Addition of dexmedetomidine prolongs duration of vasodilation induced by sympathetic block with mepivacaine in dogs

Tezuka, Masatomo; Kitajima, Toshimitsu; Yamaguchi, Shigeki; Kimura, Yoshiyuki; Hamaguchi, Shinsuke

doi:10.1016/j.rapm.2004.03.004

Cited by 3 publications

(4 citation statements)

References 26 publications

(19 reference statements)

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“…sympathetic block) when combined with mepivacaine for stellate ganglionic blockade (Kimura et al. 2001; Tezuka et al. 2004).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, two canine studies have demonstrated that both clonidine and dexmedetomidine will prolong the duration of vasodilation (i.e. sympathetic block) when combined with mepivacaine for stellate ganglionic blockade (Kimura et al 2001;Tezuka et al 2004). Clonidine's mechanism of analgesic action in this setting remains controversial with at least one clinical study suggesting that the effects are mediated centrally and not locally at the level of the nerve axon (Mannion et al 2005).…”

Section: Discussionmentioning

confidence: 99%

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The effects of medetomidine on radial nerve blockade with mepivacaine in dogs

Lamont

Lemke

2008

Veterinary Anaesthesia and Analgesia

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“…sympathetic block) when combined with mepivacaine for stellate ganglionic blockade (Kimura et al. 2001; Tezuka et al. 2004).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The effects of medetomidine on radial nerve blockade with mepivacaine in dogs

Lamont

Lemke

2008

Veterinary Anaesthesia and Analgesia

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“…Because of their local and central analgesic characteristics, alpha-2 receptor agonists like clonidine have been employed as local anesthetic adjuncts for peripheral or central neuraxial blocks [ 3 ]. Dexmedetomidine is an alpha-2 agonist with eight times more affinity for alpha-2 receptors than clonidine.…”

Section: Discussionmentioning

confidence: 99%

“…Sympathetic blocks (stellate ganglion block and lumbar plexus block) have been beneficial in patients with CRPS [ 2 ]. Alpha-2 receptor agonists such as clonidine and dexmedetomidine have been clinically used for central and peripheral nerve blocks because of their local and central analgesic effects [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Dexmedetomidine as an Adjunct in a Fluoroscopically Guided Stellate Ganglion Block for Complex Regional Pain Syndrome

Sheikh¹,

Baig²

2023

Cureus

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Complex regional pain syndrome (CRPS) is a chronic pain disorder characterized by pain that is disproportionate to the inciting event. Autonomic and inflammatory responses predominate, and treatment plans that explicitly target these responses reduce symptoms for longer periods of time, are typically better tolerated, and have more favorable outcomes. Our patient was a young male who presented with a four-month history of a road traffic accident (RTA) that resulted in a fractured left distal radius and scaphoid. His main complaint was pain and discomfort, even after surgical forearm stabilization, as well as hyperesthesia, restricted range of motion, and new-onset tremors. The patient was provisionally diagnosed with complex regional pain syndrome (CRPS) and booked for a fluoroscopically guided stellate ganglion block when the oral medication regime provided minimal relief. A stellate ganglion block was administered using a combination of ropivacaine, methylprednisolone, and dexmedetomidine under fluoroscopic guidance. During our routine outpatient follow-ups, our patient's pain score on the visual analog scale (VAS) fell to zero, the burning, vasomotor, and temperature abnormalities subsided, and he gradually regained the use of his left forearm and hand. The etiology of complex regional pain syndrome is multifaceted. Early identification and therapy typically halt the progression. Long-term outcomes are improved by treatment strategies that target inflammatory and autonomic responses. Dexmedetomidine has a mild anti-nociceptive action when used as an adjuvant in peripheral nerve blocks and ganglion blocks, blocking pain transmission in Aδ and C fibers. We feel that by combining dexmedetomidine and a stellate ganglion block, we could provide immediate and long-term relief to our patient. More research is needed to monitor and analyze the efficacy of dexmedetomidine as a treatment for chronic pain syndromes such as CRPS.

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Tramadol sparing effect of dexmedetomidine as an adjuvant with lignocaine in preoperative stellate ganglion block for postoperative pain relief following upper limb surgeries

Thapa

Dhiman

Ahuja

et al. 2017

British Journal of Pain

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Addition of dexmedetomidine prolongs duration of vasodilation induced by sympathetic block with mepivacaine in dogs

Abstract: The addition of dexmedetomidine prolongs the duration of vasodilation induced by stellate ganglion block with mepivacaine used for sympathetic block in dogs.

Cited by 3 publications

References 26 publications

The effects of medetomidine on radial nerve blockade with mepivacaine in dogs

The effects of medetomidine on radial nerve blockade with mepivacaine in dogs

Dexmedetomidine as an Adjunct in a Fluoroscopically Guided Stellate Ganglion Block for Complex Regional Pain Syndrome

Tramadol sparing effect of dexmedetomidine as an adjuvant with lignocaine in preoperative stellate ganglion block for postoperative pain relief following upper limb surgeries

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