Additional Effects of Nutritional Antioxidant Supplementation on Peripheral Muscle during Pulmonary Rehabilitation in COPD Patients: A Randomized Controlled Trial

Gouzi, Farès; Maury, Jonathan; Héraud, Nelly; Molinari, Nicolas; Bertet, Héléna; Ayoub, Bronia; Blaquière, Marine; Bughin, François; Rigal, Philippe de; Poulain, Martine; Pincemaïl, Joël; Cristol, Jean Paul; Laoudj-Chenivesse, Dalila; Mercier, Jacques; Préfaut, Christian; Pomiès, Pascal; Hayot, Maurice

doi:10.1155/2019/5496346

Cited by 25 publications

(37 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An updated study in 2019 showed that oral antioxidant supplementation, which comprised tocopherol, ascorbate, zinc gluconate, and selenomethionine during moderate-intensity exercise training for 28 days, increased muscle strength, serum protein, and plasma antioxidant compounds in COPD patients, when compared to non-antioxidant supplementation during exercise training. 37 Moreover, elderly people showed low antioxidant status, especially in L-ascorbic acid (Vit C), including lower muscle mass, strength and increased walking speed. 38,39 Previous evidence showed that supplement of Vit C combined with alpha-tocopherol for 4 weeks decreased the creatine kinase (CK) level in marathon runners, 40 and furthermore, stimulated the immune function by activating white blood cell proliferation.…”

Section: Introductionmentioning

confidence: 99%

Prototype Star Fruit-Honey Product and Effectiveness on Antixidants, Inflammation and Walking Distance in Participants with Stable Chronic Obstructive Pulmonary Disease (COPD)

Pothasak¹,

Leelarungrayub²,

Natakankitkul³

et al. 2020

View full text Add to dashboard Cite

Background: Star fruit (Averrhoa carambola L.) is a seasonal fruit, which has proven antioxidant and inflammation activities in vitro. However, sweet-type is more available than sour-type. Therefore, developing a new product from sweet-type star fruit, and evaluating its effectiveness on antioxidants and inflammation have been very challenging. Objectives: The aims were to develop a prototype product from sweet-type star fruit and evaluate its effectiveness with or without walking exercise on participants with stable chronic obstructive pulmonary disease (COPD). Methods: The prototype product of sweet-type star fruit was prepared industrially by mixing with honey before nutrients such as L-ascorbic acid (Vit C) and total phenolic compound, and contaminants like chemicals, microbials and oxalic acid were evaluated. Effectiveness of this product on antioxidents, inflammation and physical function was evaluated in participants with stable COPD with and without walking exercise, and compared to walking exercise and control participants. Two spoons of the product (20 g) in sterile warm water (150 mL) were guided and consumed twice daily for 4 weeks, whereas the walking exercise was prescribed with moderate intensity at home for 30 min 3 days per week. Plasma Vit C, total antioxidant capacity (TAC), malondialdehyde (MDA), tumor necrotic factoralpha (TNF-∝) and 6-minutes walking distance (6MWD) were evaluated before and after the 4-week study period. Results: The prototype product composed of star fruit juice with honey (1:1, v:v). Main nutrients were composed of ash (0.4 g), carbohydrate (74.59 g), lipid (2.88 g), protein (0.57 g) and 326.56 kcal of total energy, whereas Vit C and total phenolic compound were equivalent to 0.25 ± 0.11 mg and 144.89 ± 2.51 µg gallic acid equivalent in a 100 gram of product. The results of chemicals and microbials showed safety under food conditions. The results of study compared the ages of stable COPD participants between those of the controls (n=10, 69.20±1.40 years), and those with star fruit juice and honey supplement (n=20, 71.25 ± 6.01 years), walking exercise (n=15, 60.60±3.38 years), and supplement with walking exercise (n=15, 64.40±1.63 years) and no statistical difference was shown in any parameters in the control group. Whereas, the plasma Vit C and TAC levels increased, and MDA and TNF-∝ levels reduced significantly, in the supplement consumption group, which was in contrast to the Vit C, MDA and TNF-∝ levels in the walking exercise group. However, the TAC level increased significantly when the walking exercise was completed. When the prototype product was applied to the walking exercise, the levels of Vit C and TAC increased, and MDA and TNF-∝ levels reduced significantly. Whereas, the supplement levels increased significantly in all of the groups, especially in the 6MWD. Conclusion: This study proposed that sweet-type star fruit can be prepared industrially by mixing with honey, and be developed as a new commercial product with antioxidant and inflammation activities for p...

show abstract

Section: Introductionmentioning

confidence: 99%

Prototype Star Fruit-Honey Product and Effectiveness on Antixidants, Inflammation and Walking Distance in Participants with Stable Chronic Obstructive Pulmonary Disease (COPD)

Pothasak¹,

Leelarungrayub²,

Natakankitkul³

et al. 2020

View full text Add to dashboard Cite

show abstract

“…76 Furthermore, a nutritional supplement characterized by the presence of both, with specific contributions equal to 180 mg/day of vitamin C and 30 mg day α-tocopherol, associated with zinc (15 mg/day) and selenium (50 μg/ day) in patients with COPD undergoing pulmonary rehabilitation treatment showed significant improvements in muscle strength, suggesting a potential "add-on" effect. 77 Other anti-oxidants, such as beta-cryptoxanthin, lutein zeaxanthin, retinol, beta-carotene and lycopene, both blood and food, were positively associated with FEV1%, supporting the hypothesis that an imbalance in the state antioxidant/oxidant is associated with chronic airflow limitation. 78 In conclusion, it is favorably useful to modify the lifestyle by adding (a) large quantities of fruit, vegetables (5 portions per day: 3 of fruit and 2 of vegetables, 1 raw and cooked), 52 (b) whole foods, to increase the fiber share, 79 and (c) antioxidants in order to improve FEV1 and oxidative stress.…”

Section: Fiber and Antioxidantsmentioning

confidence: 76%

<p>Food Pyramid for Subjects with Chronic Obstructive Pulmonary Diseases</p>

Rondanelli¹,

Faliva²,

Peroni³

et al. 2020

COPD

View full text Add to dashboard Cite

Nutritional problems are an important part of rehabilitation for chronic obstructive pulmonary disease (COPD) patients. COPD patients often present with malnutrition, sarcopenia, and osteoporosis with possible onset of cachexia, with an inadequate dietary intake and a poor quality of life. Moreover, diet plays a pivotal role in patients with COPD through three mechanisms: regulation of carbon dioxide produced/oxygen consumed, inflammation, and oxidative stress. A narrative review based on 99 eligible studies was performed to evaluate current evidence regarding optimum diet therapy for the management of COPD, and then a food pyramid was built accordingly. The food pyramid proposal will serve to guide energy and dietary intake in order to prevent and treat nutritionally related COPD complications and to manage progression and COPD-related symptoms. The nutrition pyramid described in our narrative review is hypothetical, even in light of several limitations of the present review; the main limitation is the fact that to date there are no randomized controlled trials in the literature clearly showing that improved nutrition, via the regulation of carbon dioxide produced/oxygen consumed, inflammation and oxidative stress, improves symptoms and/or progression of COPD. Even if this nutritional pyramid is hypothetical, we hope that it can serve the valuable purpose of helping researchers focus on the often-ignored possible connections between body composition, nutrition, and COPD.

show abstract

“…Only in malnourished patients has nutritional supplementation demonstrated significant improvements for 6-minute walk test, respiratory muscle strength and health status. 286 A 12-month nutritional intervention in muscle wasted patients had no effect on physical capacity but physical activity was significantly higher. 287…”

Section: Therapy Relevant To All Patients With Copdmentioning

confidence: 94%