Addictive drugs modify neurogenesis, synaptogenesis and synaptic plasticity to impair memory formation through neurotransmitter imbalances and signaling dysfunction

Rezayof, Ameneh; Ghasemzadeh, Zahra; Sahafi, Oveis Hosseinzadeh

doi:10.1016/j.neuint.2023.105572

Cited by 4 publications

(2 citation statements)

References 343 publications

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“…Addictive substances are strong Pharmaceuticals 2024, 17, 615 2 of 16 rewarding stimuli. Once the reward is delayed, the abuser will have a psychological desire to take the substance, resulting in the relapse behavior [13][14][15][16]. Therefore, interrupting the reward pathway and alleviating withdrawal symptoms are the keys to successful substance abuse rehabilitation.…”

Section: Introductionmentioning

confidence: 99%

Substance Addiction Rehabilitation Drugs

Yuan,

Jiang,

Zhang

et al. 2024

Pharmaceuticals

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The relapse rate of substance abusers is high, and addiction rehabilitation adjunct drugs need to be developed urgently. There have been numerous reports on blocking the formation of substance addiction, but studies on drugs that can alleviate withdrawal symptoms are very limited. Both the dopamine transporter (DAT) hypothesis and D3 dopamine receptor (D3R) hypothesis are proposed. DAT activators reduce the extracellular dopamine level, and D3R antagonists reduce the neuron’s sensitivity to dopamine, both of which may exacerbate the withdrawal symptoms subsequently. The D3R partial agonist SK608 has biased signaling properties via the G-protein-dependent pathway but did not induce D3R desensitization and, thus, may be a promising drug for the withdrawal symptoms. Drugs for serotoninergic neurons or GABAergic neurons and anti-inflammatory drugs may have auxiliary effects to addiction treatments. Drugs that promote structural synaptic plasticity are also discussed.

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Section: Introductionmentioning

confidence: 99%

Substance Addiction Rehabilitation Drugs

Yuan,

Jiang,

Zhang

et al. 2024

Pharmaceuticals

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“…The underlying molecular mechanisms primarily involve the brain reward system, associated with dopamine release [2][3][4]. Acute drug exposure disrupts neurotransmitter signaling, localization, metabolism, and synthesis, resulting in neuroadaptive changes that contribute to the development of addiction [5,6]. Prolonged drug exposure induces neuroplastic changes, altering the structure and function of neurons and influencing synaptic connections, thus impacting reward neuronal circuitry and resulting in long-term behavioral changes [7,8].…”

Section: Introductionmentioning

confidence: 99%

Breaking the Chains: Advances in Substance Addiction Research through Single-Cell Sequencing, Epigenetics, and Epitranscriptomic

Filošević Vujnović,

Stanković Matić,

Saftić Martinović

et al. 2024

Future Pharmacology

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Addiction is a complex brain disease influenced by genetic, environmental, and neurological factors. Psychostimulants, cocaine, and methamphetamine influence different cell types in different brain regions, with a focus on the neurons responsible for rewarding effects in the nucleus accumbens (NAc) and ventral tegmental area (VTA). Known markers for psychostimulant-induced neuronal plasticity in combination with droplet-based high-throughput single-cell sequencing divided the heterogeneity of cell populations in NAc and VTA into clusters, where all cells of the same type do not respond equally to exposure to psychostimulants. To explain psychostimulant-induced neuronal plasticity as changes in the amplitude and phase shifts of gene expression, we focused on epigenetic mechanisms of DNA and chromatin modifications, as well as DNA accessibility. We also comment on epitranscriptomics as a novel approach in the study of messenger RNA posttranslational modification, which regulates translation and potentially localized transcription in synapses in order to address the molecular chains that connect addiction from changes in gene expression to synaptic and, finally, neuronal plasticity.

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