Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse

Guglielmo, Marco; Arangalage, Dimitri; Bonino, Marco Augusto; Angelini, Gianmarco; Bonanni, Michela; Pascale, Patrizio; Leo, Laura Anna; Faletra, Francesco F.; Schwitter, Juerg; Pedrazzini, Giovanni; Monney, Pierre; Pavon, Anna Giulia

doi:10.1186/s12968-023-00944-x

Cited by 9 publications

(2 citation statements)

References 28 publications

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“… 26 Implementing T1-mapping and CMR feature tracking could reveal sub-clinical abnormalities in IVF patients with inferolateral MAD that might correlate with arrhythmias. 25 , 27 …”

Section: Discussionmentioning

confidence: 99%

Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?

Verheul,

Guglielmo,

Groeneveld

et al. 2024

European Heart Journal - Cardiovascular Imaging

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Aims Previously, we demonstrated that inferolateral mitral annular disjunction (MAD) is more prevalent in patients with idiopathic ventricular fibrillation (IVF) than in healthy controls. In the present study, we advanced the insights into the prevalence and ventricular arrhythmogenicity by inferolateral MAD in an even larger IVF cohort. Methods and results This retrospective multicentre study included 185 IVF patients (median age 39 [27, 52] years, 40% female). Cardiac magnetic resonance images were analysed for mitral valve and annular abnormalities and late gadolinium enhancement. Clinical characteristics were compared between patients with and without MAD. MAD in any of the 4 locations was present in 112 (61%) IVF patients and inferolateral MAD was identified in 24 (13%) IVF patients. Mitral valve prolapse (MVP) was found in 13 (7%) IVF patients. MVP was more prevalent in patients with inferolateral MAD compared with patients without inferolateral MAD(42% vs. 2%, p < 0.001). Proarrhythmic characteristics in terms of a high burden of premature ventricular complexes (PVC) and non-sustained ventricular tachycardia (VT) were more prevalent in patients with inferolateral MAD compared to patients without inferolateral MAD (67% vs. 23%, p < 0.001 and 63% vs 41%, p = 0.046, respectively). Appropriate implantable cardioverter defibrillator therapy during follow-up was comparable for IVF patients with or without inferolateral MAD (13% vs. 18%, p = 0.579). Conclusion A high prevalence of inferolateral MAD and MVP is a consistent finding in this large IVF cohort. The presence of inferolateral MAD is associated with a higher PVC burden and non-sustained VTs. Further research is needed to explain this potential interplay.

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“… 26 Implementing T1-mapping and CMR feature tracking could reveal sub-clinical abnormalities in IVF patients with inferolateral MAD that might correlate with arrhythmias. 25 , 27 …”

Section: Discussionmentioning

confidence: 99%

Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?

Verheul,

Guglielmo,

Groeneveld

et al. 2024

European Heart Journal - Cardiovascular Imaging

View full text Add to dashboard Cite

show abstract

“…Cardiac magnetic resonance (CMR) imaging has good spatial and tissue resolution. It can provide information on cardiac function, morphology, hemodynamics, and myocardial tissue characteristics, especially for CMR feature tracking technology, which can detect subtle cardiac morphological and functional changes early [ 13 , 14 ]. A previous study has reported the effect of MetS on LV structure and function by CMR feature tracking [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

The additive effect of metabolic syndrome on left ventricular impairment in patients with obstructive coronary artery disease assessed by 3.0 T cardiac magnetic resonance feature tracking

Min,

Gao,

Jiang

et al. 2024

Cardiovasc Diabetol

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Background Metabolic syndrome (MetS) can increase the risk of morbidity and mortality of cardiovascular disease and obstructive coronary artery disease (OCAD), which usually have a poor prognosis. This study aimed to explore the impact of MetS on left ventricular (LV) deformation and function in OCAD patients and investigate the independent factors of impaired LV function and deformation. Materials and methods A total of 121 patients with OCAD and 52 sex- and age-matched controls who underwent cardiac magnetic resonance scanning were enrolled in the study. All OCAD patients were divided into two groups: OCAD with MetS [OCAD(MetS+), n = 83] and OCAD without MetS [OCAD(MetS−), n = 38]. LV functional and global strain parameters were measured and compared among the three groups. Multivariable linear regression analyses were constructed to investigate the independent factors of LV impairment in OCAD patients. Logistic regression analysis and receiver operating characteristic (ROC) curve analysis were performed to test the prediction efficiency of MetS for LV impairment. Results From controls to the OCAD(MetS−) group to the OCAD(MetS+) group, LV mass (LVM) increased, and LV global function index (LVGFI) and LV global longitudinal peak strain (GLPS) decreased (all p < 0.05). Compared with the OCAD(MetS−) group, the LV GLPS declined significantly (p = 0.027), the LVM increased (p = 0.006), and the LVGFI decreased (p = 0.043) in the OCAD(MetS+) group. After adjustment for covariates in OCAD patients, MetS was an independent factor of decreased LV GLPS (β = − 0.211, p = 0.002) and increased LVM (β = 0.221, p = 0.003). The logistic multivariable regression analysis and ROC analysis showed that combined MetS improved the efficiency of predicting LV GLPS reduction (AUC = 0.88) and LVM (AUC = 0.89) increase. Conclusions MetS aggravated the damage of LV deformation and function in OCAD patients and was independently associated with LV deformation and impaired LV strain. Additionally, MetS increased the prediction efficiency of increased LVM and decreased LV GLPS. Early detection and intervention of MetS in patients with OCAD is of great significance.

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Imaging for the assessment of the arrhythmogenic potential of mitral valve prolapse

Esposito,

Gatti,

Trivieri

et al. 2023

Eur Radiol

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Additional value of cardiac magnetic resonance feature tracking parameters for the evaluation of the arrhythmic risk in patients with mitral valve prolapse

Cited by 9 publications

References 28 publications

Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?

Mitral annular disjunction in idiopathic ventricular fibrillation patients: just a bystander or a potential cause?

The additive effect of metabolic syndrome on left ventricular impairment in patients with obstructive coronary artery disease assessed by 3.0 T cardiac magnetic resonance feature tracking

Imaging for the assessment of the arrhythmogenic potential of mitral valve prolapse

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