Additional Analyses for the Published Primary Norfloxacin Prophylaxis for APASL-Defined Acute-on-Chronic Liver Failure

Crocombe, Dominic; Freemantle, Nick; O’Brien, Alastair

doi:10.14309/ajg.0000000000001702

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2023

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“… 9 A recent trial of primary norfloxacin prophylaxis effectively prevents bacterial infections in patients with ACLF that recruited 172 patients in India. 67 Mortality also significantly improved in the treatment arm, 68 but more patients developed candiduria in the norfloxacin group. In contrast, the AntibioCor study of 284 patients with severe alcohol-associated hepatitis showed that the addition of amoxicillin/clavulanate to prednisolone reduced infection rates but did not extend survival and the authors do not recommend prophylaxis for these patients.…”

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confidence: 91%