Addison's Disease in Childhood

D’Albora, James B.

doi:10.1001/archpedi.1966.02090050140014

Cited by 10 publications

(5 citation statements)

References 11 publications

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“…In the present case no pigmentation was detected on the skin or mucous membranes, but this is not an unusual finding in children. Hypoglycemia is a very frequent symptom (> 90%) in children and is attributed to the low levels of circulating cortisol which is an insulinantagonist hypoglycemia [3,5,12].…”

Section: Discussionmentioning

confidence: 99%

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Sudden death due to auto-immune Addison's disease in a 12-year-old girl

Sabri

Smith

Busuttil

1997

International Journal of Legal Medicine

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A 12-year-old female suffering from adrenocortical insufficiency showed symptoms similar to a gastro-enteritis, and severe electrolytic and acid/base disturbances which progressed into cerebral oedema and death. Autopsy findings included depletion of the adrenal cortex, with enlargement and eosinophilia of surviving cells. In ante-mortem blood, anti-adrenal auto-antibodies were found and elevated levels of ACTH and cortisol with a low level of aldosterone.

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Section: Discussionmentioning

confidence: 99%

“…The prognosis of Addison's disease depends on early recognition and prompt treatment and with adequate correct therapy and parental support patients will have a normal life and normal life span [3,5].…”

Section: Discussionmentioning

confidence: 99%

Sudden death due to auto-immune Addison's disease in a 12-year-old girl

Sabri

Smith

Busuttil

1997

International Journal of Legal Medicine

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“…A recent report cited only 106 well-documented cases under 15 years of age (D'Albora and Martin, 1966). The usual aetiology in the past was tuberculosis, but idiopathic atrophy is now thought to be the most frequent cause.…”

Section: Discussionmentioning

confidence: 99%

Familial congenital adrenal hypoplasia.

Uttley¹

1968

Archives of Disease in Childhood

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“…Six patients with mild Addison's disease showed near-normal increments in urinary steroids after ACTH infusion (7). A child with Addison's disease responded with a 3-fold increase in urinary 17-hydroxycorticosteroids after 3 days on ACTH gel (5). Adults with the primary adrenocortical failure of Schmidt's (2 1) and Chiari-Frommel's (25) syndromes showed prompt increases in urinary plasma steroids in ACTH tests.…”

Section: /14mentioning

confidence: 99%