Additional diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis

Vallbracht, Inka; Helmke, K.

doi:10.1016/j.autrev.2005.02.001

Cited by 38 publications

(33 citation statements)

References 34 publications

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“…The diagnostic and prognostic value for detection of anti-CCP antibodies was shown to be specific to RA patients in various populations (Dubucquoi et al, 2004;Vallbracht and Helmke, 2005;Gupta et al, 2009). In the present study, 56.8% of the RA patients were found positive to anti-CCP antibodies while 77.8% were positive to RF antibodies.…”

Section: Discussionmentioning

confidence: 56%

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

et al. 2012

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Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease affecting ~ 1% of the population worldwide. The genome wide association studies on RA patients revealed linkage with 1p36 locus containing peptidyl arginine deiminase 4 (PADI4) genes. Case-control association studies and mRNA stability assays reported the association of PADI4 gene with RA in Korean and Japanese populations. However, such association was not found in Spanish population. Differences in the association of PADI4 with RA in different populations prompted the present study in Indian population. Anti-CCP antibodies, RF antibody, disease activity scores at 28 joints (DAS28) and mutations in three exons of PADI4 were investigated in RA patients and control group. Among the patients anti-CCP antibody levels were found to be associated with high DAS28 values (r = 0.4526, P < 0.0001). Polymorphism in exon-4 (padi4_104, [rs1748033]) of PADI4 showed significant association of 'C' allele with RA in the study population (P = 0.0008). Polymorphism in exon-3 (padi4_92, [rs874881]) also exhibited moderate association with the disease (P = 0.075). However, no association of the disease was found with the SNPs padi4_89 [rs11203366] and padi4_90 [rs11203367] in exon-2 of PADI4.

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Section: Discussionmentioning

confidence: 56%

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

et al. 2012

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“…The etiology of inflammatory arthritis has been most extensively studied in RA, in which association with specific MHC II alleles and infiltration of synovial tissue by CD4 ϩ T cells suggest a role for CD4 ϩ T cells (2). However, a role for autoantibodies is also implied by the association between disease prognosis and the presence of autoantibodies to IgG (rheumatoid factor) and to cyclic citrullinated peptide (CCP) (2,3). RA shows by far its strongest genetic linkages with particular HLA genes, especially those encoding specific ␤-chains of the HLA-DR molecule (2,4), and recent evidence has shown that specific polymorphisms of the PTPN22 molecule (a phosphatase that controls the degree of T cell activation) can also contribute to RA susceptibility (5).…”

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confidence: 99%

“…I nflammatory arthritis can develop in a variety of human autoimmune diseases (including systemic lupus erythematosus, inflammatory bowel disease, and psoriasis) and is the hallmark of rheumatoid arthritis (RA) 3 (1, 2). RA patients develop chronic inflammatory arthritis with progressive damage to articular structures, including cartilage, bone, tendons, and ligaments and can also develop extra-articular manifestations affecting vasculature and organs such as the lungs (2).…”

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confidence: 99%

CD4+ T Cells Recognizing a Single Self-Peptide Expressed by APCs Induce Spontaneous Autoimmune Arthritis

Rankin

Reed

et al. 2008

The Journal of Immunology

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We have examined processes leading to the spontaneous development of autoimmune inflammatory arthritis in transgenic mice containing CD4+ T cells targeted to a nominal Ag (hemagglutinin (HA)) and coexpressing HA driven by a MHC class II promoter. Despite being subjected to multiple tolerance mechanisms, autoreactive CD4+ T cells accumulate in the periphery of these mice and promote systemic proinflammatory cytokine production. The majority of mice spontaneously develop inflammatory arthritis, which is accompanied by an enhanced regional immune response in lymph nodes draining major joints. Arthritis development is accompanied by systemic B cell activation; however, neither B cells nor Ab is required for arthritis development, since disease develops in a B cell-deficient background. Moreover, arthritis also develops in a recombinase activating gene-deficient background, indicating that the disease process is driven by CD4+ T cells recognizing the neo-self HA Ag. These findings show that autoreactive CD4+ T cells recognizing a single self-Ag, expressed by systemically distributed APCs, can induce arthritis via a mechanism that is independent of their ability to provide help for autoantibody production.

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“…Anti-CCP has been reported to be better than RF, to predict the disease activity over 3 years. In addition, percentages of the anti-CCP-positive patients were reported to be higher among patients with severe disease activity than in those with mild disease activity (19,20). Although Kastbom et al (21) did not observe a significant difference between anti-CCP-positive and anti-CCP-negative patients in number of the total swollen joints, CRP level and DAS-28; they defined a positive correlation between the incidence of anti-CCP positive and the number of met ACR criteria.…”

Section: Discussionmentioning

confidence: 99%

Romatoid Artritli Hastalarda Serum Anti-Cyclic Citrullinated Peptid Antikor Düzeyleri ve Hastalık Aktivitesi Arasındaki İlişki

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2012

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Additional diagnostic and clinical value of anti-cyclic citrullinated peptide antibodies compared with rheumatoid factor isotypes in rheumatoid arthritis

Cited by 38 publications

References 34 publications

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

Association of single nucleotide polymorphisms (SNPs) of <i>PADI4</i> gene with rheumatoid arthritis (RA) in Indian population

CD4+ T Cells Recognizing a Single Self-Peptide Expressed by APCs Induce Spontaneous Autoimmune Arthritis

Romatoid Artritli Hastalarda Serum Anti-Cyclic Citrullinated Peptid Antikor Düzeyleri ve Hastalık Aktivitesi Arasındaki İlişki

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