Additional case of acute cellular kidney rejection associated with the presence of antibodies to the red blood cell Kidd antigen

Hamilton, Mary G.; Singh, Vivekanand; Warady, Bradley A.

doi:10.1111/j.1399-3046.2008.00954.x

Cited by 10 publications

(11 citation statements)

References 3 publications

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“…7 There are 2 reports of plasma cell-rich acute cellular rejection and one Banff 1A cellular rejection, with development of anti-Jk antibodies between 2 and 10 years posttransplant in nonadherent patients, which could have stimulated de novo donor-specific Jk antibody development. 5,6,8 Lastly, a case of C4d-positive AMR at 5 years posttransplant was reported with simultaneous anti-Jk a antibodies resulting in graft loss. 9 Notably, our case was consistently C4d-negative on multiple biopsies, suggesting that anti- Jk a antibodies do not always fix complement.…”

Section: Discussionmentioning

confidence: 99%

Hyperacute Antibody-mediated Rejection Associated With Red Blood Cell Antibodies

Shaw

Gibson

Wiebe

et al. 2019

Transplantation Direct

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Section: Discussionmentioning

confidence: 99%

Hyperacute Antibody-mediated Rejection Associated With Red Blood Cell Antibodies

Shaw

Gibson

Wiebe

et al. 2019

Transplantation Direct

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“…9 Hamilton et al 8 make the suggestion that the anti-Jk b was synthesized by the plasma cells identified in the kidney. Hamilton et al 10 described another 19-year-old woman who exhibited anti-Jk a 7 years after renal transplantation. Again, the patient was described as noncompliant with her immunosuppressive regimen.…”

Section: Discussionmentioning

confidence: 99%

Implications of the Kidd blood group system in renal transplantation

Rourk

Squires

2012

Immunohematology

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The association of the Kidd blood group system with hemolytic transfusion reactions and hemolytic disease of the newborn is well known. The Kidd antigens, which are localized to the HUT/UT-B urea transport protein, are found on red blood cells and the endothelial cells of the blood vessels of the medulla of the kidney. Recently it has been suggested that these antigens might play a role as minor histocompatibility antigens in renal transplantation. In the current case, the appearance of an anti-Jk b 10 years after renal transplantation associated with early renal allograft rejection further supports the potential importance of these antigens in renal transplantation and allograft rejection.

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“…Reports suggest a role for JK antibodies in histocompatibility and renal graft survival. Five published cases describe renal graft rejection at the time of concurrent anti‐Jk a or anti‐Jk b detection . The rejection episodes occurred up to 9 years posttransplant and, in at least 3 cases, were associated with non‐compliance with the patient's immunosuppressive therapy.…”

Section: Kidd System Antibodies and Their Clinical Importancementioning

confidence: 99%

Kidd blood group system: outwardly simple with hidden complexity

Hamilton

2018

ISBT Science Series

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The basics of the Kidd blood group system have been well described. Two of the three antigens, Jka and Jkb, are polymorphic. The third, Jk3, is of very high prevalence in all populations except in individuals of Polynesian and Finnish extraction. Jk (a−b−) red cells do not express Jk3. The antigens are encoded by SLC14A1 gene on chromosome 18. JK*01 allele differs from JK*02 at nt 838 (G/A) and in the protein, at amino acid 280, Jka expression is associated with aspartate and asparagine is associated with Jkb. The genetic background of the dominantly inherited In(Jk) Jk(a−b−) is due to an 84 bp deletion in ZFN850 on chromosome 19. Antibodies against all three antigens are clinically important. They can cause immediate haemolytic transfusion reactions and are a frequent cause of delayed transfusion reactions. Haemolytic disease of the foetus and newborn due to JK antibodies is generally much less severe than the response to incompatible transfusion. The JK protein on red cells functions as a urea transporter. Complexity in the system is due to the number of alternate alleles described. ISBT recognizes 24 alleles that silence Jka/Jkb expression and 7 alleles causing weak or partial expression of Jka or Jkb. These alleles can result in serological typing discrepancies, discordant serological/molecular results and production of an apparent Kidd alloantibody by an antigen‐positive individual. JK antigens may serve as minor histocompatibility antigens. The antibodies may play a role in renal graft survival when a JK‐incompatible donor kidney is transplanted.

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Additional case of acute cellular kidney rejection associated with the presence of antibodies to the red blood cell Kidd antigen

Cited by 10 publications

References 3 publications

Hyperacute Antibody-mediated Rejection Associated With Red Blood Cell Antibodies

Hyperacute Antibody-mediated Rejection Associated With Red Blood Cell Antibodies

Implications of the Kidd blood group system in renal transplantation

Kidd blood group system: outwardly simple with hidden complexity

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