Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates – a randomized trial

Shahin, Ahmed Y.; Mohammed, Safwat A.

doi:10.3109/09513590.2014.895983

Cited by 28 publications

(67 citation statements)

References 23 publications

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“…There were 33 RCTs comprising a total of 4349 women with WHO group II anovulation, undergoing 7210 treatment cycles. Of the 33 included studies, participants were women with PCOS (without CC resistance) in 25 studies, women with CC‐resistant PCOS in five studies, women with WHO group II anovulation (with or without PCOS) in two studies and women with WHO group II anovulation (without PCOS) in one study. The characteristics of these 33 included studies are listed in Table .…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta‐analysis

Gadalla

Huang

Wang

et al. 2017

Ultrasound in Obstet & Gyne

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Section: Resultsmentioning

confidence: 99%

“…Pregnancy rate was reported in all RCTs except two; it was reported as clinical pregnancy rate except in four studies in which it was reported as a positive pregnancy test. Ovulation rate per cycle was reported in all RCTs except for four.…”

Section: Resultsmentioning

confidence: 99%

Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta‐analysis

Gadalla

Huang

Wang

et al. 2017

Ultrasound in Obstet & Gyne

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“…Rooibos increased the thickness of the endometrium without inflammation, while the myometrium was unchanged. In this way, this plant increased fertility in mice 29 . Herba menthae haplocalycis) 6 g, which has been studied on 30 women with tubular infertility with GnRHa / FSH / hCG therapy.…”

Section: Resultsmentioning

confidence: 98%

“…In general, phytoestrogens do not appear to have strong phytoestrogenic properties, and even their application does not show adverse and antiestrogenic effects in cases where the endometrial thickness is normal 29 .…”

Section: Erzhi Pilland Siwu Decoctionmentioning

confidence: 99%

Untitled

2018

IJPSR

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Endometrial thickness is one of the determinant factors in fertility success. This study was carried out to determine the effects of plants on increasing endometrial thickness and ultimately increasing fertility preservation. Key terms of "endometrium thickness" or "endometrial thickness" or "endometrial lining thickness" in combination with the words "Medicinal plant", "Herb" and "Phyto" were searched on the ISI, PubMed and Scopus databases. Then, the abstracts of the articles, as well as information obtained from other sources about medicinal plants and their derivatives from which their effects directly on endometrial thickness and pregnancy were studied, were selected. Besides, only clinical trials and laboratory studies between 2007 and 2017 were included. The results from this study showed that plants such as Cimicifuga racemosa and Aspalathus lineararis and plant derivatives such as Klimadynon and Icariin and plant formulations such as Xiaoyao powder, Erzhi pill and Siwu decoction can increase fertility in humans or animals by increasing endometrial thickness. Medicinal plants and their derivatives affect the thickness of the endometrium, mainly due to having phytoestrogen and can help maintain the fetus in the uterus and increase fertility preservation. The phytoestrogens available in plants are bound to ER-α receptors and mimics the function of estrogen. However, the effective dose, administration time, endogenous estrogen status and type of herbal prescription or derivatives are of important factors that should be considered in herbal therapy.

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“…PE plus CC group had significantly higher clinical pregnancies per cycle (33/192 (17.2%) versus 71/204 (34.8%), p < 0.01), compared to the CC only group. They concluded that adding CR to clomiphene-induction cycles with timed intercourse in polycystic ovarian syndrome improves cycle outcomes and pregnancy rates [10] .…”

Section: Discussionmentioning

confidence: 99%

Phytoestrogens as an alternative to estradiol in reversing the antiestrogenic effect of clomid on endometrium in ovulation induction in cases of PCO

Maged

Deeb

2015

Uterus Ovary

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Objective:To study the effect of phytoestrogens as an alternative to estradiol in reversing the antiestrogenic effect of clomid on endometrium in ovulation induction in cases of PCOS. Methods: Prospective study conducted on 150 women with PCOS were randomly divided using automated web based randomization system into 3 groups: group I included 50 women received CC only50 mg orally every 8 hours started from cycle day 3 for 5 days, group II included 50 women received estradiol from cycle day 7 to day 11 in addition to CC and group III included 50 women received phytoestrogen (20mg of cimifuga racemosa from day 1to12) in addition to CC. Results: There was a statistically significant difference between group I and the other two groups regarding occurrence of ovulation (82 vs.100 and 100 % respectively) A statistically significant difference was found between the three study groups regarding endometrial thickness (5.5±1.07 vs. 9.37 ±1.75 and 10.1±1.87 respectively). Also a significant difference was found between group I and the other two groups regarding pregnancy rate (18 vs.34 and 26 % respectively). Conclusion: Adding phytoestrogens to CC as an alternative to estradiol in PCOS women have increased the count of dominant follicles and improved endometrial thickness and pattern with improvement of both ovulation and pregnancy rates.

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Adding the phytoestrogen Cimicifugae Racemosae to clomiphene induction cycles with timed intercourse in polycystic ovary syndrome improves cycle outcomes and pregnancy rates – a randomized trial

Abstract: Adding CR to clomiphene-induction cycles with timed intercourse in polycystic ovarian syndrome improves cycle outcomes and pregnancy rates.

Cited by 28 publications

References 23 publications

Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta‐analysis

Effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: systematic review and meta‐analysis

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Phytoestrogens as an alternative to estradiol in reversing the antiestrogenic effect of clomid on endometrium in ovulation induction in cases of PCO

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