Addition of cohesion promotors to calcium phosphate cements

Khaϊroun, I.; Driessens, F. C. M.; Boltong, M. G.; Planell, Josep A.; Wenz, R.

doi:10.1016/s0142-9612(98)00202-6

Cited by 168 publications

(101 citation statements)

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“…Generally, the setting time is long P/L ratio is low. 19) This experimental result was in agreement with those of the previous report. The compressive strength of the IP6/¢-TCP(3000)-3h cement specimens was higher than that of the IP6/¢-TCP(0)-3h cement, suggesting that the ability of IP6 to form chelate bonding enhances the compressive strength of the cement specimens.…”

Section: Materials Properties Of the Cpc Pastessupporting

confidence: 93%

Evaluation of resistance to fragmentation of injectable calcium-phosphate cement paste using X-ray microcomputed tomography

Nagata

Fujioka

Konishi

et al. 2017

J. Ceram. Soc. Japan

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Property of resistance to fragmentation of injectable calcium-phosphate cement (CPC) pastes was evaluated. CPC pastes are widely used as bone fillers due to their biocompatibility and osteoconductivity. However, the potential for fractures due to the formation of voids and cracks in the CPC, called "fragmentation," reduces the biomechanical strength of CPCs. To develop new CPCs that do not exhibit fragmentation, a method for assessing the presence or absence of fragmentation is required. For in vitro evaluation of the fragmentation resistance, the internal structure of cement specimens allowed to stand in pure water or blood was observed using X-ray micro-computed tomography (X-ray¯-CT) method. In the case of cement specimens derived from commercially-available ¢-tricalcium phosphate powder ball milled and surface modified in 3,000 ppm inositol phosphate solution, no cracks or voids in the internal structure were observed in samples allowed to set in either pure water or blood. For in vivo verification of the fragmentation resistance, the same CPC pastes were implanted into pig thigh muscle and tibiae for 4 and 24 weeks, respectively. The implanted CPC specimens formed a lump without internal voids or cracks. These data showed that the CPC pastes with the fragmentation resistance both in vitro and in vivo and are thus unlikely to generate fractures. Furthermore, the evaluation method using X-ray¯-CT could enables rapid and simple verification of the fragmentation resistance of the injectable CPC pastes. To our knowledge, this is the first report of the use of this method to evaluate resistance to fragmentation of CPC pastes. Furthermore, because of its simplicity and ease of use, the X-ray¯-CT method shows promise as a gold standard.

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Section: Materials Properties Of the Cpc Pastessupporting

confidence: 93%

Evaluation of resistance to fragmentation of injectable calcium-phosphate cement paste using X-ray microcomputed tomography

Nagata

Fujioka

Konishi

et al. 2017

J. Ceram. Soc. Japan

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“…These authors concluded that the second method was not adequate. Khairoun et al (1999) took over the first method proposed by Fernandez et al (1994), i.e., performed a visual inspection of the cement surface after placing the cement in early contact with a Ringer solution. The socalled cohesion time was defined as the minimum time required to obtain a stable cement paste in solution.…”

Section: Methodsmentioning

confidence: 99%

“…In other words, the method had to be quantitative and applicable to non-setting pastes. Unfortunately, none of the methods published in the literature fulfilled both criteria (Andrianjatovo and Lemaître, 1995;Cherng et al, 1997;Fernandez et al, 1994;Ishikawa et al, 1995Ishikawa et al, , 1997Khairoun et al, 1999). Therefore, a new testing method was designed that allowed a continuous and quantitative assessment of the paste cohesion.…”

Section: Methodsmentioning

confidence: 99%

“…The ability of a hydraulic paste to harden in an aqueous environment without releasing loose particles has been termed "cohesion". So far, it is known that cohesion is improved with the addition of a polysaccharide hydrogel (Andrianjatovo and Lemaître, 1995;Cherng et al, 1997;Ishikawa et al, 1995Ishikawa et al, , 1997 or a decrease of the liquid-to-solid ratio (Khairoun et al, 1999). However, there is presently no understanding for these effects.…”

Section: Introductionmentioning

confidence: 99%

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Theoretical and experimental approach to test the cohesion of calcium phosphate pastes

Bohner

Doebelin²,

Baroud³

2006

eCM

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Recent studies have revealed that the ability of a calcium phosphate cement paste to harden in a physiological environment without desintegrating into small particles might be a key property to ensure a safe and reliable clinical use of calcium phosphate cements. However, this property called cohesion is not well understood and has not been studied extensively. The goal of the present study was to better understand which factors affect the cohesion of a calcium phosphate paste using the combination of a theoretical and experimental approach. In the theoretical approach, factors expected to influence the paste cohesion such as Van der Waals forces, electrostatic and steric interactions, as well as osmotic effects were listed and discussed. In the experimental approach, a new method to measure the cohesion of a non-setting calcium phosphate paste was presented and used to assess the effects of various factors on this property. The new method allowed a continuous measurement of cohesion and gave reproducible results. The experimental results confirmed the theoretical predictions: an increase of the liquid-to-powder ratio of the paste and of the powder particle size, as well as the addition of citrate ions and in limited cases dissolved xanthan polymer chains reduced the paste cohesion.

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“…For example, an appropriate cohesion was achieved when no disintegration of the paste was observed in the fluid [153,308]. This can be accomplished by keeping a high viscosity for self-setting pastes [22] or using cohesion promoters (e.g., 1% aqueous solution of sodium alginate [200,310,311], as well as other chemicals [200,[312][313][314] (Table 3) are not injectable and blood must be kept away from the implanting site until setting [4,5]. A poor cohesion has been associated to a poor biocompatibility that might lead to inflammatory reactions [309].…”

Section: Rheological Propertiesmentioning

confidence: 99%

Self-Setting Calcium Orthophosphate Formulations

Dorozhkin¹

2012

Calcium Orthophosphates

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Abstract:In early 1980s, researchers discovered self-setting calcium orthophosphate cements, which are bioactive and biodegradable grafting bioceramics in the form of a powder and a liquid. After mixing, both phases form pastes, which set and harden forming either a non-stoichiometric calcium deficient hydroxyapatite or brushite. Since both of them are remarkably biocompartible, bioresorbable and osteoconductive, self-setting calcium orthophosphate formulations appear to be promising bioceramics for bone grafting. Furthermore, such formulations possess excellent molding capabilities, easy manipulation and nearly perfect adaptation to the complex shapes of bone defects, followed by gradual bioresorption and new bone formation. In addition, reinforced formulations have been introduced, which might be described as calcium orthophosphate concretes. The discovery of self-setting properties opened up a new era in the medical application of calcium orthophosphates and many commercial trademarks have been introduced as a result. Currently such formulations are widely used as synthetic bone grafts, with several advantages, such as pourability and injectability. Moreover, their low-temperature setting reactions and intrinsic porosity allow loading by drugs, biomolecules and even cells for tissue engineering purposes. In this review, an insight into the self-setting calcium orthophosphate formulations, as excellent bioceramics suitable for both dental and bone grafting applications, has been provided.

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Addition of cohesion promotors to calcium phosphate cements

Cited by 168 publications

References 0 publications

Evaluation of resistance to fragmentation of injectable calcium-phosphate cement paste using X-ray microcomputed tomography

Evaluation of resistance to fragmentation of injectable calcium-phosphate cement paste using X-ray microcomputed tomography

Theoretical and experimental approach to test the cohesion of calcium phosphate pastes

Self-Setting Calcium Orthophosphate Formulations

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