Addition of Hyperoxic Component to Adaptation to Hypoxia Prevents Impairments Induced by Low Doses of Toxicants (Free Radical Oxidation and Proteins of HSP Family)

Сазонтова, Т. Г.; Stryapko, N. V.; Arkhipenko, Y.-U. V.

doi:10.1007/s10517-016-3157-0

Cited by 6 publications

(3 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“… 29 , 30 But animal research found that intermittent hypoxia-hyperoxia has greater protective preventive effect than intermittent hypoxia-normoxia does. 31 Further studies are warranted to better understand the biological consequences and possible risks in replacing normoxia with the hyperoxia in intermittent hypoxia conditioning.…”

Section: Protocols and Parameters Of Intermittent Hypoxiamentioning

confidence: 99%

Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy

Zhang,

Zhao,

et al. 2023

Int. J. Med. Sci.

View full text Add to dashboard Cite

Severe hypoxia can induce a range of systemic disorders; however, surprising resilience can be obtained through sublethal adaptation to hypoxia, a process termed as hypoxic conditioning. A particular form of this strategy, known as intermittent hypoxia conditioning hormesis, alternates exposure to hypoxic and normoxic conditions, facilitating adaptation to reduced oxygen availability. This technique, originally employed in sports and high-altitude medicine, has shown promise in multiple pathologies when applied with calibrated mild to moderate hypoxia and appropriate hypoxic cycles. Recent studies have extensively investigated the protective role of intermittent hypoxia conditioning and its underlying mechanisms using animal models, demonstrating its potential in organ protection. This involves a range of processes such as reduction of oxidative stress, inflammation, and apoptosis, along with enhancement of hypoxic gene expression, among others. Given that intermittent hypoxia conditioning fosters beneficial physiological responses across multiple organs and systems, this review presents a comprehensive analysis of existing studies on intermittent hypoxia and its potential advantages in various organs. It aims to draw attention to the possibility of clinically applying intermittent hypoxia conditioning as a multi-organ protective strategy. This review comprehensively discusses the protective effects of intermittent hypoxia across multiple systems, outlines potential procedures for implementing intermittent hypoxia, and provides a brief overview of the potential protective mechanisms of intermittent hypoxia.

show abstract

Section: Protocols and Parameters Of Intermittent Hypoxiamentioning

confidence: 99%

Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy

Zhang,

Zhao,

et al. 2023

Int. J. Med. Sci.

View full text Add to dashboard Cite

show abstract

“…Наблюдая пользу и положительное влияние адаптивных реакций в ответ на гипоксию, ученые исследовали различные https://doi.org/10.26442/20751753.2023.5.202272 режимы гипоксических тренировок. Наиболее перспективным представляется метод интервальных гипоксическихгипероксических тренировок (ИГГТ), где периоды нормоксии (дыхание атмосферным воздухом) заменяются дыханием гипероксичной смесью, содержащей 30-35% кислорода [45]. По мнению некоторых исследователей, последовательная смена гипоксических и гипероксических (вместо нормоксических) стимулов во время ИГГТ позволяет усилить сигнал, индуцированный АФК, без усиления гипоксии.…”

Section: модификация образа жизниunclassified

Non-alcoholic fatty liver disease: from understanding risk factors to finding optimal treatment regimens: A review

Teplyuk,

Kaisina,

Ibragimova

et al. 2023

Consilium Medicum

View full text Add to dashboard Cite

Non-alcoholic fatty liver disease (NAFLD) is now a major risk factor for death among patients with liver disease. Currently, drugs that primarily affect surrogate markers of NAFLD are available. However, none of these drugs showed a significant effect on the course of steatohepatitis and fibrogenesis. The search for the most relevant lifestyle modification programs is still a priority in comprehensive treatment. A clinical case of follow-up of a comorbid patient is presented. Despite comprehensive treatment, disease regression was not achieved. NAFLD therapy remains a relevant issue. Finding new ways to affect the NAFLD course and individualize treatment approaches is necessary.

show abstract

“…The total breathing time of GHM during one session is 10–15 min with a total session duration of 15–100 min ( Serebrovskaya and Xi, 2016 ). There are variants of IHT with alternating hypoxic and hyperoxic episodes (hypoxia-hyperoxia) ( Sazontova et al, 2016 ; Hadanny and Efrati, 2020 ) or hypoxic and hypercapnic episodes (hypoxia-hypercapnia) ( Welch et al, 2022 ).…”

Section: Basic Technology Of Normobaric Intermittent Hypoxic Trainingmentioning

confidence: 99%

Intermittent Hypoxic Training as an Effective Tool for Increasing the Adaptive Potential, Endurance and Working Capacity of the Brain

Рыбникова¹,

Nalivaeva²,

Zenko³

et al. 2022

Front. Neurosci.

View full text Add to dashboard Cite

This review is devoted to the phenomenon of intermittent hypoxic training and is aimed at drawing the attention of researchers to the necessity of studying the mechanisms mediating the positive, particularly neuroprotective, effects of hypoxic training at the molecular level. The review briefly describes the historical aspects of studying the beneficial effects of mild hypoxia, as well as the use of hypoxic training in medicine and sports. The physiological mechanisms of hypoxic adaptation, models of hypoxic training and their effectiveness are summarized, giving examples of their beneficial effects in various organs including the brain. The review emphasizes a high, far from being realized at present, potential of hypoxic training in preventive and clinical medicine especially in the area of neurodegeneration and age-related cognitive decline.

show abstract

Addition of Hyperoxic Component to Adaptation to Hypoxia Prevents Impairments Induced by Low Doses of Toxicants (Free Radical Oxidation and Proteins of HSP Family)

Cited by 6 publications

References 6 publications

Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy

Intermittent Hypoxia Conditioning: A Potential Multi-Organ Protective Therapeutic Strategy

Non-alcoholic fatty liver disease: from understanding risk factors to finding optimal treatment regimens: A review

Intermittent Hypoxic Training as an Effective Tool for Increasing the Adaptive Potential, Endurance and Working Capacity of the Brain

Contact Info

Product

Resources

About