. Laboratory examination of the newborn revealed acidosis and a prolonged of prothrombin time. The neonate was treated for severe respiratory distress syndrome, with immediate intubation and resuscitation. Vitamin K, fresh frozen plasma, and antibiotics were also administered.Outcomes:After delivery, exitus of the fetus occurred at 3 days and 18hours due to massive pulmonary hemorrhage.Lessons:We described a case of alobar holoprosencephaly diagnosed at 38 weeks of gestation and associated with a rare chromosomal abnormality (45X/46,XX/47,XX) with mosaicism at chromosome 18. Emotional implications could have been less severe if the patient underwent regular ultrasonography allowing a diagnosis in the first or early second trimester.

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Additional value of fetal magnetic resonance imaging in the prenatal diagnosis of central nervous system anomalies: a systematic review of the literature and related correspondence. A plea to assess oranges only

Cited by 6 publications

References 8 publications

Utility of fetal MRI for workup of fetal central nervous system anomalies in an Australian maternal-fetal medicine cohort

Utility of fetal MRI for workup of fetal central nervous system anomalies in an Australian maternal-fetal medicine cohort

Indications for MRI in fetal isolated mild ventriculomegaly… ‘And then, there were none’

Alobar holoprosencephaly associated with a rare chromosomal abnormality

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