Addison's Disease and Addisonian Anæmia

Irvine, W. J.; Stewart, Alexandra G. A.; Scarth, Laura

doi:10.1016/s0140-6736(67)92202-7

Cited by 4 publications

(9 citation statements)

References 4 publications

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“…Similar to previous studies, females prevailed among AAD patients in the current cohort, and, intriguingly, their age at disease onset was significantly higher than in males [10][11][12][13][14]. The latter observation seems to be a consistent finding in AAD, however, no plausible explanation has been proposed to date.…”

Section: Discussionsupporting

confidence: 87%

“…Moreover, due to lack of a gold standard, variable diagnostic criteria of ChAG and pernicious anaemia might have been applied in different studies. These are the probable reasons why several reports provide various data concerning the prevalence of both diseases among AAD patients [10][11][12]17]. In a series of 263 Italian AAD subjects, ChAG was observed in 11% of patients with APS2 and 8% of subjects with APS4 [2].…”

Section: Discussionmentioning

confidence: 99%

“…Former investigations of the coexistence of AAD and gastric autoimmunity mainly relied on complement fixation or immunofluorescence-based tests [10,12,17]. Moreover, due to lack of a gold standard, variable diagnostic criteria of ChAG and pernicious anaemia might have been applied in different studies.…”

Section: Discussionmentioning

confidence: 99%

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Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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Autoimmune Addison's disease (AAD) is the main reason of primary adrenal failure. More than a half of patients display additional autoimmune conditions, which represent a considerable clinical concern. This study aimed to investigate the prevalence of concomitant autoimmune disorders in 85 Polish AAD patients (61 females, 24 males). Mean age at AAD onset was 34.6 ± 12.6 years, significantly earlier in males (P < 0.001). Sixty-nine patients presented positive serum antibodies to 21-hydroxylase and shorter AAD duration than those with negative results (P = 0.027). Seventy-three subjects suffered from coexisting autoimmune disorders. Serum autoantibodies against thyreoperoxidase, thyroglobulin, TSH receptor, glutamic acid decarboxylase, insulin, tyrosine phosphatase-like protein IA2, parietal cell H(+)/K(+)-ATPase, intrinsic factor and tissue transglutaminase were detectable in 71.8, 41.2, 4.7, 21.0, 4.9, 2.5, 49.4, 12.0 and 3.5% of patients, respectively. Antinuclear antibodies were found in 12.5%. Thyroid autoimmunity was most common (46 subjects with lymphocytic thyroiditis, 19 with Graves' disease), followed by atrophic gastritis (29.4%), pernicious anaemia (11.8%), hypergonadotropic hypogonadism (8.2%), vitiligo (8.2%), type 1 diabetes (7.1%), celiac disease (3.5%) and alopecia (2.4%). Gender differences were observed only for thyroid autoimmunity. Current study confirms particular tendency of AAD patients to develop other autoimmune disorders. Active search for concomitant conditions is warranted to prevent serious complications.

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Section: Discussionsupporting

confidence: 87%

Section: Discussionmentioning

confidence: 99%

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Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Fichna

Gryczyńska

et al. 2010

Endocr

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“…Primary adrenocortical insufficiency may result from a variety of disease processes involving the adrenal cortex, such as an autoimmune reaction or tuberculosis (Irvine et al, 1967). It may also be due to a genetic enzyme defect, as in congenital adrenal hyperplasia, or follow the administration of drugs like metyrapone, which selectively inhibit adrenal enzymes necessary for cortisol synthesis.…”

Section: Introductionmentioning

confidence: 99%

Immunoreactive Corticotrophin Levels in Adrenocortical Insufficiency

Gm¹,

Cullen²,

Irvine³

et al. 1971

BMJ

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“…The observation that 34 % of patients reported to have only idiopathic adrenal insufficiency have antibodies to gastric parietal cells, parathyroid tissue and/or thyroid tissue (Irvine et al 1967), should prompt a comprehensive antibody screen and close monitoring of clinical progress, thus ensuring the early detection of disease in these preclinical states.…”

Section: Discussionmentioning

confidence: 99%

Carcinoid Heart Disease

1974

Proceedings of the Royal Society of Medicine

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Addison's Disease and Addisonian Anæmia

Cited by 4 publications

References 4 publications

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Screening for associated autoimmune disorders in Polish patients with Addison’s disease

Immunoreactive Corticotrophin Levels in Adrenocortical Insufficiency

Carcinoid Heart Disease

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