Additional Resistance to Moxifloxacin and Levofloxacin among MDR-TB Patients with Base Line Resistance to Ofloxacin at a Reference Laboratory

Additional Resistance to any Fluoroquinolones among Multidrug-resistant Mycobacterium tuberculosis Isolates from North Coastal Andhra Pradesh, India

“…Unfortunately, India has high TB burden and also is a high MDR-TB burden country, 6 and by inference harbours large extensively-drug resistant tuberculosis (XDR-TB) population. FQ resistance may thus be a more prevalent than actually reported and can threaten TB control programmes 1 . Studies from India have demonstrated the prevalence of FQ resistance in MDR-TB patients 1,3,7,8,9 but none from North Coastal Andhra Pradesh.…”

“…FQ resistance may thus be a more prevalent than actually reported and can threaten TB control programmes 1 . Studies from India have demonstrated the prevalence of FQ resistance in MDR-TB patients 1,3,7,8,9 but none from North Coastal Andhra Pradesh. Hence we studied the proportion of FQ resistance among MDR-TB/RR-TB and also the proportion of their cross-resistance among MDR-TB/RR-TB isolates.…”

“…I n fe c t i o n w i t h M y c o b a c t e r i u m tuberculosis resistant to isoniazid (H) and rifampicin (R) also called as MDR-TB or RR TB, [1][2][3] leads to treatment with less potent, more toxic and expensive second-line anti-TB drugs (SLD). Fluoroquinolones (FQ) are crucial and integral part of drug resistant tuberculosis (DR-TB) treatment regimens 1,3,4 .…”

“…I n fe c t i o n w i t h M y c o b a c t e r i u m tuberculosis resistant to isoniazid (H) and rifampicin (R) also called as MDR-TB or RR TB, [1][2][3] leads to treatment with less potent, more toxic and expensive second-line anti-TB drugs (SLD). Fluoroquinolones (FQ) are crucial and integral part of drug resistant tuberculosis (DR-TB) treatment regimens 1,3,4 . Wide and illogic use of FQ, either for tuberculosis (TB) or other infections of respiratory tract, is responsible for increasing FQ resistance in MDR-TB, and lead to a situation where treatment options are narrowed 1,3 .…”

“…Fluoroquinolones (FQ) are crucial and integral part of drug resistant tuberculosis (DR-TB) treatment regimens 1,3,4 . Wide and illogic use of FQ, either for tuberculosis (TB) or other infections of respiratory tract, is responsible for increasing FQ resistance in MDR-TB, and lead to a situation where treatment options are narrowed 1,3 . FQ resistance and poor treatment outcomes in MDR-TB have been reported in studies 4,5 .…”