Adding biological markers to COPD categorisation schemes: a way towards more personalised care?

Roche, N.

doi:10.1183/13993003.00401-2016

Cited by 8 publications

(4 citation statements)

References 46 publications

(37 reference statements)

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“…Chronic obstructive pulmonary disease (COPD) is a chronic health problem with high morbidity and mortality 1,2 . The Global Initiative for Chronic Obstructive Pulmonary Disease (GOLD) defines it as a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usually caused by significant exposure to noxious particles or gases 3 It is a complex heterogenous condition that has also been described as a syndrome 4 . Its etiology is multifactorial with smoking remaining the primary cause.…”

Section: Introductionmentioning

confidence: 99%

Exhaled breath condensate: a potential tool to evaluate the relationship between inflammation and dyspnea in patients with chronic obstructive pulmonary disease

Patsiris¹,

Stelios²,

Papanikolaou³

et al. 2021

J Lung Health Dis

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Chronic obstructive pulmonary disease (COPD) is a respiratory disease with high prevalence. Many factors contribute to its development, and probably that leads to its various clinical pictures. Inflammation is the mechanism responsible for the structural alterations in the lungs. Despite its heterogeneity, there are a couple of primary symptoms characterizing it, which are chronic and productive cough and dyspnea. The understanding of dyspnea in COPD is based on theories deriving from the interaction of a network formed between the cardiorespiratory and the neuromuscular system and their receptors. Many factors contribute to its occurrence, making it complex and giving it a very subjective character for a person to perceive. Various methods are used to study COPD. Non-invasive ones seem to attract attention nowadays. One of them is the exhaled breath condensate. It is a biofluid with rich content, which can capture a picture of the pathological processes happening in the lungs. Its study has shown that some markers of inflammation and oxidative stress, such as 8-isoprostane and H2O2, are elevated and able to connect dyspnea and inflammation. Additionally, they seem to provide information of the ongoing inflammatory process in the lungs as well as a picture of the severity of the symptoms. This evidence may enhance the association of dyspnea with dysfunctional breathing. Despite these interesting findings, further research is necessary both in dyspnea and inflammation in COPD to clarify their mechanisms and connective pathways. The utility of non-invasive techniques such as the exhaled breath condensate could be of significant help, but its establishment in the medical field requires extra studies.

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Section: Introductionmentioning

confidence: 99%

Exhaled breath condensate: a potential tool to evaluate the relationship between inflammation and dyspnea in patients with chronic obstructive pulmonary disease

Patsiris¹,

Stelios²,

Papanikolaou³

et al. 2021

J Lung Health Dis

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“…COPD phenotypes is essential to provide patients with precise and personalized therapy. Most phenotypes rely on clinical and physiological parameters and biological markers may complete them, clinicians should select the tools to be used according to the aim of phenotyping such as prognosis evaluation , treatmet response or research (Roche, 2016). Some research studies have examined specific phenotype frequencies and features but limited ones are available to address the effect of these phenotypes on clinical outcome, purposing to intensify the lines of treatment available for those with the worst outcomes.…”

Section: Introductionmentioning

confidence: 99%

Clinical Outcomes of Different Phenotypes of Chronic Obstructive Pulmonary Disease

Said

Naiem

Fattah

et al. 2020

Minia Journal of Medical Research

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Introduction: Chronic obstructive pulmonary disease (COPD) is a critically important international health problem. Aim of the study: The aim of this study was to: Assess the effect of different COPD phenotypes on disease outcomes as regard disease severity, inflammatory burden, comorbidity and exacerbation. Patients and Methods: Design of work The clinical study was a prospective study included 100 patients with stable COPD who were presented as out-patients to chest clinic at Cardiothoracic Minia University hospital during the period between October 2018 to December 2019. Results: Distribution of different COPD phenotypes cases:-patients with chronic bronchitis were more than emphysema in both exacerbator and non exacerbator phenotypes.

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“…In clinical practice, however, it is important to define and manage the determinant factors of therapeutic success in COPD. There is a need to personalise treatment strategies,11 and four goals must be achieved. First, we have to assess the patient in a multidimensional way, according to the severity of the disease, its activity, future risk and impact on the patient, including their well-being.…”

mentioning

confidence: 99%

¿Es útil el concepto de control de la EPOC?: evaluación del éxito terapéutico a partir de la valoración del estado de salud en relación con la EPOC

Duarte-de-Araújo

Hespanhol

Sousa

2017

Archivos de Bronconeumología

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Adding biological markers to COPD categorisation schemes: a way towards more personalised care?

Cited by 8 publications

References 46 publications

Exhaled breath condensate: a potential tool to evaluate the relationship between inflammation and dyspnea in patients with chronic obstructive pulmonary disease

Exhaled breath condensate: a potential tool to evaluate the relationship between inflammation and dyspnea in patients with chronic obstructive pulmonary disease

Clinical Outcomes of Different Phenotypes of Chronic Obstructive Pulmonary Disease

¿Es útil el concepto de control de la EPOC?: evaluación del éxito terapéutico a partir de la valoración del estado de salud en relación con la EPOC

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