Addition of flavonols and polysaccharides as excipient ingredients into epicatechin rich green tea extract inhibited free radical formation and glucose uptake

Abstract

Results from the current study suggested that whole green tea components rich in flavonols and polysaccharides could be potential hypoglycemic excipient ingredients into green tea catechins by enhancing catechin absorption.

EGCG Promotes FUS Condensate Formation in a Methylation-Dependent Manner

“…Several studies have demonstrated the role of green tea catechins in neuroprotection, with epigallocatechin gallate (EGCG) being widely studied because it constitutes 65% of all catechins in green tea [ 8 , 9 , 10 , 11 ]. The green tea catechins play a variety of roles in neuroprotection, such as exerting (i) anti-oxidative properties through radical scavenging and metal ion chelation [ 12 , 13 , 14 ], (ii) anti-apoptotic properties through the reduction in pro-apoptotic gene expression [ 15 ], (iii) anti-inflammatory properties through the inhibition of microglia activation [ 16 ], and (iv) anti-amyloidogenic properties through the remodeling of toxic aggregates [ 8 , 17 ]. The latter role of catechins in neuroprotection is of great interest as it counteracts the hallmark of NDs (formation of protein aggregates), which is thought to drive the process of neurodegeneration.…”

Effect of Characterized Green Tea Extraction Methods and Formulations on Enzymatic Starch Hydrolysis and Intestinal Glucose Transport

“…In addition to catechins and polysaccharides, flavonol extracts obtained via the enzyme treatment of green tea contained quercetin, myricetin, and kaempferol, which are known to have biological functions such as inhibition activities of α-glucosidase. − In addition, several studies noted that dietary flavonol monoglucosides competitively inhibited glucose transport through the intestinal Na + -dependent glucose transporter (SGLT1) . In terms of the synergetic effects of catechin extracts formulated with excipient ingredients (polysaccharides and flavonols), both enzymatic hydrolysis and messenger RNA (mRNA) expression of SGLT1 or GLUT2 were modulated after consumption with wheat or rice starch. ,, However, the exact mechanism involved in the potential impact on postprandial glucose levels is still unclear.…”

“…25 In terms of the synergetic effects of catechin extracts formulated with excipient ingredients (polysaccharides and flavonols), both enzymatic hydrolysis and messenger RNA (mRNA) expression of SGLT1 or GLUT2 were modulated after consumption with wheat or rice starch. 16,26,27 the exact mechanism involved in the potential impact on postprandial glucose levels is still unclear. The composition of those bioactive ingredients from green tea varies according to processing and drinking methods, and such methods could provide various ranges of biological activities such as the hypoglycemic effect.…”

Characterized Polysaccharides from Green Tea Inhibited Starch Hydrolysis and Glucose Intestinal Uptake by Inducing Microstructural Changes of Wheat Starch

“…24 Studies of glucose transport have shown that polysaccharides from green tea could inhibit intestinal glucose transport by gene modulation of the intestinal transport protein for glucose uptake. 18,25 The inhibitory effect of the polysaccharides on the blood glucose levels from starch consumption has also been confirmed in several in vivo studies. 13,26 The results from one study suggested that the polysaccharides obtained during the extraction of catechins from green tea could not only be divided into several fractions by processing but also provide various biological functions due to their specific physiochemical properties.…”