Adding methylphenidate to prism-adaptation improves outcome in neglect patients. A randomized clinical trial

Luauté, Jacques; Villeneuve, Laurent; Roux, Adeline; Nash, Stuart; Bar, Jean-Yves; Chabanat, E.; Cotton, François; Ciancia, S.; Sancho, P.O.; Hovantruc, P.; Quelard, F.; Sarraf, Thierry; Cojan, Yann; Hadj-Bouziane, Fadila; Farnè, Alessandro; Janoly‐Dumenil, Audrey; Boisson, Dominique; Jacquin-Courtois, Sophie; Rode, Gilles; Rossetti, Yves

doi:10.1016/j.cortex.2018.03.028

Cited by 16 publications

(7 citation statements)

References 37 publications

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“…This study was conducted in the RITAPRISM cohort (Luauté et al 2018). Briefly, patients included in the RITAPRISM cohort fulfilled the following criteria: age above 18 and less than 80 years-old, right-handed, ischemic or haemorrhagic right stroke (>1 month, <18 months after the incident); as previously described in Luauté et al (2018) spatial neglect was confirmed by classical paper and pencil tests (line bisection, line cancellation, balloon-test, copy of a scene, drawing a daisy from memory).…”

Section: Methodsmentioning

confidence: 99%

“…The RITAPRISM study was a multicentre, double-blind and placebo-controlled study (Luauté et al 2018). All patients provided written informed consent.…”

Section: Methodsmentioning

confidence: 99%

“…A previous study demonstrated a long-term functional improvement after MP combined with PA in a group of patients suffering from left spatial neglect after a right stroke (Luauté et al 2018). However, there was heterogeneity in the clinical improvement after prismatic adaptation in patients within the “MP+PA” group with the identification of responders and non-responders.…”

Section: Introductionmentioning

confidence: 92%

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Co-administration of prism adaptation and methylphenidate needs striatal integrity to alleviate spatial neglect

Beaudoin-Gobert

Benistant

Lanversin

et al. 2023

Preprint

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ContextA previous study demonstrated a long-term functional improvement of spatial neglect after methylphenidate combined with prismatic adaptation in a group of patients suffering from left spatial neglect after a right stroke (RITAPRISM study).Objectivewe hypothesized that the functional improvement after MP combined with PA depends on striatal integrity in responders patients.MethodsWe conducted an MRI study in “MP+PA” program to identify lesional pattern in responders and non-responders patients in the RITAPRISM cohort. Using anatomical segmentation on morphological MRI, we compared lesional pattern in the striatum between responders and non-responders patients.ResultsThe beneficial effect of MP+PA co-administration should require striatal integrity in neglect patients. More specifically, our results suggest that the short-term effect is mediated by the ventral striatum whereas the long-term effect is mediated by the posterior putamen.ConclusionBenefical effet of MP+PA could rely on reinforcement processes at early stage of the MP+PA program and visuospatial substrates at long-term.

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Section: Methodsmentioning

confidence: 99%

“…The RITAPRISM study was a multicentre, double-blind and placebo-controlled study (Luauté et al 2018). All patients provided written informed consent.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 92%

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Co-administration of prism adaptation and methylphenidate needs striatal integrity to alleviate spatial neglect

Beaudoin-Gobert

Benistant

Lanversin

et al. 2023

Preprint

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“…[58][59][60] Furthermore, we designed our study to include a large cohort of students, randomly assigned to an intervention or control group, as in clinical trials. 61,62…”

Section: Introductionmentioning

confidence: 99%

Does nonviolent communication education improve empathy in French medical students?

et al. 2021

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Objectives To evaluate the impact of nonviolent communication (NVC) training on five aspects of medical students' empathy skills using implicit and explicit measures. Methods 312 third-year French medical students were randomly allocated to an intervention group (n = 123) or a control group (n = 189). The intervention group received 2.5 days of NVC training. For each group, empathy-related skills were measured implicitly using three cognitive tests (Visuo-Spatial Perspective Taking, Privileged Knowledge, Empathy for Pain evaluation) and explicitly using two self-rating questionnaires (Jefferson Scale of Physician Empathy, Empathy Quotient). Both groups completed tests and questionnaires before (pre-test) and three months after training (post-test). Responses were collected via online software, and data were analyzed using paired linear mixed models and Bayes Factors. Results We found a significant increase in the Jefferson Scale of Physician Empathy (JSPE) score between pre- and post-tests in the intervention group compared to the control group (linear mixed models: 0.95 points [0.17, 1.73], t (158) = 2.39, p < 0.05), and an expected gender effect whereby females had higher JSPE scores (1.57 points [0.72, 2.42], t (262) = -3.62, p < 0.001). There was no interaction between these two factors. Conclusions Our results show that brief training in nonviolent communication improves subjective empathy three months after training. These results are promising for the long-term effectiveness of NVC training on medical students' empathy and call for the introduction of NVC training in medical school. Further studies should investigate whether longer training will produce larger and longer-lasting benefits.

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“…Some studies have applied combined or sequential training in order to boost the efficacy of each method and to improve the overall outcome [12][13][14][15], but very few studies have compared the effectiveness of different treatments. Two bottom-up treatments have been considered here, namely prism adaptation (PA) and optokinetic stimulation (OKS).…”

Section: Introductionmentioning

confidence: 99%

Prism Adaptation and Optokinetic Stimulation Comparison in the Rehabilitation of Unilateral Spatial Neglect

2021

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Prism adaptation (PA) is one of the most effective treatments for the rehabilitation of unilateral spatial neglect. Optokinetic stimulation (OKS) has also been demonstrated to be effective in ameliorating symptoms of neglect. The aim of this study is to compare the effectiveness of these two methods in a group of neglect patients using a crossover design. A group of 13 post-acute brain-damaged patients with unilateral spatial neglect, who had never been rehabilitated, were treated using PA and OKS. Each treatment was applied for 10 sessions, twice a day, to all patients with both treatments in crossed order (i.e., PA followed by OKS or vice versa). Neuropsychological assessments were performed: before the first (T1), at the end of the first/beginning of the second (T2) and at the end of the second training sessions (T3), and two weeks after the end of treatment (T4). Both procedures produced a significant improvement in clinical tests at T2, independent of the type of training. The results suggest that either PA or OKS induces a significant amelioration of neglect in right brain-damaged patients, mainly in the first block of treatment. Since no differences between treatments were found, they could be applied in clinical practice, according to the requirements of the individual patient.

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Adding methylphenidate to prism-adaptation improves outcome in neglect patients. A randomized clinical trial

Cited by 16 publications

References 37 publications

Co-administration of prism adaptation and methylphenidate needs striatal integrity to alleviate spatial neglect

Co-administration of prism adaptation and methylphenidate needs striatal integrity to alleviate spatial neglect

Does nonviolent communication education improve empathy in French medical students?

Prism Adaptation and Optokinetic Stimulation Comparison in the Rehabilitation of Unilateral Spatial Neglect

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