Addisonian Pernicious Anaemia without Gastric Atrophy in a Young Man

Pernicious Anaemia, Myxoedema, and Hypogammaglobulinaemia--A Family Study

“…There appears to be a particularly high family incidence in those rare cases where the condition occurs in children and young adults (Reisner, Wolff, McKay, and Doyle, 1951;Mollin, Baker, and Doniach, 1955 ;Leikin, 1960;Lambert, Prankerd, and Smellie, 1961).…”

“…For years following Castle's work, the cause of pernicious anaemia had been thought to be impaired secretion of intrinsic factor due to gastric atrophy, although this view had been questioned by some authorities (Askey, 1944 ;Murphy, 1948). Several cases have now been reported of proved pernicious anaemia in children and young adults where gastric biopsy revealed normal gastric mucosa (Mollin et al, 1955Leikin, 1960Lambert et al, 1961). It becomes apparent either that gastric atrophy is not essential to the development of pernicious anaemia or that pernicious anaemia in children and that in adults are different diseases.…”

Isolation and Characterization of an Abnormal Human Intrinsic Factor

“…A number of children have been reported in the literature (2,3,(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) …”

Vitamin B12 deficiency in chronic gastritis

“…First there is a rare juvenile group in whom a genetic abnormality causes depleted production of intrinsic factor and resulting megaloblastic anaemia in the absence of gastric atrophy (Reisner, Wolff, McKay, and Doyle, 1951;Mollin, Baker, and Doniach, 1955;Harris-Jones, Swan, and Tudhope, 1957;Clement, Nichol, and Welch, 1961).…”