Addison'S Disease And Pregnancy

Albert, Eva; Dalaker, Knut; Jorde, Rolf; Berge, Lillian Nordbø

doi:10.3109/00016348909009909

Cited by 47 publications

(30 citation statements)

References 5 publications

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“…Twothirds of the daily dose is given when the patient awakens, with the remainder given in the afternoon as in the normal circadian rhythm of cortisol. Our patients did not need an increase in their doses of hydrocortisone as described previously in other case reports (1). Hydrocortisone is also the method of choice during the acute treatment of adrenal crisis.…”

Section: Discussionsupporting

confidence: 58%

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Pregnancies associated with primary adrenal insufficiency

Fux-Otta

Mereshian

Iraci

et al. 2008

Fertility and Sterility

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Section: Discussionsupporting

confidence: 58%

“…One of the leading reports was done in Norway during a 12-year span. It describes five women with six neonates, with an estimated incidence of AI in pregnancy of 1 per 3000 births (1). We studied three patients between 1992 and 2004, which represents a prevalence of 1:10,000 births.…”

mentioning

confidence: 99%

Pregnancies associated with primary adrenal insufficiency

Fux-Otta

Mereshian

Iraci

et al. 2008

Fertility and Sterility

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“…intrauterine deaths, suboptimal birthweight and reduced foetal growth (58,59,60). However, if provided adequate hormonal replacement, the majority of women can expect uneventful pregnancies of normal duration and without maternal or foetal compromise (61,62,63,64). The first population-based epidemiological study on pregnancy outcomes in PAI was recently published, confirming that most pregnancies in women with PAI are uneventful (57).…”

Section: Parity and Pregnancy Outcomementioning

confidence: 91%

MANAGEMENT OF ENDOCRINE DISEASE: Epidemiology, quality of life and complications of primary adrenal insufficiency: a review

Bensing

Hulting

Husebye

et al. 2016

European Journal of Endocrinology

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In this article, we review published studies covering epidemiology, natural course and mortality in primary adrenal insufficiency (PAI) or Addison's disease. Autoimmune PAI is a rare disease with a prevalence of 100-220 per million inhabitants. It occurs as part of an autoimmune polyendocrine syndrome in more than half of the cases. The patients experience impaired quality of life, reduced parity and increased risk of preterm delivery. Following a conventional glucocorticoid replacement regimen leads to a reduction in bone mineral density and an increase in the prevalence of fractures. Registry studies indicate increased mortality, especially evident in patients diagnosed with PAI at a young age and in patients with the rare disease autoimmune polyendocrine syndrome type-1. Most notably, unnecessary deaths still occur because of adrenal crises. All these data imply the need to improve the therapy and care of patients with PAI.

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“…Prior to the introduction of steroid therapy, Addison's disease was associated with a high maternal mortality rate. However if it is diagnosed and treated adequately before the pregnancy, adverse effects are uncommon and there is successful maternal and foetus-neonatal outcome 24,25 .…”

Section: Resultsmentioning

confidence: 99%

Diagnosis and Management of Addison's Disease in a Nulliparous Woman followed by Successful Pregnancy Outcome in a Rural Tertiary Hospital: A Case Report

Islam¹,

Ali²,

Solayman³

et al. 2017

KYAMC j.

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Introduction: Addison's disease is a relatively rare endocrine condition requiring life-long glucocorticoid and mineralcorticoid replacement therapy. Women with Addison's disease may have a reduced parity. Addisonian crises, a rare but life-threatening event in pregnant women, may accompany stressful conditions such as labor, puerperium, infection, hyperemesis gravidarum or surgery.Case Presentation: This is a case report of previously healthy 24-year-old nulliparous woman presented with a history of fatigue, fever, diarrhoea and skin darkening. She had pale conjunctiva, low blood pressure, tachycardia, some dehydration, hyperpigmentation of palmer creases, knuckles, buccal mucosa and face. Her serum cortisol was low and rapid ACTH stimulation test with Synacthen showed a poor cortisol response. Patient was immediately managed with IV steroid and later dicharged with oral steroid. After 6 months she became pregnant and the steroid therapy was regulated to avoid adrenal crisis during pregnancy. The patient underwent to caesarean section at 38th week and gave birth to a normal baby.Conclusion: Addisonian crisis represents an endocrine emergency that requires a correct diagnosis with prompt and appropriate salt and steroid replacements to save the patient. Though Addison's disease in women is a risk factor for an adverse pregnancy outcome, it is believed that appropriately treated patients can expect to have uneventful pregnancies of normal duration and without fetal compromise.KYAMC Journal Vol. 7, No.-2, Jan 2017, Page 814-817

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Addison'S Disease And Pregnancy

Abstract: Five case reports are presented illustrating that pregnancy and Addison's disease are not incompatible, provided adequate substitution therapy is given.

Cited by 47 publications

References 5 publications

Pregnancies associated with primary adrenal insufficiency

Pregnancies associated with primary adrenal insufficiency

MANAGEMENT OF ENDOCRINE DISEASE: Epidemiology, quality of life and complications of primary adrenal insufficiency: a review

Diagnosis and Management of Addison's Disease in a Nulliparous Woman followed by Successful Pregnancy Outcome in a Rural Tertiary Hospital: A Case Report

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