Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study

Wildenauer, Dieter B.; Schwab, Sibylle G.; Albus, Margot; Hallmayer, Joachim; Lerer, Bernard; Maier, Wolfgang; Blackwood, Douglas; Muir, Walter; Clair, David St; Morris, Stewart W.; Moises, Hans W.; Yang, Ling; Kristbjarnarson, H.; Helgason, Tómas; Wiese, Claudia; Collier, David; Holmans, Peter; Daniels, J.; Rees, Mark I.; Asherson, Philip; Roberts, Queta; Cardno, Alastair G.; Arranz, Maria; Vallada, Homero; Ball, David; Kunugi, Hiroshi; Murray, Robin M.; Powell, John; Nanko, S.; Sham, Pak C.; Gill, M.; McGuffin, Peter; Owen, Michael John; Pulver, Ann E.; Antonarakis, Stylianos E.; Babb, Robert; Blouin, Jean Louis; DeMarchi, Nicola; Dombroski, Beth A.; Housman, David E.; Karayiorgou, Maria; Ott, Jürg; Kasch, Laura; Kazazian, Haig H.; Lasseter, Virginia K.; Loetscher, Erika; Luebbert, H.; Nestadt, Gerald; Ton, Carl C.; Wolyniec, Paula; Laurent, Claudine; Chaldée, Michel de; Thibaut, Florence; Jay, Maurice; Samolyk, D; Petit, Michel; Campion, Dominique; Mallet, Jacques; Straub, Richard E.; Maclean, Charles; Easter, Stephen M.; O'Neill, F. Anthony; Walsh, Dermot; Kendler, Kenneth S.; Gejman, Pablo V.; Cao, Qiuhe; Gershon, Elliot S.; Badner, Judith A.; Beshah, Ethiopia; Zhang, Jing; Riley, Brien P.; Rajagopalan, S; Mogudi-Carter, Mpala; Jenkins, Trefor; Williamson, Robert; DeLisi, Lynn E.; Garner, Chad; Kelly, Mary Margaret; LeDuc, C.; Cardon, Lon R.; Lichter, Jay B.; Harris, Tim; Loftus, J.; Shields, Gail; Comasi, Margarite; Vita, Antonio; Smith, Angela; J, Dann; Joslyn, Geoff; Gurling, Hugh; Kalsi, Gursharan; Brynjólfsson, Jón; Curtis, David; Sigmundsson, Thordur; Butler, Robert J.; Read, Timothy D.; Murphy, Patrick D.; Chen, Andrew Chih Hui; Pétursson, Hannes; Byerley, B; Hoff, M.; Holik, John; Coon, Hilary; Levinson, Douglas F.; Nancarrow, Derek J.; Crowe, Raymond R.; Andreasen, Nancy C.; Silverman, Jeremy M.; Mohs, Richard C.; Siever, Larry J.; Endicott, Jean; Sharpe, Lawrence; Walters, Marilyn K.; Lennon, David P.; Hayward, Nicholas K.; Sandkuijl, Lodewijk A.; Mowry, Bryan; Aschauer, Harald; Meszaros, K.; Lenzinger, E.; Fuchs, Karoline; Heiden, A.; Kruglyak, Leonid; Daly, Mark J.; Matise, Tara C.

doi:10.1002/(sici)1096-8628(19961122)67:6<580::aid-ajmg11>3.0.co;2-p

Cited by 166 publications

(2 citation statements)

References 43 publications

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“…With the increased sophistication of molecular studies and statistical power provided by the formation of large international collaborative efforts [Tsuang et al, ], evidence for candidate genes were identified at several chromosomes in linkage studies (although replication was not consistent), including 6p24‐22 [Antonarakis et al, ; Schwab et al, ; Straub et al, ; Wang et al, ; Moises et al, ; Wildenauer et al, ; Arolt et al, ; Maziade et al, ], 8p21‐22 [Pulver et al, ; Wildenauer et al, ], 10p11‐22 [Faraone et al, ; Schwab et al, ; Straub et al, ], 13q32 [Blouin et al, ], 15q13‐14 [Freedman et al, ; Kaufmann et al, ], and 22q12‐13 [Coon et al, ; Polymeropoulos et al, ; Pulver et al, ; Lasseter et al, ; Vallada et al, ; Moises et al, ; Gill et al, ; Ng et al, ].…”

Section: Other Evidence For Sex‐dependent or Sex‐specific Genetic Risk?mentioning

confidence: 99%

Sex differences in the genetic risk for schizophrenia: History of the evidence for sex‐specific and sex‐dependent effects

Goldstein¹,

Cherkerzian²,

Tsuang³

et al. 2013

American J of Med Genetics Pt B

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Although there is a long history to examinations of sex differences in the familial (and specifically, genetic) transmission of schizophrenia, there have been few investigators who have systematically and rigorously studied this issue. This is true even in light of population and clinical studies identifying significant sex differences in incidence, expression, neuroanatomic and functional brain abnormalities, and course of schizophrenia. This review highlights the history of work in this arena from studies of family transmission patterns, linkage and twin studies to the current molecular genetic strategies of large genome-wide association studies. Taken as a whole, the evidence supports the presence of genetic risks of which some are sexspecific (i.e., presence in one sex and not the other) or sexdependent (i.e., quantitative differences in risk between the sexes). Thus, a concerted effort to systematically investigate these questions is warranted and, as we argue here, necessary in order to fully understand the etiology of schizophrenia. Ó 2013 Wiley Periodicals, Inc.

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Section: Other Evidence For Sex‐dependent or Sex‐specific Genetic Risk?mentioning

confidence: 99%

Sex differences in the genetic risk for schizophrenia: History of the evidence for sex‐specific and sex‐dependent effects

Goldstein¹,

Cherkerzian²,

Tsuang³

et al. 2013

American J of Med Genetics Pt B

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show abstract

“…The human NOTCH4 gene is located on chromosome 6p21.3 [ 4 ], and several linkage studies have suggested that a susceptibility locus for schizophrenia is present on chromosome 6p [ 5 , 6 , 7 , 8 ]. In situ hybridization studies have determined that in embryonic and adult life, NOTCH4 transcripts are primarily restricted to endothelial cells [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals

et al. 2001

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Background: The human NOTCH4 gene is a candidate gene for schizophrenia due to its chromosomal location and neurobiological roles. In a British linkage study, NOTCH4 gene polymorphisms were highly associated with schizophrenia. In a Japanese case-control association study, however, these polymorphisms did not show significant associations with schizophrenia. We conducted a case-control study with Japanese subjects to explore an association between the triplet repeat polymorphism in the NOTCH4 gene and schizophrenia, including subtypes of schizophrenia, longitudinal disease course characteristics, and a positive family history for psychoses.

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What Is the Future of Research in Age-Related Macular Disease?

Bird¹

1997

Arch Ophthalmol

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Additional support for schizophrenia linkage on chromosomes 6 and 8: A multicenter study

Cited by 166 publications

References 43 publications

Sex differences in the genetic risk for schizophrenia: History of the evidence for sex‐specific and sex‐dependent effects

Sex differences in the genetic risk for schizophrenia: History of the evidence for sex‐specific and sex‐dependent effects

The (CTG)n polymorphism in the NOTCH4 gene is not associated with schizophrenia in Japanese individuals

What Is the Future of Research in Age-Related Macular Disease?

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