Addison's disease and diabetes mellitus

Kogut, Maurice D.; Brinegar, Charles H.

doi:10.1016/s0022-3476(72)80300-7

Cited by 9 publications

(5 citation statements)

References 16 publications

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“…The normal histological appearance of the pancreas and the absence of any pancreatic auto-antibodies, and normal HbA/C (glycosylated haemoglobin) level support this contention. Autoimmune Addison's disease may occur as an isolated entity, it may also be associated with other organ-specific auto-immune diseases such as hypoparathyroidism, primary hypogonadism, pernicious anaemia, autoimmune thyroid disease, vitiligo, insulin-dependent diabetes mellitus and chronic active hepatitis [3,9,11,16,20,21,24]. These diseases are more common in adult patients and predominate in females [3,21].…”

Section: Discussionmentioning

confidence: 99%

Sudden death due to auto-immune Addison's disease in a 12-year-old girl

Sabri

Smith

Busuttil

1997

International Journal of Legal Medicine

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A 12-year-old female suffering from adrenocortical insufficiency showed symptoms similar to a gastro-enteritis, and severe electrolytic and acid/base disturbances which progressed into cerebral oedema and death. Autopsy findings included depletion of the adrenal cortex, with enlargement and eosinophilia of surviving cells. In ante-mortem blood, anti-adrenal auto-antibodies were found and elevated levels of ACTH and cortisol with a low level of aldosterone.

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Section: Discussionmentioning

confidence: 99%

Sudden death due to auto-immune Addison's disease in a 12-year-old girl

Sabri

Smith

Busuttil

1997

International Journal of Legal Medicine

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“…(J Clin Endocrinol Metab 54: 949,1982) R ECENT evidence has suggested that insulin-dependent diabetes mellitus (IDD) may be associated with autoimmunity. Indirect evidence for an autoimmune mechanism in the pathogenesis of diabetes mellitus is derived from the coexistence of this disorder with other autoimmune diseases, including pernicious anemia, autoimmune thyroid diseases, Addison's disease, hypoparathyroidism, and myasthenia gravis (1,2). The demonstration of lymphocytic infiltration of the islet cells, termed insulitis, in autopsies of patients with diabetes mellitus of recent onset has provided additional evidence for an abnormal immune mechanism (3)(4)(5)(6).…”

mentioning

confidence: 99%

Pancreatic Islet Cell and Thyroid Antibodies, and Islet Cell Function in Diabetic Patients of Mexican-American Origin*

Zeidler

Frasier

Penny

et al. 1982

The Journal of Clinical Endocrinology & Metabolism

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Two hundred and thirty-six diabetic patients of Mexican-American origin were studied for the presence of pancreatic islet cell antibodies (ICA) and thyroid microsomal antibodies (TMA). One hundred and thirty-one subjects were insulin-dependent diabetic patients (IDD; type I), and 105 were noninsulin-dependent diabetic patients (NIDD; type II). The control population consisted of 79 normal subjects with no family history of diabetes mellitus.In addition, residual B-cell function (C-peptide) and C-peptide response to the iv administration of 1 mg glucagon were studied in IDD patients positive and neagtive for ICA.The prevalence of ICA was 25.9% in IDD patients, significantly higher than the 8.5% observed in the NIDD patients and the control population (P < 0.01). In IDD patients, the prevalence of ICA was strongly dependent on the duration of the disease and was 50% during the first year after diagnosis, 20.7% 2-5 yr after diagnosis, 11.7% 11-20 yr after diagnosis, and 2.9% over 21 yr after diagnosis. The prevalence of positive TMA in IDD patients was not significantly different from that in NIDD patients (4.5% vs. 2.8%; P = NS). Basal serum C-peptide and Cpeptide response to glucagon in IDD patients were similar in patients with and without ICA. Although there was a trend toward higher levels of basal C-peptide in NIDD patients positive for ICA compared to patients negative for ICA, the difference did not reach statistical significance (1.07 ± 0.36 vs. 0.62 ± 0.19 pmol/ml, respectively; P = NS).These findings, suggesting a lower prevalence of ICA and TMA in IDD patients of Mexican-American origin compared to Caucasian IDD patient populations in Europe and the United States, may indicate ethnic differences and the possible genetic heterogeneity of IDD populations. Residual B-cell function in IDD patients did not correlate with the presence or absence of ICA. However, in NIDD patients, C-peptide levels were found to be significantly increased in patients with or without ICA. This latter finding may be explained in part by the known hyperinsulinemic state in NIDD patients and may not be related directly to ICA. (J Clin Endocrinol Metab 54: 949, 1982)

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“…Simultaneous onset of diabetes mellitus and Addison's disease is rare; however, it can cause diagnostic and therapeutic problems ( I ) . The previously reported children have been mostly males (2). Our case is of interest because of the early age of onset of both conditions.…”

Section: Discussionmentioning

confidence: 75%

Diabetes Mellitus and Addison's Disease in an Adolescent Female

Matsaniotis

Tzortzatou‐Stathopoulou

Thomaidis

et al. 1981

Acta Paediatrica

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Diabetes mellitus and Addison's disease in an adolescent female. Acta Paediatr Scand, 70: 949, 1981.-This short report describes a 16-year-old female who presented with Addison's disease 6 years after diabetes mellitus had been diagnosed. The possibility of both conditions being present should be borne in mind whenever an unexplained reduction of insulin requirements is noted, especially if this is accompanied by cutaneous pigmentation. The metabolic interrelationships of the two conditions are briefly discussed.

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Addison's disease and diabetes mellitus

Cited by 9 publications

References 16 publications

Sudden death due to auto-immune Addison's disease in a 12-year-old girl

Sudden death due to auto-immune Addison's disease in a 12-year-old girl

Pancreatic Islet Cell and Thyroid Antibodies, and Islet Cell Function in Diabetic Patients of Mexican-American Origin*

Diabetes Mellitus and Addison's Disease in an Adolescent Female

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