Additional medical costs of chronic conditions among adolescent and young adult cancer survivors

Abdelhadi, Ola A.; Joseph, Jill G.; Pollock, Brad H.; Keegan, Theresa H.M.

doi:10.1007/s11764-021-01044-4

Cited by 14 publications

(16 citation statements)

References 37 publications

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“…In the current study, AYA survivors were significantly more likely to be current or former smokers than controls, similar to previous findings that AYA survivors are more likely to smoke than the general population 43 . It has also been shown that AYA survivors with chronic health conditions are more likely to smoke than AYAs without chronic health conditions and that smoking co‐occurs with other modifiable CVD risk factors in cancer survivors 44,45 . Taken together with our findings that AYA survivors who are current or former smokers have close to twice the odds of CVD as those who never smoked, interventions aimed at smoking cessation and prevention are needed in this population.…”

Section: Discussionsupporting

confidence: 90%

Cardiovascular disease in adolescent and young adult cancer survivors: Impact of sociodemographic and modifiable risk factors

Berkman

Andersen

Roth

et al. 2022

Cancer

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Background: There is a growing population of adolescent and young adult (AYA) cancer survivors (ages 15-39 years), and they have an elevated risk of developing cardiovascular disease (CVD). Little is known about the contribution of sociodemographic and modifiable factors to the risk of CVD in AYA survivors and whether these factors differentially modulate their risk compared with that in the general population. The current study sought to fill these gaps.Methods: Self-reported data from the US National Health Interview Survey (2009)(2010)(2011)(2012)(2013)(2014)(2015)(2016)(2017)(2018) were used to identify AYA cancer survivors (≥2 years postdiagnosis) and agematched and sex-matched controls. The risk of CVD based on sociodemographic factors (sex, race/ethnicity, income, education) and modifiable risk factors (diabetes, body mass index, smoking, physical activity) was determined within and between survivors and controls using logistic regression models.

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Section: Discussionsupporting

confidence: 90%

Cardiovascular disease in adolescent and young adult cancer survivors: Impact of sociodemographic and modifiable risk factors

Berkman

Andersen

Roth

et al. 2022

Cancer

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“…Which (long-term) physical issues develop mainly depends on the location of the primary tumor and the type of treatment received [42][43][44]. Compared to siblings and the general population with no history of cancer, AYAs are at greater risk of potentially life-threatening chronic medical conditions [43][44][45]. These long-term complications can lead to significant medical expenses and healthcare utilization [45].…”

Section: Physical Issuesmentioning

confidence: 99%

“…Compared to siblings and the general population with no history of cancer, AYAs are at greater risk of potentially life-threatening chronic medical conditions [43][44][45]. These long-term complications can lead to significant medical expenses and healthcare utilization [45].…”

Section: Physical Issuesmentioning

confidence: 99%

Adolescent and Young Adult (AYA) Cancer Survivorship Practices: An Overview

Janssen

Graaf

Meer

et al. 2021

Cancers

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Worldwide, more than 1.2 million adolescents and young adults (AYAs; those aged 15–39 years) are diagnosed with cancer each year. Although considerable variability exists according to cancer site and stage of disease, the 5-year relative survival at the time of diagnosis has been estimated at >80% for all AYA patients with cancer combined. Extensive survivorship research in recent decades has focused on patients diagnosed with cancer as children (<15 years) and older adults (>39 years), yet few studies to date have reported outcomes specifically for patients diagnosed as AYAs. With increasing incidence and improving survival for many tumor types, leading to the majority of AYA patients with cancer becoming long-term survivors, there is a critical need for research efforts to inform the survivorship care of this growing population. This article describes the population of AYA cancer survivors according to their epidemiology and late and long-term effects, the challenges and models of AYA survivorship care, as well as future opportunities for research and healthcare.

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“…The selected studies were conducted across 13 countries, predominantly in the United States (n = 12, 40%) [25][26][27][28][29][30][31][32][33][34][35][36] and Canada (n = 5, 17%). [37][38][39][40][41] Australia 42,43 and the Netherlands 44,45 reported two studies each while nine other countries including France, Chile, Korea, India, Mexico, Spain, Egypt, Thailand, and China had one study (Table 1, Table S2).…”

Section: Study Settingsmentioning

confidence: 99%

“…More than half of the studies (n = 16, 53%) reported costs for both children and adolescents 0-19 years. Other studies were exclusive to children 0 to 14 years (n = 4, 13%), 39,[47][48][49] AYA aged 15 to 39 years (n = 5, 17%), 25,26,30,33,36 or adolescents 15 to 19 years (n = 1, 3%). 40 Four studies (n = 4, 13%) covered the whole spectrum of children and AYA aged 0-39 years 27,28,31,46 (Table 1, Table S1).…”

Section: Participant Age Groupmentioning

confidence: 99%

Healthcare costs of cancer among children, adolescents, and young adults: A scoping review

Nabukalu,

Gordon,

Lowe

et al. 2024

Cancer Medicine

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ObjectiveTo collate and critically review international evidence on the direct health system costs of children and adolescents and young adults (AYA) with cancer.MethodsWe conducted searches in PubMed, MEDLINE, CINAHL, and Scopus. Articles were limited to studies involving people aged 0–39 years at cancer diagnosis and published from 2012 to 2022. Two reviewers screened the articles and evaluated the studies using the Consolidated Health Economic Evaluation Reporting Standards checklist. The reviewers synthesized the findings using a narrative approach and presented the costs in 2022 US dollars for comparability.ResultsOverall, the mean healthcare costs for all cancers in the 5 years post diagnosis ranged from US$36,670 among children in Korea to US$127,946 among AYA in the USA.During the first year, the mean costs among children 0–14 years ranged from US$34,953 in Chile to over US$130,000 in Canada. These were higher than the costs for AYA, estimated at US$61,855 in Canada. At the end of life, the mean costs were estimated at over US$300,000 among children and US$235,265 among adolescents in Canada.Leukemia was the most expensive cancer type, estimated at US$50,133 in Chile, to US$152,533 among children in Canada. Overall, more than a third of the total cost is related to hospitalizations. All the included studies were of good quality.ConclusionsHealthcare costs associated with cancer are substantial among children, and AYA. More research is needed on the cost of cancer in low‐ and middle‐income countries and harmonization of costs across countries.

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Additional medical costs of chronic conditions among adolescent and young adult cancer survivors

Cited by 14 publications

References 37 publications

Cardiovascular disease in adolescent and young adult cancer survivors: Impact of sociodemographic and modifiable risk factors

Cardiovascular disease in adolescent and young adult cancer survivors: Impact of sociodemographic and modifiable risk factors

Adolescent and Young Adult (AYA) Cancer Survivorship Practices: An Overview

Healthcare costs of cancer among children, adolescents, and young adults: A scoping review

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